Antiangiogenic activity of Andrographis paniculata extract and andrographolide

Sheeja, K; Guruvayoorappan, Chandrasekharan; Kuttan, Girija

doi:10.1016/j.intimp.2006.10.002

Cited by 130 publications

(73 citation statements)

References 34 publications

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“…We found that a natural product, andrographolide, significantly suppressed v-Src-induced transformation. Andrographolide is a lactone diterpenoid isolated from the Chinese herb Andrographis paniculata and has been previously shown to exhibit a wide spectrum of pharmacological activities, such as anti-apoptosis, anti-inflammation, anti-angiogenesis, and anti-cancer activity (22)(23)(24)(25)(26). The anti-cancer effect of andrographolide was demonstrated by showing its growthinhibitory activity on various cancer cell lines in vitro and its tumor-suppressive activity in animal models (27).…”

mentioning

confidence: 99%

Suppression of v-Src Transformation by Andrographolide via Degradation of the v-Src Protein and Attenuation of the Erk Signaling Pathway

Liang¹,

Chao

Kuo

et al. 2008

Journal of Biological Chemistry

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mentioning

confidence: 99%

Suppression of v-Src Transformation by Andrographolide via Degradation of the v-Src Protein and Attenuation of the Erk Signaling Pathway

Liang¹,

Chao

Kuo

et al. 2008

Journal of Biological Chemistry

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“…In a model of induction of angiogenesis in C57BL/6 mice, andrographolide reduced the serum levels of cytokines of IL-1β, IL-6, TNFα and GM-CSF, the angiogenic factor VEGF and the NO production. Additionally, it is observable an increase of the levels of antiangiogenic factors TIMP-1 and IL-2 [12]. Andrographolide also suppresses breast tumor growth, which correlates with the inhibition of the pro-angiogenic molecules OPN and VEGF, in the NOD/SCID mice model [70].…”

Section: In Vivo Studiesmentioning

confidence: 93%

“…Preclinical properties include anti-retroviral [6,7], antiproliferative and pro-apoptotic [8,9], anti-diabetic [10,11], anti-angiogenic [12], anti-thrombotic [13], anti-urothelial [14], anti-leishmaniasis [15], hepatoprotective [16,17], protective activity against alcohol-induced hepatic and renal toxicity [18], and cardioprotective [19] and anti-inflammatory [20][21][22][23][24][25] …”

Section: Andrographis Paniculata and Labdane Diterpenoidsmentioning

confidence: 99%

Andrographolide a New Potential Drug for the Long Term Treatment of Rheumatoid Arthritis Disease

Hidalgo¹,

Hancke²,

Bertoglio³

et al. 2013

Innovative Rheumatology

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“…Among the herbal drugs identified, the andrographolide is a promising new anticancer agent that could significantly induced HLJ1 expression and suppress tumour growth and invasion in NSCLC [90] . Andrographolide, a diterpenoid lactone isolated from the Chinese herbal medicine Andrographis paniculata, is known for its wide pharmacological activities, such as its anti-inflammatory, antiangiogenesis, pro-apoptosis and anticancer activities [91] . Moreover, Andrographis paniculata has long been perceived as safe in traditional Chinese medicine as well as in the traditional medicine in Thailand and India.…”

Section: Hlj1 As a Molecular Target In Anticancer Therapiesmentioning

confidence: 99%

Tumour suppressor HLJ1: A potential diagnostic, preventive and therapeutic target in non-small cell lung cancer

Tsai¹

2014

WJCO

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Lung cancer is the leading cause of cancer-related mortality throughout the world. Non-small cell lung cancer (NSCLC) accounts for 85% of all diagnosed lung cancers. Despite considerable progress in the diagnosis and treatment of the disease, the overall 5-year survival rate of NSCLC patients remains lower than 15%. The most common causes of death in lung cancer patients are treatment failure and metastasis. Therefore, developing novel strategies that target both tumour growth and metastasis is an important and urgent mission for the next generation of anticancer therapy research. Heat shock proteins (HSPs), which are involved in the fundamental defence mechanism for maintaining cellular viability, are markedly activated during environmental or pathogenic stress. HSPs facilitate rapid cell division, metastasis, and the evasion of apoptosis in cancer development. These proteins are essential players in the development of cancer and are prime therapeutic targets. In this review, we focus on the current understanding of the molecular mechanisms responsible for HLJ1's role in lung cancer carcinogenesis and progression. HLJ1, a member of the human HSP 40 family, has been characterised as a tumour suppressor. Research studies have also reported that HLJ1 shows promising dual anticancer effects, inhibiting both tumour growth and metastasis in NSCLC. The accumulated evidence suggests that HLJ1 is a potential biomarker and treatment target for NSCLC.© 2014 Baishideng Publishing Group Inc. All rights reserved.Key words: Non-small cell lung cancer; Metastasis; HLJ1; Anticancer; Biomarker Core tip: HLJ1, a member of the human heat shock proteins 40 family, has been characterised as a tumour suppressor. Research studies have reported that HLJ1 shows promising dual anticancer effects, inhibiting both tumour growth and metastasis in non-small cell lung cancer (NSCLC). The accumulated evidence suggests that HLJ1 is a potential biomarker and treatment target for NSCLC. We propose a hypothetical model for the roles of HLJ1 stimulator in suppressing lung cancer tumourigenesis. Investigating the integrated and coordinated molecular mechanisms of HLJ1 may shed new light on the treatment of lung cancer. The development of drug targeting HLJ1 may be an effective approach for lung cancer therapy.Tsai MF, Wang CC, Chen JJW. Tumour suppressor HLJ1: A potential diagnostic, preventive and therapeutic target in nonsmall cell lung cancer.

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Antiangiogenic activity of Andrographis paniculata extract and andrographolide

Cited by 130 publications

References 34 publications

Suppression of v-Src Transformation by Andrographolide via Degradation of the v-Src Protein and Attenuation of the Erk Signaling Pathway

Suppression of v-Src Transformation by Andrographolide via Degradation of the v-Src Protein and Attenuation of the Erk Signaling Pathway

Andrographolide a New Potential Drug for the Long Term Treatment of Rheumatoid Arthritis Disease

Tumour suppressor HLJ1: A potential diagnostic, preventive and therapeutic target in non-small cell lung cancer

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