Anti-rheumatic activity ofAnanas comosusfruit peel extract in a complete Freund’s adjuvant rat model

Abstract

Context: Rheumatoid arthritis is a chronic, autoimmune and systemic inflammatory disease, which targets synovial joints leading to joint destruction mediated in part by migration of inflammatory cells into the synovial tissue. Objective: The present study evaluates the anti-rheumatic effect of a methanol extract of Ananas comosus (L.) Merr. (Bromeliaceae) peel in rats. Materials and methods: Anti-rheumatic activity of crude extract of peels of A. comosus in complete Freund's induced arthritis model in rats was studied at doses of 50, 100, 250 and 500 mg/kg b.w. for 21 days. Parameters such as paw size, levels of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), C-reactive proteins (CRP) and prostaglandins (PGE 2 ) were analysed. Results: Oral administration of the extract significantly reduced the swelling in the paw of rats (EC 50 65.1 ± 2.95 mg/kg b.w.) with a maximal inhibition of 77.01 ± 10.53% on 21st day at 500 mg/kg b.w. The extract also significantly reduced the levels of SOD, CAT and GPx in liver (EC 50 26.84 ± 16.37, 68.37 ± 19.22, 106.54 ± 34.81 mg/kg b.w., respectively), kidney (EC 50 261.75 ± 81.5, 176.38 ± 8.08, 14.32 ± 6.64, mg/kg b.w., respectively) and spleen (EC 50 152.14 ± 39.57, 83.97 ± 14.6, 47.1 ± 10.45 mg/kg b.w., respectively); and CRP (EC 50 36.37 ± 12.4 mg/kg b.w.) and PGE 2 (EC 50 191.06 ± 71.54 mg/kg b.w.) in tissue homogenate and serum, respectively, at 500 mg/kg b.w. as compared to arthritic control group. Discussion and conclusion: These results suggest that A. comosus fruit peel extract exerts anti-rheumatic activity.ARTICLE HISTORY

Statistical Optimization and Characterization of Acoustically Extracted Ananas Comosus Peel Powder With Enhanced Antioxidant Capacity

“…The model equation was used to estimate the best experimental conditions, and to describe the interaction between the assessed parameters (Eqn. 1): [1] where Y is the response; j and k are the linear and quadratic coefficients, respectively, Xi and Xj are the uncoded independent parameters, l represents the number of studied and optimized variables in the experiment, β0 is a constant coefficient; βj, βjj and βjk are the interaction coefficients of linear, quadratic and second−order terms, respectively; and finally, ε is the error.…”

“…Ananas comosus (L.) Merr, otherwise known 'nanas' in Southeast Asia or pineapple in English, is a plant from the Bromeliaceae family that is native to the Central and South Americas [1] and grows well in tropical and subtropical regions, such as Thailand, Malaysia, Philippines, India, China, Hawaii, South Africa and Kenya. Its yellow, sweet−flavored flesh contains an appreciably high content of carotenoid, which causes the pulp to have the same hue as the peels.…”

“…These compounds are known for their beneficial properties on human health such as anti−inflammatory and anti−allergenic, as well as cardio and neuroprotective effects. Likewise, the polyphenolic−rich PP extracts are useful as value−added products in certain manufacturing industries, such as pharmaceutical and cosmeceutical industries [1,6]. Hence, exploring the chemical wealth of this biomass while establishing various avenues to efficiently recover these compounds from PP biomass merits scientific consideration.…”

Investigation of antioxidant, antibacterial, antidiabetic, and cytotoxicity potential of silver nanoparticles synthesized using the outer peel extract of Ananas comosus (L.)

“…These polyphenolic compounds exhibit their antioxidant potential [19]. Methanolic extract of AC fruit peel also shows anti-rheumatic activity [20]. It has been reported that AC peel extract has antioxidative and antibacterial potential, which can be useful in food applications [9, 21, 22].…”

Phytochemicals in the Treatment of Arthritis: Current Knowledge

“…Bromelain decreased swelling and pain by inhibition of cyclooxigenase-2 (COX-2) and prostaglandin E2 (PGE2) expression in rheumatoid arthritis. It ameliorated the inflammation by protection of cartilage from damage in rheumatoid arthritis at a dose 100 and 500 mg/kg [49]. In an experiment, it showed a significant effect on knee treatment suffering in osteoarthritis at a dose 10 mg/kg [50].…”