Antibacterial activity of gold nanoparticles and their toxicity assessment

Umamaheswari, K; Baskar, R; Chandru, K; Rajendiran, Nagappan; Chandirasekar, Shanmugam

doi:10.1186/1471-2334-14-s3-p64

Cited by 21 publications

(11 citation statements)

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“…Upon exposure to resonating laser emission line, the kinetic energy of gold nanoparticles increases resulting in local heating of the exposed target which is the gold nanoparticles treated bacteria in the present experiment. The generated photothermal effect can be employed for rapid and efficient bacterial cell destruction [22] , [23] , [24] , [25] . Laser enhancement depends on the exposure time.…”

Section: Discussionmentioning

confidence: 99%

“…The suggested mechanism for antibacterial activity of the gold nanoparticles is attributed to generation of Reactive Oxygen Species (ROS) that causes increase of the oxidative stress of microbial cells and release of intracellular lactate dehydrogenase enzyme into extracellular medium in form of vacuole formation as an indication of potent activity [27] , [28] , [29] . Such effect was enhanced and exaggerated by photothermal degeneration in combined approach, AuNPs-laser, causes quick loss of cell membrane integrity [24] .…”

Section: Discussionmentioning

confidence: 99%

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Antibacterial effect of gold nanoparticles against Corynebacterium pseudotuberculosis

Mohamed

Fouad

Elshoky³

et al. 2017

International Journal of Veterinary Science and Medicine

172

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Antibacterial effect of gold nanoparticles against Corynebacterium pseudotuberculosis

Mohamed

Fouad

Elshoky³

et al. 2017

International Journal of Veterinary Science and Medicine

172

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“…Zhang et al ( 2013 ) demonstrated that ROS generation and metal ion release significantly enhanced the antibacterial activity through uncoated AuNPs in aqueous suspension under UV irradiation (365 nm). Umamaheswari (Umamaheswari et al, 2014 ) demonstrated that the antibacterial activity of AuNPs against E. coli, Salmonella Typhi, Pseudomonas aeruginosa and Klebsiella pneumoniae were due to oxidative stress caused by increased intracellular ROS. A recent study (Zhang et al, 2013 ) evaluated AuNPs and AuNPs -laser combined therapy against C. pseudotuberculosis and suggested that the mechanism of action is related with ROS production, that causes an increase of oxidative stress of microbial cells in the form of vacuole formation as an indication of potent activity.…”

Section: Antibacterial Mechanism Of Npsmentioning

confidence: 99%

Nano-Strategies to Fight Multidrug Resistant Bacteria—“A Battle of the Titans”

McCusker²,

et al. 2018

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Infectious diseases remain one of the leading causes of morbidity and mortality worldwide. The WHO and CDC have expressed serious concern regarding the continued increase in the development of multidrug resistance among bacteria. Therefore, the antibiotic resistance crisis is one of the most pressing issues in global public health. Associated with the rise in antibiotic resistance is the lack of new antimicrobials. This has triggered initiatives worldwide to develop novel and more effective antimicrobial compounds as well as to develop novel delivery and targeting strategies. Bacteria have developed many ways by which they become resistant to antimicrobials. Among those are enzyme inactivation, decreased cell permeability, target protection, target overproduction, altered target site/enzyme, increased efflux due to over-expression of efflux pumps, among others. Other more complex phenotypes, such as biofilm formation and quorum sensing do not appear as a result of the exposure of bacteria to antibiotics although, it is known that biofilm formation can be induced by antibiotics. These phenotypes are related to tolerance to antibiotics in bacteria. Different strategies, such as the use of nanostructured materials, are being developed to overcome these and other types of resistance. Nanostructured materials can be used to convey antimicrobials, to assist in the delivery of novel drugs or ultimately, possess antimicrobial activity by themselves. Additionally, nanoparticles (e.g., metallic, organic, carbon nanotubes, etc.) may circumvent drug resistance mechanisms in bacteria and, associated with their antimicrobial potential, inhibit biofilm formation or other important processes. Other strategies, including the combined use of plant-based antimicrobials and nanoparticles to overcome toxicity issues, are also being investigated. Coupling nanoparticles and natural-based antimicrobials (or other repurposed compounds) to inhibit the activity of bacterial efflux pumps; formation of biofilms; interference of quorum sensing; and possibly plasmid curing, are just some of the strategies to combat multidrug resistant bacteria. However, the use of nanoparticles still presents a challenge to therapy and much more research is needed in order to overcome this. In this review, we will summarize the current research on nanoparticles and other nanomaterials and how these are or can be applied in the future to fight multidrug resistant bacteria.

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“…The absence of inhibition was most likely attributable to the presence of a peptidoglycan layer on the cell walls of S. aureus, which does not allow for the penetration of AgNPs. Umamaheswari et al reported MCI 80 on E. coli, S. typhi, P. aeruginosa, and K. pneumoniae, which ranged from 20 to 40 g mL −1 with a damage mechanism mediated by ROS and loss of membrane integrity [40].…”

Section: Microbiological Assaymentioning

confidence: 99%

Antibacterial Efficacy of Gold and Silver Nanoparticles Functionalized with the Ubiquicidin (29–41) Antimicrobial Peptide

Morales-Ávila

Ferro-Flores

Ocampo‐García

et al. 2017

Journal of Nanomaterials

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Recent studies have demonstrated that drug antimicrobial activity is enhanced when metallic nanoparticles are used as an inorganic support, obtaining synergic effects against microorganisms. The cationic antimicrobial peptide ubiquicidin 29–41 (UBI) has demonstrated high affinity and sensitivity towards fungal and bacterial infections. The aim of this research was to prepare and evaluate the antimicrobial efficacy of engineered multivalent nanoparticle systems based on silver or gold nanoparticles functionalized with UBI. Spectroscopy techniques demonstrated that NPs were functionalized with UBI mainly through interactions with the -NH2 groups. A significant increase in the antibacterial activity against Escherichia coli and Pseudomonas aeruginosa was obtained with the conjugate AgNP-UBI with regard to that of AgNP. No inhibition of bacterial growth was observed with AuNP and AuNP-UBI using a nanoparticle concentration of up to 182 μg mL−1. Nonetheless, silver nanoparticles conjugated to the UBI antimicrobial peptide may provide an alternative therapy for topical infections.

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Antibacterial activity of gold nanoparticles and their toxicity assessment

Cited by 21 publications

References 0 publications

Antibacterial effect of gold nanoparticles against Corynebacterium pseudotuberculosis

Antibacterial effect of gold nanoparticles against Corynebacterium pseudotuberculosis

Nano-Strategies to Fight Multidrug Resistant Bacteria—“A Battle of the Titans”

Antibacterial Efficacy of Gold and Silver Nanoparticles Functionalized with the Ubiquicidin (29–41) Antimicrobial Peptide

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