Antibacterial Activity Test of Mangosteen Plants (Garcinia Mangostana L.): A Review

Andani, Rika; Fajrina, Anzharni; Asra, Ridho; Eriadi, Aried

doi:10.22270/ajprd.v9i1.927

Cited by 7 publications

(4 citation statements)

References 6 publications

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“…The phytochemicals present in the mangosteen leaf aqueous extract, such as xanthones, flavonoids and terpene [30][31][32][33], were responsible for the observed functional groups. These compounds played a crucial role as capping, stabilizing and reducing agents during the green synthesis of ZnO-CuO NCs, primarily through electrostatic and steric stabilization mechanisms [32,44].…”

Section: Discussionmentioning

confidence: 99%

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Impact of Diverse Parameters on the Physicochemical Characteristics of Green-Synthesized Zinc Oxide–Copper Oxide Nanocomposites Derived from an Aqueous Extract of Garcinia mangostana L. Leaf

Chan,

Aminuzzaman,

Tey

et al. 2023

Materials

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Compared to conventional metal oxide nanoparticles, metal oxide nanocomposites have demonstrated significantly enhanced efficiency in various applications. In this study, we aimed to synthesize zinc oxide–copper oxide nanocomposites (ZnO-CuO NCs) using a green synthesis approach. The synthesis involved mixing 4 g of Zn(NO3)2·6H2O with different concentrations of mangosteen (G. mangostana) leaf extract (0.02, 0.03, 0.04 and 0.05 g/mL) and 2 or 4 g of Cu(NO3)2·3H2O, followed by calcination at temperatures of 300, 400 and 500 °C. The synthesized ZnO-CuO NCs were characterized using various techniques, including a UV-Visible spectrometer (UV-Vis), photoluminescence (PL) spectroscopy, Fourier Transform Infrared (FTIR) spectroscopy, X-ray powder diffraction (XRD) analysis and Field Emission Scanning Electron Microscope (FE-SEM) with an Energy Dispersive X-ray (EDX) analyzer. Based on the results of this study, the optical, structural and morphological properties of ZnO-CuO NCs were found to be influenced by the concentration of the mangosteen leaf extract, the calcination temperature and the amount of Cu(NO3)2·3H2O used. Among the tested conditions, ZnO-CuO NCs derived from 0.05 g/mL of mangosteen leaf extract, 4 g of Zn(NO3)2·6H2O and 2 g of Cu(NO3)2·3H2O, calcinated at 500 °C exhibited the following characteristics: the lowest energy bandgap (2.57 eV), well-defined Zn-O and Cu-O bands, the smallest particle size of 39.10 nm with highest surface area-to-volume ratio and crystalline size of 18.17 nm. In conclusion, we successfully synthesized ZnO-CuO NCs using a green synthesis approach with mangosteen leaf extract. The properties of the nanocomposites were significantly influenced by the concentration of the plant extract, the calcination temperature and the amount of precursor used. These findings provide valuable insights for researchers seeking innovative methods for the production and utilization of nanocomposite materials.

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Section: Discussionmentioning

confidence: 99%

“…Mangosteen is a seasonal fruit in the Clusiacae family and is commonly found in tropical countries [25][26][27][28][29]. It contains numerous phytochemicals, such as xanthones, flavonoids and terpene [30][31][32][33], which have the potential to form stable colloidal nanomaterials.…”

Section: Introductionmentioning

confidence: 99%

Impact of Diverse Parameters on the Physicochemical Characteristics of Green-Synthesized Zinc Oxide–Copper Oxide Nanocomposites Derived from an Aqueous Extract of Garcinia mangostana L. Leaf

Chan,

Aminuzzaman,

Tey

et al. 2023

Materials

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“…Mangosteen. Mangosteen extract (ME) is derived from a tropical plant (Garcinia mangostana) which contains outstanding medicinal benefits such as anti-inflammatory, antioxidant, and antibacterial properties [146]. The phytochemical compounds contained in ME affect Gram-positive bacteria by inhibiting peptidoglycan synthesis [147].…”

Section: Glycopeptidesmentioning

confidence: 99%

Niosomal-Based Drug Delivery Platforms: A Promising Therapeutic Approach to Fight Staphylococcus aureus Drug Resistance

Hemmati,

Chegini,

Arabestani

2023

Journal of Nanomaterials

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Staphylococcus aureus, a prominent bacterial pathogen, presents formidable medical challenges owing to its rapid development of resistance. The emergence of multidrug resistant (MDR) S. aureus strains has become a pressing concern for healthcare systems, driving researchers to explore novel therapeutic strategies for managing infections associated with this pathogen. In this pursuit, niosomal-based platforms have emerged as promising candidates to effectively target S. aureus and fight conventional antimicrobial resistance. Niosomes comprise a bilayer membrane formed by nonionic surfactants, which can encapsulate both hydrophilic and hydrophobic drugs. These nanoparticles are known as vesicular delivery systems and have many advantages, such as low cost, less toxicity, and more flexibility and stability. Moreover, niosomes, being an effective drug delivery system, can directly interact with the bacterial cell envelope, thereby enhancing the pharmacokinetic activities of drugs at infected sites. A niosome-based delivery system can effectively treat S. aureus infections by destroying the biofilm community, increasing intracellular targeting, and enhancing the antibacterial activity. The main mechanisms of action of niosomes against resistant S. aureus strains involve the ability to resist enzymatic degradation, controlled release profile, and targeted drug delivery, which can provide an effective dosage of antimicrobial agents at the site of actions. In addition, niosomes have the potential to transfer wide-spectrum materials from different classes of antibiotics to nonantibiotic antimicrobial agents, such as natural compounds, antimicrobial peptides, and metallic nanoparticles. The combination of polymeric materials in the structure of a niosomal formulation could improve their bioavailability, loading capacity, and therapeutic efficacy for different applications. Furthermore, niosomes could find application in photodynamic therapy, offering a promising alternative to conventional treatments for eradicating drug-resistant S. aureus isolates. Finally, niosomal nanocarriers can be developed for delivering the drugs to desired sites by different routes of administration and could be considered a powerful strategy for overcoming the therapeutic obstacles caused by MDR S. aureus.

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“…It belongs to the Clusiacae family [ 47 , 48 ], and mangosteen has been described as the “fruit queen” due to its incomparable flavor and aroma [ 49 , 50 , 51 ]. The mangosteen contains large amounts of phenolics and antioxidants [ 52 , 53 , 54 , 55 ]. Mangosteen leaves especially contain large amounts of 1,5,8-trihydroxy-3-methoxy-2-(3-methylbut-2-enyl) xanthone and 1, 6-dihydroxy-3-methoxy-2-(3-methyl-2-buthenyl)-xanthone [ 56 ].…”

Section: Introductionmentioning

confidence: 99%

Effect of Calcination Temperature on Structural, Morphological and Optical Properties of Copper Oxide Nanostructures Derived from Garcinia mangostana L. Leaf Extract

et al. 2022

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Synthesis of copper oxide (CuO) nanostructures via biological approach has gained attention to reduce the harmful effects of chemical synthesis. The CuO nanostructures were synthesized through a green approach using the Garcinia mangostana L. leaf extract and copper (II) nitrate trihydrate as a precursor at varying calcination temperatures (200–600 °C). The effect of calcination temperatures on the structural, morphological and optical properties of CuO nanostructures was studied. The red shifting of the green-synthesized CuO nanoparticles’ absorption peak was observed in UV-visible spectrum, and the optical energy bandgap was found to decrease from 3.41 eV to 3.19 eV as the calcination temperatures increased. The PL analysis shown that synthesized CuO NPs calcinated at 500 °C has the maximum charge carriers separation. A peak located at 504–536 cm−1 was shown in FTIR spectrum that indicated the presence of a copper-oxygen vibration band and become sharper and more intense when increasing the calcination temperature. The XRD studies revealed that the CuO nanoparticles’ crystalline size was found to increase from 12.78 nm to 28.17 nm, and dislocation density decreased from 61.26 × 1014 cm−1 to 12.60 × 1014 cm−1, while micro strain decreased from 3.40 × 10−4 to 1.26 × 10–4. From the XPS measurement, only CuO single phase without impurities was detected for the green-mediated NPs calcinated at 500 °C. The morphologies of CuO nanostructures were examined using FESEM and became more spherical in shape at elevated calcination temperature. More or less spherical nanostructure of green-mediated CuO calcinated at 500 °C were also observed using TEM. The purity of the green-synthesized CuO nanoparticles was evaluated by EDX analysis, and results showed that increasing calcination temperature increases the purity of CuO nanoparticles.

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Antibacterial Activity Test of Mangosteen Plants (Garcinia Mangostana L.): A Review

Cited by 7 publications

References 6 publications

Impact of Diverse Parameters on the Physicochemical Characteristics of Green-Synthesized Zinc Oxide–Copper Oxide Nanocomposites Derived from an Aqueous Extract of Garcinia mangostana L. Leaf

Impact of Diverse Parameters on the Physicochemical Characteristics of Green-Synthesized Zinc Oxide–Copper Oxide Nanocomposites Derived from an Aqueous Extract of Garcinia mangostana L. Leaf

Niosomal-Based Drug Delivery Platforms: A Promising Therapeutic Approach to Fight Staphylococcus aureus Drug Resistance

Effect of Calcination Temperature on Structural, Morphological and Optical Properties of Copper Oxide Nanostructures Derived from Garcinia mangostana L. Leaf Extract

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