Antibacterial activities and mechanisms of fluorinated graphene and guanidine-modified graphene

Wang, Xu; Lü, Peng; Li, Yuan; Xiao, Huining; Li, Xiangyang

doi:10.1039/c5ra28030c

Cited by 25 publications

(32 citation statements)

References 51 publications

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“…The antibacterial activity of GO had been reported in previous research 24,47,48. The bactericidal effect could be due to physical damage of bacterial cell membrane induced by sharp edges of grapheme nanosheets, leading to the leakage of bacterial intracellular contents 10,48.…”

Section: Resultsmentioning

confidence: 77%

Novel Poly(vinyl alcohol)/Chitosan/Modified Graphene Oxide Biocomposite for Wound Dressing Application

Chen

Wang

Jian

et al. 2020

Macromolecular Bioscience

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Rapid absorption of wound exudate and prevention of wound infection are prerequisites for wound dressing to accelerate wound healing. In this study, a novel kind of promising wound dressing is developed by incorporating polyhexamethylene guanidine (PHMG)‐modified graphene oxide (mGO) into the poly(vinyl alcohol)/chitosan (PVA/CS) matrix, conferring the dressing the required mechanical properties, higher water vapor transmission rate (WVTR), less swelling time, improved antibacterial activity, and more cell proliferation compared to the PVA/CS film crosslinked by genipin. In vivo experiments indicate that the PVA/CS/mGO composite film can accelerate wound healing via enhancement of the re‐epithelialization. PVA/CS/mGO composite film with 0.5 wt% mGO sheets displays the best wound healing properties, as manifested by the 50% higher antibacterial rate compared to GO and the wound healing rate of the mouse using this dressing is about 41% faster than the control group and 31% faster than the pure PVA/CS dressing. The underlying mechanism of the accelerated wound healing properties may be a result of the improved antibacterial ability to eradicate pathogenic bacteria on the wound area and maintain an appropriate moist aseptic wound healing environment to accelerate re‐epithelialization. These findings suggest that this novel composite PVA/CS/mGO film may have promising applications in wound dressing.

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Section: Resultsmentioning

confidence: 77%

Novel Poly(vinyl alcohol)/Chitosan/Modified Graphene Oxide Biocomposite for Wound Dressing Application

Chen

Wang

Jian

et al. 2020

Macromolecular Bioscience

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“…Consequently, GMs have also been used as nonmetal bactericide carriers to produce GM‐metal‐free nanohybrids. Antibiotics, polymers, quaternary ammonium/phosphonium salts, and halogens have been combined with GMs by noncovalent adsorption or chemical conjugation. Abdelhamid et al.…”

Section: Antimicrobial Activity Of Gmsmentioning

confidence: 99%

“…Consequently,G Ms have also been used as nonmetal bactericide carriers to produce GM-metal-free nanohybrids. Antibiotics, [108,109] polymers, [110][111][112][113][114][115][116][117][118] quaternary ammonium/phosphonium salts, [119][120][121] and halogens [122] have been combined with GMs by noncovalent adsorption or chemical conjugation.A bdelhamid et al provedt hat water-soluble antibiotic gramicidin (GD) can be adsorbed by GO through physical interactions and the antibacterial activity of the resultant GOGD is enhanced because of an increased local concentration of GD. [108] Compared with antibiotics, polymers usually cannot efficiently inhibit the growth of microorganisms;h owever,w ith their structure-mediated properties, polymers can enhancet he antimicrobial performance of GMs through different mechanisms.…”

Section: Gm Derivatives and Nanohybrids For Antimicrobial Applicationsmentioning

confidence: 99%

Two‐Dimensional Materials for Antimicrobial Applications: Graphene Materials and Beyond

Sun

2018

Chemistry An Asian Journal

123

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Since the "birth" of graphene in 2004, two-dimensional (2D) materials have attracted unprecedented research interest from scientists and have stimulated numerous applications in various fields, such as electronic/optical devices, energy storage, catalysis, sensors, and biomedicine. In this review, we summarize recent advances in the antimicrobial applications of 2D materials, such as graphene materials (GMs), layered double hydroxides (LDHs), transition-metal dichalcogenides (TMDs), graphitic carbon nitride (g-C N ), MXenes, black phosphorus (BP), and their derivatives. This review also correlates the unique physicochemical properties of 2D materials with their antimicrobial activities. Finally, some current challenges and future perspectives in this field are also presented.

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“…Different antibacterial organic compounds and polymers were used to functionalize graphene-family materials in order to enhance the antibacterial activity of the resulting composites. Based on this strategy, CS, ramizol, benzalkonium bromide (BKB) and polyhexamethylene guanidine hydrochloride (PHGC) were all applied to obtain novel antibacterial agents with remarkable antibacterial activity [ 14 , 20 , 38 , 39 , 40 ]. Compared with low molecular organic compounds, antibacterial polymers typically show prolonged lifetimes, reduced residual toxicity and enhanced antibacterial activity.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Characterization, and Bactericidal Evaluation of Chitosan/Guanidine Functionalized Graphene Oxide Composites

Gao

Sun

et al. 2016

Molecules

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In response to the wide spread of microbial contamination induced by bacterial pathogens, the development of novel materials with excellent antibacterial activity is of great interest. In this study, novel antibacterial chitosan (CS) and polyhexamethylene guanidine hydrochloride (PHGC) dual-polymer-functionalized graphene oxide (GO) (GO-CS-PHGC) composites were designed and easily fabricated. The as-prepared materials were characterized by Fourier transform infrared (FTIR), X-ray photoelectron spectrometer (XPS), field emission scanning electron microscopy (FE-SEM), transmission electron microscope (TEM), thermogravimetric analysis (TGA) and Raman spectroscopy. Their antibacterial capability towards bacterial strains was also studied by incubating both Gram-negative bacteria and Gram-positive bacteria in their presence. More significantly, the synergistic antibacterial action of the three components was assayed, and the findings implied that the as-prepared GO-CS-PHGC shows enhanced antibacterial activity when compared to its single components (GO, CS, PHGC or CS-PHGC) and the mixture of individual components. Not only Gram-negative bacteria but also Gram-positive bacteria are greatly inhibited by GO-CS-PHGC composites. The minimum inhibitory concentration (MIC) value of GO-CS-PHGC against E. coli was 32 μg/mL. With the powerful antibacterial activity as well as its low cost and facile preparation, GO-CS-PHGC has potential applications as a novel antibacterial agent in a wide range of biomedical uses.

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Antibacterial activities and mechanisms of fluorinated graphene and guanidine-modified graphene

Abstract: The antibacterial properties and mechanism of three types of graphene derivatives, graphene oxide (GO), fluorinated graphene (FG), and guanidine-modified graphene (PHGH-G), were comparatively studied.

Cited by 25 publications

References 51 publications

Novel Poly(vinyl alcohol)/Chitosan/Modified Graphene Oxide Biocomposite for Wound Dressing Application

Novel Poly(vinyl alcohol)/Chitosan/Modified Graphene Oxide Biocomposite for Wound Dressing Application

Two‐Dimensional Materials for Antimicrobial Applications: Graphene Materials and Beyond

Synthesis, Characterization, and Bactericidal Evaluation of Chitosan/Guanidine Functionalized Graphene Oxide Composites

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