2021
DOI: 10.1515/jpem-2021-0289
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Anti-SARS-CoV-2 antibodies in new-onset type 1 diabetes in children during pandemic in Belgium

Abstract: Objectives Questions are emerging concerning the long-term consequences of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic, as a possible increase in type 1 diabetes. This study aims to describe the prevalence of anti-SARS-CoV-2 antibodies in children developing type 1 diabetes during this pandemic in Belgium. Methods This observational study included children and adolescents (under 16 years) admitte… Show more

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Cited by 17 publications
(11 citation statements)
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“…Our results indicate that the incidence of childhood autoimmune T1DM increased during the third wave of the COVID-19 epidemic with more than half (52%) of the tested children having a previous coronavirus infection as proven by a positive anti-SARS-CoV-2 serological test. Our findings are in contrast with the results of two studies demonstrating no increase of SARS-CoV-2 seropositivity among newly diagnosed diabetic children [6,7]. However, these studies were conducted during the first year of the pandemic, while we examined our children during the third wave in Hungary.…”
contrasting
confidence: 99%
“…Our results indicate that the incidence of childhood autoimmune T1DM increased during the third wave of the COVID-19 epidemic with more than half (52%) of the tested children having a previous coronavirus infection as proven by a positive anti-SARS-CoV-2 serological test. Our findings are in contrast with the results of two studies demonstrating no increase of SARS-CoV-2 seropositivity among newly diagnosed diabetic children [6,7]. However, these studies were conducted during the first year of the pandemic, while we examined our children during the third wave in Hungary.…”
contrasting
confidence: 99%
“…Data from the literature regarding SARS-CoV-2-precipitated T1DM in children and adolescents are contradictory. 7 , 19 , 20 In our series, of the 40 patients with onset during the COVID-19 pandemic and who underwent some kind of diagnostic test for SARS-CoV-2 infection, up to 12.5% of cases were in some way associated with SARS-CoV-2 infection. In December 2020, the overall prevalence in Spain among 16-year-old adolescents was around 5%, according to the ENECOVID seroprevalence study 21 almost half the figure obtained from our sample.…”
Section: Discussionmentioning
confidence: 70%
“…Higher incidence of diabetic ketoacidosis in the pediatric cohort compared to pre-pandemic data could be attributed to delayed care seeking and less accessibility to healthcare [4] . Lack of significantly higher anti-SARS-CoV-2 antibodies in children with incident T1DM during pandemic have argued against the temporal association between COVID-19 and T1DM [19] , [20] . Moreover, recent reports indicate that infection of human pancreatic islets by COVID-19 remains largely non-cytopathic and unlikely to precipitate new-onset diabetes [21] .…”
Section: Discussionmentioning
confidence: 99%