Antibacterial activity of <i>Harungana madagascariensis</i> leaf extracts

Okoli, Arinze S.; Okeke, Malachy Ifeanyi; Iroegbu, Christian Ukwuoma; Ebo, Paul

doi:10.1002/ptr.991

Cited by 58 publications

(56 citation statements)

References 7 publications

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“…11,12) Leaf extract of this plant exhibited antibacterial activity. 13) In the West province of Cameroon, the roots and bark are used by traditional healers to treat malaria. Various phenolic compounds have been isolated from this plant, among them anthraquinones, xanthones, biflavonoids, coumarins and anthrone derivatives.…”

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Anti-plasmodial Activity of Some Constituents of the Root Bark of Harungana madagascariensis LAM. (Hypericaceae)

et al. 2007

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Malaria remains the one of the most important infectious diseases in the world. It constitutes a public health problem in more than 90 countries, inhabited by about 40% of the world's population. The World Health Organisation estimates that there are 300-500 million malaria cases annually, causing 2-3 million deaths, mostly in children under five years old.1) Africa accounts for over 90% of malaria mortality. 1)Malaria also has significant economic impacts in endemic countries, costing Africa $ 12 billon in lost gross domestic product every year and consuming 40% of all public health spending.2) Most countries where Plasmodium falciparum malaria, the most severe and dangerous form of this disease, is endemic face significant parasite resistance to frequently used antimalarial drugs, in particular chloroquine and antifolates. Furthermore, resistance to artemisinins, which are the most promising new antimalarials, has been induced in rodent malarial models 3) and identified rarely in clinical isolates. If resistance to artemisinins emerges, no drug will be available to reliably offer protection against malaria in all parts in the world and the efficacy of new artemisinin-based combination therapies (ACTs), which are highly effective, but expensive, will be jeopardized. For these reasons, new effective and affordable antimalarials are badly needed. 4) In this regard research on traditional medicinal plants for their antimalarial constituents is important, to facilitate utilization of available botanical resources and to provide potentially active lead anti-plasmodial compounds, perhaps with new mechanisms of action. In Africa, the use of indigenous plants still plays an important role in the treatment of malaria. 5,6) Some anthrone derivatives from plant sources have demonstrated interesting anti-plasmodial activity. 7,8) They are also naturally occurring competive inhibitors of adenosinetriphosphate-citrate-lyase. 9) Plants of the Hypericaceae family are well known to produce bioactive anthraquinones and anthrones. They are distributed in tropical and sub-tropical regions.10) Harungana madagascariensis, a plant from this family, is used for various medicinal purposes in Africa. 11,12) Leaf extract of this plant exhibited antibacterial activity. 13) In the West province of Cameroon, the roots and bark are used by traditional healers to treat malaria. Various phenolic compounds have been isolated from this plant, among them anthraquinones, xanthones, biflavonoids, coumarins and anthrone derivatives.14-16) These compounds have demonstrated a wide range of biological activities. [16][17][18] Although some phytochemical and pharmacological studies have been carried out on H. madagascariensis, no investigation has been reported, to the best of our knowledge, on the anti-plasmodial activity of its constituents. In our continuing interest in new anti-plasmodial metabolites from plant sources, we investigated the MeOH-CH 2 Cl 2 (1 : 1) root bark extract of this plant which showed anti-plasmodial activity (IC 50 ϭ25.12 mg/m...

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Anti-plasmodial Activity of Some Constituents of the Root Bark of Harungana madagascariensis LAM. (Hypericaceae)

et al. 2007

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“…Aqueous and differrent solvent extracts of leaves of P. persica evaluated for antibacterial potential, revealed highly significant activity of methanol extract against all the test bacteria followed by ethanol extract. None of the earlier reports have demonstrated the antibacterial potential of this plant (Okoli et al, 2002;Khan et al, 2002;Ahmet et al, 2005). In the present investigation the antibacterial activity of this plant has been demonstrated for the first time.…”

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Antibacterial potential of extracts of leaves of Parrotia persica

Ahanjan¹,

Mohana²,

B.D³

et al. 2007

Afr. J. Biotechnol.

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Ethanol, methanol, chloroform, petroleum ether and aqueous extracts of leaves of Parrotia persica were evaluated for antibacterial activity. The zone of inhibition varied from 13 to 22 mm. The highest inhibittion was obtained with methanol and ethanol. Chloroform and petroleum ether extracts did not show any activity. The minimal inhibitory concentration (MIC) value of the methanol extract for the test bacteria ranged between 3.12 and 6.25 mg/ml and that of ethanol extract ranged between 6.25 and 12.5 mg/ml. The results scientifically validate the use of this plant in the traditional medicine of Iran.

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“…They also play a predominant role in oxygen and electron transport. The large amounts of Fe and Ca in H. madagascariensis stem bark shows that it could be specifically useful in the treatment of diseases and disorders like: malaria, anemia in pregnant mothers at a very low dose, as its main medicinal activities are as an anti-infective (against malaria, trichomonads, bacterial, fungi) (Okoli et al, 2002;Iwalewa et al, 2008a), anti-anemia, (Erah et al, 2003), bleeding and amenorrhea (Duke and Ayensu, 2002). For example, the red juice from the plant leaves and stem bark are reputed for arresting post-partum or post-abortal bleedings in Sierra Leone, while the unopened buds are equally reputed for treating puerperal infection in Liberia (Olagunju et al, 2000).…”

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confidence: 99%

Elemental compositions and anti-anemic property of Harungana madagascariensis stem bark

Iwalewa

Omisore

Daniyan

et al. 2009

Bangladesh J Pharmacol

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The concentrations of 15 elements and heavy metals in the stem bark of Harungana madagascariensis were determined using an energy-dispersive Xray fluorescence (EDXRF) spectrometer. The anti-anemic activity was done using the changes in hematological parameters (PCV, RBC and Hb) influenced by phenylhydrazine HCL (80 mg/kg) and malaria parasitesinduced anemia. Results show Cd, Ni, Mo, Cr and Br were in the range of 0.02 -0.9 mg/g, while Pb, Zn, Fe, Cu and Hg were in the range of 1.5-7.2 mg/g. The elements with very high concentration were Ca, K, Sr, Mn and Cl and were in the range of 10.5-774.3 mg/g. Remarkable anti-anemic activity was obtained with PCV of 40-48%, RBC count of 81-155 x 10 4 and Hb value of 57-66 g/dL after treatment; compared with 30% PCV, 67 x 10 4 RBC count and 36.5 g/dL Hb value obtained for the untreated control animals. Our results suggest that H. madagascariensis stem bark extract constituents exhibit antianemic activity. Article Info

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Antibacterial activity of Harungana madagascariensis leaf extracts

Cited by 58 publications

References 7 publications

Anti-plasmodial Activity of Some Constituents of the Root Bark of Harungana madagascariensis LAM. (Hypericaceae)

Anti-plasmodial Activity of Some Constituents of the Root Bark of Harungana madagascariensis LAM. (Hypericaceae)

Antibacterial potential of extracts of leaves of Parrotia persica

Elemental compositions and anti-anemic property of Harungana madagascariensis stem bark

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