Anti-TMV activity flavones from the leaves of Yunnan local air cured tobacco

Ming-ming, Miao; Li, Lan; Shen, Qinpeng; Liu, Chunbo; Li, Yin-Ke; Zhang, Tao; Zhang, Fengmei; He, Ping; Wang, Kun-Miao; Zhu, Ruizhi; Yongkuan, Chen; Yang, Guangyu

doi:10.1016/j.fitote.2015.04.014

Cited by 31 publications

(6 citation statements)

References 13 publications

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“…The other groups of flavonols detected in this study were myricetin 3- O -galactoside (RT = 16.784 min with m / z 479.0818) and myricetin 3- O -rhamnoside (RT = 29.834 min with m / z 463.0863) in negative mode. Apigenin derivatives have also been found in air-cured tobacco in a previous study . In tobacco SN-1, SN-2, and SP-28, compound 29 was identified as apigenin 6- C -glucoside, which had the precursor ion [M – H] − at m / z 431.0968.…”

Section: Resultsmentioning

confidence: 99%

Screening of Polyphenols in Tobacco (Nicotiana tabacum) and Determination of Their Antioxidant Activity in Different Tobacco Varieties

Zou

Saeed

et al. 2021

ACS Omega

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Tobacco (Nicotiana tabacum) is an herbaceous plant originating from South America and processed into cigarettes for consumption. Polyphenols are considered vital components of tobacco in view of their contribution to antioxidant properties. This study aimed to determine the phenolic compounds in different tobacco varieties by applying cold extraction with methanol and distilled water. The extracts were screened for phenolic compound diversity and distribution as well as their antioxidant potential in different tobacco varieties. The results showed that the methanolic extract of tobacco SP-28 exhibited the highest value in the total phenolic content (24.82 ± 0.07 mg GAE/gd.w.) and total flavonoid content (4.42 ± 0.01 mg QE/gd.w.), while the water extract of tobacco SN-2 exhibited the highest value in the total condensed tannin (1.12 ± 0.03 mg CE/gd.w.). The radical scavenging capacities of tobacco SP-28 were relatively high in DPPH (18.20 ± 0.01 mg AAE/gd.w.) and FRAP (3.02 ± 0.10 mg AAE/gd.w.), whereas the ABTS value was the highest in tobacco SN-2 (37.25 ± 0.03 mg AAE/gd.w.), and the total antioxidant capacity was the highest in tobacco SN-1 (7.43 ± 0.18 mg AAE/gd.w.). LC-ESI-QTOF-MS/MS identified a total of 49 phenolic compounds, including phenolic acids (14), flavonoids (30), and other polyphenols (5) in four different tobacco varieties. Tobacco SP-28 showed the highest number of phenolic compounds, especially enriched in flavones. Our study highlights the antioxidant potential of tobacco extracts and reveals the phenolic distribution among different tobacco varieties that could support tobacco utilization in different pharmaceutical industries.

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Section: Resultsmentioning

confidence: 99%

Screening of Polyphenols in Tobacco (Nicotiana tabacum) and Determination of Their Antioxidant Activity in Different Tobacco Varieties

Zou

Saeed

et al. 2021

ACS Omega

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“…86 and 111 exhibited strong anti-TMV activity with inhibition rates of 35.3% and 39.6%, respectively, which are in the same range as measured for the positive control (31.5%). The other compounds showed anti-TMV activity with inhibition rates in the range of 18.7–28.4% …”

Section: Metabolite Classes: Structures and Functionsmentioning

confidence: 99%

“…The other compounds showed anti-TMV activity with inhibition rates in the range of 18.7−28.4%. 263 Six flavones, paranicflavones A, B, C (116,117,87), desmodol (118), 7,8,3′,4′-tetrahydroxyflavone (119), and melanoxetin (120), were isolated from the roots and stems of Tiandeng tobacco. Among the tested compounds, 117 with an inhibition rate of 35.8% inhibited TMV activity more efficiently than the positive control, ningnanmycin (Figure 12).…”

Section: Relationship Between General and Specialized Metabolism In P...mentioning

confidence: 99%

Ecological Roles and Biological Activities of Specialized Metabolites from the GenusNicotiana

Jassbi¹,

Zare²,

Asadollahi³

et al. 2017

Chem. Rev.

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Species of Nicotiana grow naturally in different parts of the world and have long been used both medicinally and recreationally by human societies. More recently in our history, Nicotiana tabacum has attracted interest as one of the most economically important industrial crops. Nicotiana species are frequently investigated for their bioactive natural products, and the ecological role of their specialized metabolites in responses to abiotic stress or biotic stress factors like pathogens and herbivores. The interest of tobacco companies in genetic information as well as the success of a few wild tobacco species as experimental model organisms have resulted in growing knowledge about the molecular biology and ecology of these plants and functional studies of the plant's natural products. Although a large number of reviews and books on biologically active natural products already exists, mostly from N. tabacum, we focus our attention on the ecological roles and biological activity of natural products, versus products from cured and processed material, in this Review. The studied compounds include alkaloids, aromatic compounds, flavonoids, volatiles, sesquiterpenoids, diterpenes alcohols, and sugar esters from trichomes of the plants, and recently characterized acyclic hydroxygeranyllinalool diterpene glycosides (HGL-DTGs). In this Review (1800s-2017), we describe the above-mentioned classes of natural products, emphasizing their biological activities and functions as they have been determined either in bioassay-guided purification approaches or in bioassays with plants in which the expression of specific biosynthetic genes has been genetically manipulated. Additionally, a review on the history, taxonomy, ecology, and medicinal application of different Nicotiana species growing around the globe presented in this Review may be of interest for pharmacognosists, natural products, and ecological chemists.

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“…Since it is certain that C‐alkylated flavonoids exhibit potential anti‐TMV activity, 20,46,47 compounds 1–12 were evaluated for their anti‐TMV activity. The anti‐TMV activity was tested by the half‐leaf method, 25,26 using ningnanmycin (with inhibition rate of 34.6%) as a positive control.…”

Section: Resultsmentioning

confidence: 99%

C‐Alkylated flavonoids from the whole plants of Desmodium caudatum and their anti‐TMV activity

Xiong

et al. 2023

Pest Management Science

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BackgroundNatural products are important sources of biopesticides to control plant virus, and flavonoids are identified as promising anti‐tobacco mosaic virus (TMV) agents. Since Desmodium caudatum is a rich source of flavonoids, this study focuses on the discovery of the new anti‐TMV active flavonoids from D. caudatum and their possible mode of action.ResultsThree new (compounds 1–3) and nine known (compounds 4–12) C‐alkylated flavonoids were isolated from D. caudatum. To the best of our knowledge, the framework of 1–3 was reported in natural products for the first time. In addition, 1–3, 5, and 6 showed notable anti‐TMV activity with inhibition rates in the range of 35.8–64.3% at a concentration of 50 μg/mL, and these rates are higher than that of positive control (with inhibition rates of 34.6% ± 2.8). In addition, the structure–activity relationship study revealed that the (pyrrol‐2‐yl)methyl moiety on flavone can significantly increases the activity. This result is helpful to find new anti‐TMV inhibitors.ConclusionC‐Alkylated flavonoids showed potent activities against TMV with multiple modes of actions. The increase of defense‐related enzyme activities, up‐regulate the expression of defense related genes, down‐regulate the expression of Hsp70 protein by inhibiting the related Hsp genes that are involved in tobacco resistance to TMV. By the actions mentioned earlier, the infection of TMV was influenced, thereby achieving the effects of control of TMV. The successful isolation of the earlier‐mentioned flavonoids provide the new source of biopesticides to TMV proliferation, and also contribute to the utilization of D. caudatum. © 2023 Society of Chemical Industry.

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Anti-TMV activity flavones from the leaves of Yunnan local air cured tobacco

Cited by 31 publications

References 13 publications

Screening of Polyphenols in Tobacco (Nicotiana tabacum) and Determination of Their Antioxidant Activity in Different Tobacco Varieties

Screening of Polyphenols in Tobacco (Nicotiana tabacum) and Determination of Their Antioxidant Activity in Different Tobacco Varieties

Ecological Roles and Biological Activities of Specialized Metabolites from the GenusNicotiana

C‐Alkylated flavonoids from the whole plants of Desmodium caudatum and their anti‐TMV activity

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