Antibacterial adhesive self-healing hydrogels to promote diabetic wound healing

Chen, Jueying; He, Jiahui; Yang, Yanjing; Qiao, Lipeng; Hu, Juan; Zhang, Jie; Guo, Baolin

doi:10.1016/j.actbio.2022.04.041

Cited by 230 publications

(118 citation statements)

References 78 publications

Supporting

Mentioning

114

Contrasting

Unclassified

Order By: Relevance

“…And this peak shifted to a lower wavenumber in the spectrum of AGAR@PVA–TA hydrogels with the increase of TA concentration in hydrogel indicating the formation of hydrogen bands between TA and PVA and agar. 40,41 It was also possible to find a clear peak at 1210 cm −1 for all AGAR@PVA–TA specimens, which is a bending vibration of the phenolic hydroxyl group and further proves the successful loading of TA.…”

Section: Resultsmentioning

confidence: 58%

An agar–polyvinyl alcohol hydrogel loaded with tannic acid with efficient hemostatic and antibacterial capacity for wound dressing

Cheng

Peng

Xi³

et al. 2022

Food Funct.

View full text Add to dashboard Cite

show abstract

Section: Resultsmentioning

confidence: 58%

An agar–polyvinyl alcohol hydrogel loaded with tannic acid with efficient hemostatic and antibacterial capacity for wound dressing

Cheng

Peng

Xi³

et al. 2022

Food Funct.

View full text Add to dashboard Cite

show abstract

“…Good biocompatibility is the basic requirement of medical dressings. , Hemocompatibility testing and cytocompatibility testing are the most common methods for evaluating the biocompatibility of hydrogel materials Figure b shows the results of hemocompatibility.…”

Section: Resultsmentioning

confidence: 99%

Bacterial Growth-Induced Tobramycin Smart Release Self-Healing Hydrogel for Pseudomonas aeruginosa-Infected Burn Wound Healing

et al. 2022

Self Cite

View full text Add to dashboard Cite

Burns are a common health problem worldwide and are highly susceptible to bacterial infections that are difficult to handle with ordinary wound dressings. Therefore, burn wound repair is extremely challenging in clinical practice. Herein, a series of self-healing hydrogels (QCS/OD/TOB/PPY@PDA) with good electrical conductivity and antioxidant activity were prepared on the basis of quaternized chitosan (QCS), oxidized dextran (OD), tobramycin (TOB), and polydopaminecoated polypyrrole nanowires (PPY@PDA NWs). These Schiff base crosslinks between the aminoglycoside antibiotic TOB and OD enable TOB to be slowly released and responsive to pH. Interestingly, the acidic substances during the bacteria growth process can induce the on-demand release of TOB, avoiding the abuse of antibiotics. The antibacterial results showed that the QCS/OD/TOB/PPY@PDA9 hydrogel could kill high concentrations of Pseudomonas aeruginosa (PA), Staphylococcus aureus, and Escherichia coli in a short time and showed a bactericidal effect for up to 11 days in an agar plate diffusion experiment, while showing good in vivo antibacterial activity. Excellent and long-lasting antibacterial properties make it suitable for severely infected wounds. Furthermore, the incorporation of PPY@PDA endowed the hydrogel with near-infrared (NIR) irradiation assisted bactericidal activity of drug-resistant bacteria, conductivity, and antioxidant activity. Most importantly, in the PA-infected burn wound model, the QCS/OD/TOB/PPY@PDA9 hydrogel more effectively controlled wound inflammation levels and promoted collagen deposition, vascular generation, and earlier wound closure compared to Tegaderm dressings. Therefore, the TOB smart release hydrogels with on-demand delivery are extremely advantageous for bacterial-infected burn wound healing.

show abstract

“…As shown in Figure e,f, the PDG hydrogel-treated wounds had the fastest recovery on day 10, and the average wound closure area was significantly larger than those in the control and PT hydrogel groups. This could possibly be attributed to the close fit of the PDG hydrogel to the wound defect, benefiting from the good injectability and in situ gelation allowed by the internal gelation method and excellent tissue adhesion, which protected the underlying wound from external microorganisms. , On the 15th day, the animals in the PDG hydrogel group had the largest wound closure area. To further characterize the healing process, H&E (Figure g) and Masson’s trichrome staining (Figure h) were carried out to evaluate the quality of the regenerated skin tissues.…”

Section: Resultsmentioning

confidence: 99%

Biomineralization-Inspired Intermediate Precursor for the Controllable Gelation of Polyphenol–Macromolecule Hydrogels

Tang

Wang

et al. 2022

ACS Appl. Mater. Interfaces

View full text Add to dashboard Cite

Hydrogels composed of polyphenols and various macromolecules have been widely reported to have the advantage of facile preparation, mainly through the formation of hydrogen bonds. However, the traditional preparation method involves the direct mixing of polyphenols and macromolecules, which generally occurs too quickly and uncontrollably, and results in poor homogeneity, injectability, and shape designability. Here, inspired by the intermediate precursor during biomineralization, to facilitate transformation in a controllable way, we propose a novel and universal internal gelation method that creates an intermediate precursor by controlling the pH value to manipulate the elimination and generation of hydrogen bonds between a polyphenol and macromolecules. The precursor strategy greatly improves the homogeneity, injectability, and shape designability of the hydrogel while also achieving a controllable gelation process, and the gelation time can be accurately adjusted. The hydrogels prepared with this method exhibited superior capability to seal leaks, provided complete wound coverage, and showed the potential to be a shape-designable wearable strain sensor. Our study opens up a new way to construct and apply polyphenol–macromolecule hydrogels in a more controllable manner.

show abstract

Antibacterial adhesive self-healing hydrogels to promote diabetic wound healing

Cited by 230 publications

References 78 publications

An agar–polyvinyl alcohol hydrogel loaded with tannic acid with efficient hemostatic and antibacterial capacity for wound dressing

An agar–polyvinyl alcohol hydrogel loaded with tannic acid with efficient hemostatic and antibacterial capacity for wound dressing

Bacterial Growth-Induced Tobramycin Smart Release Self-Healing Hydrogel for Pseudomonas aeruginosa-Infected Burn Wound Healing

Biomineralization-Inspired Intermediate Precursor for the Controllable Gelation of Polyphenol–Macromolecule Hydrogels

Contact Info

Product

Resources

About