Antibacterial and biocompatible properties of vancomycin-loaded nano-hydroxyapatite/collagen/poly (lactic acid) bone substitute

Biologically Inspired Collagen/Apatite Composite Biomaterials for Potential Use in Bone Tissue Regeneration—A Review

“…For this reason, composite materials began to be used as drug delivery systems to achieve greater therapeutic effects. There are studies which describe the introduction of anti-resorptive drugs, anti-cancer drugs, antibiotics, proteins or genes [89][90][91][92][93][94][95]. It is worth mentioning that infections occurring in the implant area are a major problem in orthopedic surgery.…”

Tailoring the morphological features of sol–gel synthesized mesoporous hydroxyapatite using fatty acids as an organic modifier

“…47 A calibration curve for the standard concentration of the drug is very important in analyzing the discharge rate of the drug from nanoparticles in an appropriate medium. 48 A known concentration (2-10 mg mL À1 ) of MT was scanned using a UV-visible spectrophotometer. For MT having a concentration in the range of 2-10 mg mL À1 , a prominent peak at 207 nm was noticed.…”

Nanoparticulate Platforms for Targeting Bone Infections: Meeting a Major Therapeutic Challenge

“…In the first case, nanosized HA is generally associated with biodegradable polymers, such as alginate, polylactic acid and PLGA, in order to obtain a sustained antibiotic release and a prolonged antibacterial effect without hindering its biocompatibility. As an example, the preparation of a nanosized HA-collagen-polylactic acid composite loaded with vancomycin showed a sustained drug release up to 4 weeks with a high in vitro antibacterial activity against S. aureus for up to 18 days [38]. The association of alginate microspheres with nanoHA also allowed a sustained release amoxicillin and erythromycin thus prolonging the in vitro antibacterial activity against E. coli and S. aureus for up to 28 days [42].…”