Antibacterial and antifungal effects of chitosan nanoparticles on tissue conditioners of complete dentures

Mousavi, Seyed Amin; Ghotaslou, Reza; Kordi, Shirafkan; khoramdel, azin; Aeenfar, Ali; Kahjough, Sona Talaei; Akbarzadeh, Abolfazl

doi:10.1016/j.ijbiomac.2018.06.151

Cited by 61 publications

(36 citation statements)

References 18 publications

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“…Today, there is a growing trend in targeted therapy with nanoparticles. 29,30 Several studies have also shown that the most important fragments of KDR3 for antibody production are the first to the third domains, especially the third domain. 12,13 In the light of previous studies, a segment of the KDR3 was also selected with regard to its accessibility and design for peptide synthesis.…”

Section: Discussionmentioning

confidence: 99%

Isolation of a novel Anti-KDR3 Single-chain Variable Fragment Antibody from a Phage Display Library

Kordi

Rahmati-Yamchi

Vostakolaei

et al. 2019

IJAAI

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Vascular endothelial growth factor receptor 2 (VEGFR-2) is known as one of the important antigens playing a vital role in angiogenesis. In this study, phage display technology (PDT) was used to produce a single-chain variable fragment (scFv) antibody against a region of the domain 3 in VEGFR-2 called kinase insert domain receptor 3 (KDR3). After designing the KDR3 peptide and biopanning, a colony was chosen for scFv antibody expression. Following expression and purification; western blotting, dot blotting and immunofluorescence (IF) were used to evaluate the antibody function. Surface plasmon resonance (SPR) was also employed to measure affinity of produced antibody. Once a colony was selected and transferred to the expression host, the scFv antibody was expressed in the expected range of 28 kDa. Using a designed chromatography column, antibody purification was found to be about 95%. In this study, a novel scFv with the capability of binding to KDR3 was isolated and purified and its intracellular function was investigated and verified.

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Section: Discussionmentioning

confidence: 99%

Isolation of a novel Anti-KDR3 Single-chain Variable Fragment Antibody from a Phage Display Library

Kordi

Rahmati-Yamchi

Vostakolaei

et al. 2019

IJAAI

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“…Wearing removable/complete dentures for a long term is prone to microbial aggregation, which can lead to denture stomatitis [131]. Polymethyl methacrylate (PMMA) has been the most common utilized biomaterial for removable partial or complete dentures, although it exhibits relatively poor antimicrobial properties [132].…”

Section: Antimicrobial Applications In Dentistrymentioning

confidence: 99%

“…As organic polymers, chitosan and graphene oxide are well known for their antibacterial properties. The application of chitosan NPs effectively inhibited fungal and bacterial growth within 48 hours [131]. Graphene oxide incorporated into PMMA had long term antimicrobial-adhesive effects without compromising mechanical properties [146].…”

Section: Antimicrobial Applications In Dentistrymentioning

confidence: 99%

Application of Antimicrobial Nanoparticles in Dentistry

2019

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Oral cavity incessantly encounters a plethora of microorganisms. Plaque biofilm—a major cause of caries, periodontitis and other dental diseases—is a complex community of bacteria or fungi that causes infection by protecting pathogenic microorganisms from external drug agents and escaping the host defense mechanisms. Antimicrobial nanoparticles are promising because of several advantages such as ultra-small sizes, large surface-area-to-mass ratio and special physical and chemical properties. To better summarize explorations of antimicrobial nanoparticles and provide directions for future studies, we present the following critical review. The keywords “nanoparticle,” “anti-infective or antibacterial or antimicrobial” and “dentistry” were retrieved from Pubmed, Scopus, Embase and Web of Science databases in the last five years. A total of 172 articles met the requirements were included and discussed in this review. The results show that superior antibacterial properties of nanoparticle biomaterials bring broad prospects in the oral field. This review presents the development, applications and underneath mechanisms of antibacterial nanoparticles in dentistry including restorative dentistry, endodontics, implantology, orthodontics, dental prostheses and periodontal field.

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“…CHT-NMs resist micro-organisms growth by applying numerous ways, so resistance to chitosan-NMs is not expected. 76 Following are the mechanisms in combating bacterial resistance: 1) Removal of acetyl group done on CHT, a derivative of chitin, ie, elongated polymeric series of N-acetyl-glucosamine remnants. Thus, CHT is known to be polymeric extensive sequence having arbitrary residues of glucosamine and N-acetyl-glucosamine placed irregularly.…”

Section: Nanomaterials Mechanisms To Combat Bacterial Resistancementioning

confidence: 99%

<p>Recent Advances in Nanotechnology-Aided Materials in Combating Microbial Resistance and Functioning as Antibiotics Substitutes</p>

Munir

Ahmed

Usman

et al. 2020

IJN

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The ongoing escalation of drug-resistant bacteria creates the leading challenges for human health. Current predictions show that deaths due to bacterial illness will be more in comparison to cancer in 2050. Irrational use of antibiotics, prolonged regimen and using as a prophylactic treatment for various infections are leading cause of microbial resistance. It is an emerging approach to introduce evolving nanomaterials (NMs) as a base of antibacterial therapy to overcome the bacterial resistance pattern. NMs can implement several bactericidal ways and turn into a challenge for bacteria to survive and develop resistance against NMs. All the pathways depend on the surface chemistry, shape, core material and size of NMs. Because of these reasons, NMs based stuff shows a critical role in advancing the treatment efficiency by interacting with the cellular system of bacteria and functioned as an antibiotic substitute. We divided this review into two sections. The first part highlights the development of microbial resistance to antibiotics and their mechanisms. The second section details the NMs mechanisms to combat antibiotic resistance. In short, we try to summarize the advances in NMs role to deal with microbial resistance and giving solution as antibiotics substitute.

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Antibacterial and antifungal effects of chitosan nanoparticles on tissue conditioners of complete dentures

Cited by 61 publications

References 18 publications

Isolation of a novel Anti-KDR3 Single-chain Variable Fragment Antibody from a Phage Display Library

Isolation of a novel Anti-KDR3 Single-chain Variable Fragment Antibody from a Phage Display Library

Application of Antimicrobial Nanoparticles in Dentistry

<p>Recent Advances in Nanotechnology-Aided Materials in Combating Microbial Resistance and Functioning as Antibiotics Substitutes</p>

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