Anti-Tumour and Anti-Oxidative Potential of Diosgenin against 7, 12-Dimethylbenz(a)anthracene Induced Experimental Oral Carcinogenesis

Rajalingam, Kasinathan; Govindasamy, S.; Vijayaanand, Mariadoss Arokia; Kalaimathi, J.; Suresh, K.

doi:10.1007/s12253-011-9460-1

Cited by 15 publications

(4 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The direct relationships between lipid peroxidation (LPx) and antioxidant have been well reported in literature,[30] our results are in agreement with other observations. Exposures of DMBA significantly increased in LPx and decreased in antioxidant status were reported.…”

Section: Discussionsupporting

confidence: 93%

Biochemical profiling and chemopreventive activity of phloretin on 7,12-dimethylbenz (A) anthracene induced oral carcinogenesis in male golden syrian hamsters

Anand¹,

Suresh²

2014

Toxicol Int

View full text Add to dashboard Cite

Objectives:The present study was designed to examine the chemopreventive effects of phloretin against 7, 12-dimethylbenz (a) anthracene (DMBA) induced buccal pouch carcinogenesis in male golden Syrian hamsters in order to discover resources to improve the traditional medicine.Materials and Methods:Hamsters were divided into four groups of 10 animals each. Group I was served as an untreated control. Group II hamsters were painted with 0.5% DMBA in liquid paraffin on the left buccal pouches three times a week for 14 weeks. Group III hamsters were orally administrated with phloretin at a dose of 40 mg/kg body Weight (b.wt) on days alternate to DMBA application. Group IV hamsters were orally administrated with phloretin alone and served as the drug control. The experiment was terminated at the end of fourteenth week. The experimental animal's tumors were subjected into morphological examination and subsequently screened the pathological changes and estimate the activities of bi-products of lipid peroxidation, antioxidants enzymes and phase I and II detoxification enzyme status.Results:In DMBA alone treated hamster showed increased levels of lipid peroxidation by products, leads to decreased levels of enzymatic and non-enzymatic antioxidants status, activities of phase I and II detoxification enzyme status were altered. Normalized the neoplastic changes, decreased the levels of lipid by products, retain the antioxidants and restored the phase I and II enzymes were observed in phloretin administrated animals during DMBA induced oral carcinogenesis.Conclusion:Phloretin has possible chemopreventive role in which modulating the antioxidant and detoxification enzyme status, thereby retarding DMBA induced buccal pouch carcinogenesis.

show abstract

Section: Discussionsupporting

confidence: 93%

Biochemical profiling and chemopreventive activity of phloretin on 7,12-dimethylbenz (A) anthracene induced oral carcinogenesis in male golden syrian hamsters

Anand¹,

Suresh²

2014

Toxicol Int

View full text Add to dashboard Cite

show abstract

“…Numerous studies have demonstrated the increased lipid peroxidation and declining antioxidant status in experimental oral carcinogenesis [50]. On the other hand, tumor tissue has the ability to prevent lipid peroxidation through the highly evolved protective mechanisms so that rapid cell proliferation can occur [51]. Cancer cells are known to acquire certain characteristics that benefit proliferation [52] and they tend to proliferate faster when lipid peroxidation is low.…”

Section: Discussionmentioning

confidence: 99%

Polydatin Encapsulated Poly [Lactic-co-glycolic acid] Nanoformulation Counteract the 7,12-Dimethylbenz[a] Anthracene Mediated Experimental Carcinogenesis through the Inhibition of Cell Proliferation

et al. 2019

View full text Add to dashboard Cite

In the present study, the authors have attempted to fabricate Polydatin encapsulated Poly [lactic-co-glycolic acid] (POL-PLGA-NPs) to counteract 7,12-dimethyl benzyl anthracene (DMBA) promoted buccal pouch carcinogenesis in experimental animals. The bio-formulated POL-PLGA-NPs were characterized by dynamic light scattering (DLS), Fourier transform infrared (FTIR) spectroscopy, X-ray powder diffraction (XRD) pattern analysis, and transmission electron microscope (TEM). In addition, the nano-chemopreventive potential of POL-PLGA-NPs was assessed by scrutinizing the neoplastic incidence and analyzing the status of lipid peroxidation, antioxidants, phase I, phase II detoxification status, and histopathological changes and in DMBA-treated animals. In golden Syrian hamsters, oral squamous cell carcinoma (OSCC) was generated by painting with 0.5% DMBA in liquid paraffin three times a week for 14 weeks. After 100% tumor formation was observed, high tumor volume, tumor burden, and altered levels of biochemical status were observed in the DMBA-painted hamsters. Intra-gastric administration of varying concentration of POL-PLGA-NPs (7.5, 15, and 30 mg/kg b.wt) to DMBA-treated hamsters assumedly prevents oncological incidences and restores the status of the biochemical markers. It also significantly enhances the apoptotic associated and inhibits the cancer cell proliferative markers expression (p53, Bax, Bcl-2, cleaved caspase 3, cyclin-D1). The present study reveals that POL-PLGA-NPs is a penitential candidate for nano-chemopreventive, anti-lipid peroxidative, and antioxidant potential, and also has a modulating effect on the phase I and Phase II detoxification system, which is associated with reduced cell proliferation and induced apoptosis in experimental oral carcinogenesis.

show abstract

“…(22) Diosgenin decreased the oral tumor incidence signifi cantly in male Syrian golden hamster cheek pouch at the dose of 80 mg/kg by oral administration every other day for 16 weeks. (23) Esophageal Cancer Esophageal cancer is a common malignant tumor of digestive system. Diosgenin mainly have an obvious role on esophageal cancer cells Eca109.…”

Section: Antitumor Effects Of Diosgenin Digestive System Tumors Oral ...mentioning

confidence: 99%

Anticancer Activity of Diosgenin and Its Molecular Mechanism

Ren

Wang

Zhang

et al. 2023

Chin. J. Integr. Med.

View full text Add to dashboard Cite

Diosgenin, a steroidal sapogenin, obtained from Trigonella foenum-graecum, Dioscorea , and Rhizoma polgonati , has shown high potential and interest in the treatment of various cancers such as oral squamous cell carcinoma, laryngeal cancer, esophageal cancer, liver cancer, gastric cancer, lung cancer, cervical cancer, prostate cancer, glioma, and leukemia. This article aims to provide an overview of the in vivo, in vitro , and clinical studies reporting the diosgenin’s anticancer effects. Preclinical studies have shown promising effects of diosgenin on inhibiting tumor cell proliferation and growth, promoting apoptosis, inducing differentiation and autophagy, inhibiting tumor cell metastasis and invasion, blocking cell cycle, regulating immunity and improving gut microbiome. Clinical investigations have revealed clinical dosage and safety property of diosgenin. Furthermore, in order to improve the biological activity and bioavailability of diosgenin, this review focuses on the development of diosgenin nano drug carriers, combined drugs and the diosgenin derivatives. However, further designed trials are needed to unravel the diosgenin’s deficiencies in clinical application. Electronic Supplementary Material Supplementary material is available in the online version of this article at 10.1007/s11655-023-3693-1.

show abstract

Anti-Tumour and Anti-Oxidative Potential of Diosgenin against 7, 12-Dimethylbenz(a)anthracene Induced Experimental Oral Carcinogenesis

Cited by 15 publications

References 41 publications

Biochemical profiling and chemopreventive activity of phloretin on 7,12-dimethylbenz (A) anthracene induced oral carcinogenesis in male golden syrian hamsters

Biochemical profiling and chemopreventive activity of phloretin on 7,12-dimethylbenz (A) anthracene induced oral carcinogenesis in male golden syrian hamsters

Polydatin Encapsulated Poly [Lactic-co-glycolic acid] Nanoformulation Counteract the 7,12-Dimethylbenz[a] Anthracene Mediated Experimental Carcinogenesis through the Inhibition of Cell Proliferation

Anticancer Activity of Diosgenin and Its Molecular Mechanism

Contact Info

Product

Resources

About