Antibacterial activity of a sulfated galactan extracted from the marine alga Chaetomorpha aerea against Staphylococcus aureus

Abstract

The in vitro antimicrobial activity of the marine green algae Chaetomorpha aerea was investigated against gram-positive bacteria, gram-negative bacteria, and a fungus. The water-soluble extract of algae was composed of a sulfated (6.3%) galactan with a molecular weight of 1.160 × 10 6 Da and a global composition close to commercial polysaccharides, such as dextran sulfate or fucoidan. The polysaccharide was composed of 18% arabinose, 24% glucose, and 58% galactose. The re-suspended extracts (methanol, water) exhibited selective antibacterial activities against 3 gram-positive bacteria including Staphylococcus aureus (ATCC 25923). Minimum inhibitory concentration and minimum bactericidal concentration tests showed that the sulfated galactan could be a bactericidal agent for this strain (40 mg/mL). The results of this study confirmed the potential use of the green algae Chaetomorpha aerea as a source of antibacterial compounds.

Antibacterial effect of fucoidan from Sargassum wightii against the chosen human bacterial pathogens

“…Similarly, Pierre et al, (2011) also reported the antimicrobial effect sulfated galactan from Chaetomorpha aerea against the human bacterial pathogens such as Staphylococcus aureus, Salmonella enteretidis, P. aeruginosa, Enterococcus faecalis, Bacillus subtilis, Micrococcus luteus and Candida glabnata. It was suggested that the molecular mechanism of fucoidan on antibacterial activity is required to be further studied.…”

Synergistic Effect between Fucoidan and Antibiotics against Clinic Methicillin-Resistant <i>Staphylococcus aureus</i>

“…longissima, L. japonica, Ecklonia cava, and Eisenia bicyclis have been evaluated for their bioactivities and attributed that to the high concentration of polysaccharides in these species which are known to have antimicrobial properties [14] [16] [34]. The more susceptibility of Gram-positive bac- teria to sulfated polysaccharides was due to the differences in their cell wall structure and their composition [35]- [37].…”

Antioxidant properties of some filamentous green algae (Chaetomorpha Genus)

“…The biological properties of sulfated arabinogalactans extracted from the green algae such Chaetomorpha have been investigated. For instance, Pierre et al (2011) extracted and characterized an extracellular polysaccharide (a sulfated xyloarabinogalactan) from C. aerea with antibacterial activity against Staphylococcus aureus. Previous studies have found marked changes in the chemical constituents with change of seasons and environmental conditions (Manivannan et al 2009).…”