Antibacterial activity of plant extracts from the families Fabaceae, Oleaceae, Philadelphaceae, Rosaceae and Staphyleaceae

Jantová, Soňa; Nagy, Milan; Ruzeková, L; Grančai, D

doi:10.1002/1099-1573(200012)14:8<601::aid-ptr771>3.0.co;2-b

Cited by 28 publications

(18 citation statements)

References 5 publications

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“…Leaves of L. vulgare are used for disease prevention or treatment in folk medicine in southern Europe [2], mostly because of their immunomodulatory [3], cardioprotective [4], antibacterial [5], antidiabetic effects [6], and it has also been found that different leaf and fruit extracts of this plant can scavenge OH and DPPH radicals [7]. From the traditional uses and later scientific findings, which suggested cytotoxic activity against HeLa cells [8], L. vulgare may be a potential candidate as an antiproliferative agent against cancer cell lines.…”

Section: Introductionmentioning

confidence: 99%

Antiproliferative and Proapoptotic Activities of Methanolic Extracts from Ligustrum vulgare L. as an Individual Treatment and in Combination with Palladium Complex

Ćurčić

Stanković

Mrkalić

et al. 2012

IJMS

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The aim of this study is to examine the growth inhibitory effects of methanolic leaf and fruit extracts of L. vulgare on HCT-116 cells over different time periods and their synergistic effect with a Pd(apox) complex. The antiproliferative activity of plant extracts alone or in combination with the Pd(apox) complex was determined using MTT cell viability assay, where the IC50 value was used as a parameter of cytotoxicity. Results show that antiproliferative effects of L. vulgare extracts increase with extension of exposure time, with decreasing IC50 values, except for 72 h where the IC50 values for methanolic leaf extract were lower than for the fruit extract. The Pd(apox) complex alone had a weak antiproliferative effect, but combination with L. vulgare extracts caused stronger effects with lower IC50 values than with L. vulgare extracts alone. The type of cell death was explored by fluorescence microscopy using the acridin orange/ethidium bromide method. Treatments with plant extracts caused typical apoptotic morphological changes in HCT-116 cells and co-treatments with Pd(apox) complex caused higher levels of apoptotic cells than treatment with plant extracts alone. The results indicate that L. vulgare is a considerable source of natural bioactive substances with antiproliferative activity on HCT-116 cells and which have a substantial synergistic effect with the Pd(apox) complex.

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Section: Introductionmentioning

confidence: 99%

Antiproliferative and Proapoptotic Activities of Methanolic Extracts from Ligustrum vulgare L. as an Individual Treatment and in Combination with Palladium Complex

Ćurčić

Stanković

Mrkalić

et al. 2012

IJMS

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“…Previously we have described in details the main classes of chemical components and their amounts in various plant parts [6]. The significant antibacterial (against Pseudomonas aeruginosa , Staphylococcus aureus and Enterococcus faecalis ) and cytotoxic activity of ethanol extracts from S. holocarpa and S. pinnata have been reported [7,8]. Significant antioxidant and immunomodulating activity have also been found in various polar (including water) and nonpolar Staphylea L. extracts [9,10].…”

Section: Introductionmentioning

confidence: 99%

Antiproliferative, Cytotoxic, Antioxidant Activity and Polyphenols Contents in Leaves of Four Staphylea L. Species

et al. 2009

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Staphylea has been used for long time in Traditional Chinese Medicine (TCM) and by Native Americans in a number of therapeutical indications. The present study describes in vitro antiproliferative, cytotoxic properties (MTT and LDH test) and antioxidant activities (reduction of DPPH radical and peroxynitrite radical) of Staphylea colchica Stev. (SC), S. elegans Zab. (SC), S. holocarpa Hemsl. (SH) and S. pinnata L. (SP) leave water extracts. Time- (24 and 72 h) and dose- (1-150 μg/mL) dependent effects of the above extracts were tested at the mitochondrial (MTT test) and plasma membrane level (LDH leakage) in A431 human skin carcinoma cells. Screening of these properties has shown time and dose dependent increase of harmful effects, the highest activity was observed for the SE, while the less active was the SH extract. The ED50 values for the mitochondrial and membrane damage were nearly identical for the SE and very similar for SH extract. These findings indicate simultaneous injury of both cell compartments by SE and SH extracts. The highest antioxidant potential of SE species is accompanied by the highest content of flavones/flavonols and polyphenols. Only flavonoid contents are associated with antiproliferative effects and cell membrane injury, while antioxidant properties are the result of polyphenol content. The data clearly demonstrate that individual Staphylea L. species differ, not only in the amount of biologically active compounds, but also by the extent of harmful and beneficial effects.

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“…With roots in both the doctrine of signatures and the idea of similia similibus curantur, the bloated fruits of bladdernut are believed to be an ailment against meteorism and pulmonary disorders, 95 the latter perhaps also infl uenced by the tradition of certain late medieval 96 Current research in medicinal uses of bladdernut aims to investigate the potential of certain secondary metabolites (polyphenols, fl avonoids, and hydroxycinnamic derivatives) for their possible antibacterial, antiproliferative, and antioxidant activities. 98 …”

Section: Medicinal Usesmentioning

confidence: 99%

A Fistful of Bladdernuts: The Shifting Uses ofStaphylea pinnataL. as Documented by Archaeology, History, and Ethnology

et al. 2014

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Research into the past cultural dimensions of plants is often restricted to plants with important uses, cultivated for millennia and ever sought after, and of fundamental meaning to human subsistence and economy. This is defi nitely true for the main cultivated crops of the Old World, and for plants regarded essential for other (e.g. medical) reasons. Bladdernut is defi nitely not one of these 'great' useful plants. Still, this shrub has had a curious past which seemed to us worth investigating, for the beliefs and meanings that still cling to it. As we will see, new beliefs are still developing.Largely building upon the previous detailed work by the fi rst author, 1 the current study pursues the goal of drawing as complete a picture as possible of the cultural relevance of bladdernut in past societies. This has been done by critically evaluating the extant literature on material evidence, written historical sources, and ethnographic studies on Staphylea pinnata across Europe, and trying to suggest new interpretations for this plant. Originally given as a conference paper by the fi rst author listed, the following article has been considerably reworked and now includes substantially more research than previously. keywords bladdernut, archaeobotany, historical botany, ethnobotany, ritual plant use, medicinal plants, food plants Downloaded by [84.251.91.165] at 15

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Antibacterial activity of plant extracts from the families Fabaceae, Oleaceae, Philadelphaceae, Rosaceae and Staphyleaceae

Cited by 28 publications

References 5 publications

Antiproliferative and Proapoptotic Activities of Methanolic Extracts from Ligustrum vulgare L. as an Individual Treatment and in Combination with Palladium Complex

Antiproliferative and Proapoptotic Activities of Methanolic Extracts from Ligustrum vulgare L. as an Individual Treatment and in Combination with Palladium Complex

Antiproliferative, Cytotoxic, Antioxidant Activity and Polyphenols Contents in Leaves of Four Staphylea L. Species

A Fistful of Bladdernuts: The Shifting Uses ofStaphylea pinnataL. as Documented by Archaeology, History, and Ethnology

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