Antibacterial and Antibiofilm Activities of Ceragenins against &lt;i&gt;Pseudomonas aeruginosa&lt;/i&gt; Clinical Isolates

Güzel, Çağla Bozkurt; Hacıoğlu, Mayram; Inci, Gozde; Savage, Paul B.

doi:10.4274/tjps.galenos.2018.59023

Cited by 5 publications

(4 citation statements)

References 30 publications

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“…Biofilm is also an important factor in S. maltophilia infections, [48] and the anti-biofilm effects of ceragenins suggest that they have the potential for application against S. maltophilia strains [19,49]. The high anti-biofilm activity of ceragenins is confirmed by many previous studies [50][51][52]. For example, Chmielewska et al demonstrated the effective action of CSA-13, CSA-44 and CSA-131 against biofilm produced by the NDM-1 (New Delhi metallo-β-lactamase-1) producing strains Escherichia coli BAA-2471, Enterobacter cloacae BAA-2468, and Klebsiella pneumoniae BAA-2472 I BAA-2473 [53].…”

Section: Discussionsupporting

confidence: 52%

Bactericidal Activity of Ceragenin in Combination with Ceftazidime, Levofloxacin, Co-Trimoxazole, and Colistin against the Opportunistic Pathogen Stenotrophomonas maltophilia

et al. 2022

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Background: Stenotrophomonas maltophilia (S. maltophilia) is an emerging opportunistic Gram-negative rod causing nosocomial infections predominantly in immunocompromised patients. Due to its broad intrinsic resistance to antibiotics, including carbapenems and the ability to form a biofilm, it is difficult to eradicate. Methods: In this study, the benefit of combined administration (potential synergism) and anti-biofilm activity of ceragenins: CSA-13, CSA-44, and CSA-131 (synthetic mimics of natural antimicrobial peptides) with ceftazidime, levofloxacin, co-trimoxazole and colistin against clinical strains of S. maltophilia were determined using MIC/MBC (minimum inhibitory concentration/minimum bactericidal concentration), killing assays and CV staining. Results: Obtained data indicate that the ceragenins exhibit strong activity against the tested strains of S. maltophilia grown in planktonic culture and as stationary biofilms. Moreover, with some strains, the synergy of ceragenins with conventional antibiotics was observed Conclusion: Our data suggest that ceragenins are promising agents for future development of new methods for treatment of infections caused by S. maltophilia, along with its potential use in combination with conventional antibiotics.

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Section: Discussionsupporting

confidence: 52%

Bactericidal Activity of Ceragenin in Combination with Ceftazidime, Levofloxacin, Co-Trimoxazole, and Colistin against the Opportunistic Pathogen Stenotrophomonas maltophilia

et al. 2022

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“…As ceragenins have been described to disrupt fungal membranes, this was investigated as a potential mode of action of DOCA-NH 2 . 8,11,31…”

Section: Resultsmentioning

confidence: 99%

Insights into the antimicrobial properties of a cationic steroid and antibiofilm performance in PDMS-based coatings to potentially treat urinary infections

Neves¹,

Freitas-Silva²,

Durães³

et al. 2023

J. Mater. Chem. B

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“…Even though CSA-13 shows better activity than CSA-142 and CSA-192, second-generation ceragenins might be more beneficial than the first-generation due to better stability, environmentally friendly, and easier preparation [ 144 ]. Another second-generation ceragenins—CSA-131—exhibited bactericidal and excellent antibiofilm properties against P. aeruginosa [ 145 ] and S. maltophilia [ 146 ] as well as a synergistic activity when combined with colistin against CRAB [ 147 ].…”

Section: Newly Prospective Pharmaceutical Candidates To Mitigate Antimicrobial Resistancementioning

confidence: 99%

Pharmaceutical Approaches on Antimicrobial Resistance: Prospects and Challenges

et al. 2021

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The rapid increase in pathogenic microorganisms with antimicrobial resistant profiles has become a significant public health problem globally. The management of this issue using conventional antimicrobial preparations frequently results in an increase in pathogen resistance and a shortage of effective antimicrobials for future use against the same pathogens. In this review, we discuss the emergence of AMR and argue for the importance of addressing this issue by discovering novel synthetic or naturally occurring antibacterial compounds and providing insights into the application of various drug delivery approaches, delivered through numerous routes, in comparison with conventional delivery systems. In addition, we discuss the effectiveness of these delivery systems in different types of infectious diseases associated with antimicrobial resistance. Finally, future considerations in the development of highly effective antimicrobial delivery systems to combat antimicrobial resistance are presented.

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Antibacterial and Antibiofilm Activities of Ceragenins against <i>Pseudomonas aeruginosa</i> Clinical Isolates

Cited by 5 publications

References 30 publications

Bactericidal Activity of Ceragenin in Combination with Ceftazidime, Levofloxacin, Co-Trimoxazole, and Colistin against the Opportunistic Pathogen Stenotrophomonas maltophilia

Bactericidal Activity of Ceragenin in Combination with Ceftazidime, Levofloxacin, Co-Trimoxazole, and Colistin against the Opportunistic Pathogen Stenotrophomonas maltophilia

Insights into the antimicrobial properties of a cationic steroid and antibiofilm performance in PDMS-based coatings to potentially treat urinary infections

Pharmaceutical Approaches on Antimicrobial Resistance: Prospects and Challenges

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