Antibacterial and immunomodulator activities of virgin coconut oil (VCO) against Staphylococcus aureus

Widianingrum, Desy Cahya; Noviandi, Cuk Tri; Salasia, Siti Isrina Oktavia

doi:10.1016/j.heliyon.2019.e02612

Cited by 62 publications

(62 citation statements)

References 29 publications

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“…Lauric acid can also damage bacterial cell membranes so that they interfere with protein signaling for bacterial cell growth. 13,14 As a result, bacteria will die. The reduced number of colony staphylococcus will be accompanied by a reduction in the thickness of the biofilm layer in the wound.…”

Section: Discussionmentioning

confidence: 99%

Reduction of Staphylococcus aureus bacteria collaboration in diabetic ulcers by giving virgin coconut oil

Nur¹,

Anggraini²,

Dafriani³

et al. 2020

Int J Community Med Public Health

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Background: Diabetic ulcers often result in amputations. The bacteria found in diabetic ulcers are Enterobacter sp, Staphylococcus aureus, Salmonella sp and Pseudomonas sp. Nursing management of ulcer patients has been attempted but nothing has been effective yet. Using virgin coconut oil (VCO) contains anti-inflammatory, antipyretic and has an analgesic effect to increase the formation of new blood vessels with faster wound healing. Aim was to study the effect of wound care by giving VCO on the colonization of Staphylococcus aureus bacteria in diabetic ulcers.Methods: Quasi-experimental research with the two-group pre-test and post-test design approach involved 36 diabetic ulcer patients with consecutive sampling by doing wound care for 4 days. The duration of treatment was 30-40 minutes. Data was taken by swab on wound fluid before and after the intervention. Bivariate analysis carried out t-independent test of DM ulcers.Results: The results showed the average number of colony staphylococcus in the intervention group before being given wound care with VCO 72.88, while after being treated with 38.88 wound VCO and the average results of the number of colony staphylococcus in the control group before being treated with NaCl 77.88, whereas after being treated with VCO 38.88 wound with NaCl 72.88 in the statistical test the p value is 0,000.Conclusions: There was a significant influence between the number of colony Staphylococcus in the control group and the intervention group.

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Section: Discussionmentioning

confidence: 99%

Reduction of Staphylococcus aureus bacteria collaboration in diabetic ulcers by giving virgin coconut oil

Nur¹,

Anggraini²,

Dafriani³

et al. 2020

Int J Community Med Public Health

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“…56 El ácido láurico (C12:0), tiene la mayor actividad antiviral y antibacteriana, debido a que desintegra las paredes celulares bacterianas, 56 como lo indicó Yang et al (2018) 57 en un estudio con Clostridium difficile, donde se evaluó su efecto inhibidor a una concentración de 0.1 mg/mL, y se observó una cantidad mayor de materiales de ácido nucleico comparado con el control, lo cual indica que el ácido láurico (C12:0) daña la integridad de la membrana celular. Windianingrum et al (2019) 58 demostraron el potencial antibacteriano del aceite de coco virgen sobre el crecimiento de Staphylococcus aureus, el cual inhibió con una concentración mínima de 200 μL, debido a la presencia de este componente (40-60%), que se encuentra en su aceite en forma de ácidos grasos libres y monoglicéridos, además, de tener una actividad antibacteriana, antiviral, antifúngica, antiprotozoaria, también puede mejorar el sistema inmunológico. Por otra parte, Matsue et al (2019) 53 determinaron la actividad microbiana del ácido láurico (C12:0) contra S. agalactiae, S. mutans, S. pneumoniae, S. pyogenes, S. salivarius y S. sanguinis, y demostraron que la adición de éste ácido a una concentración de 0.25 mM y 2.5 mM inhibió su proliferación.…”

Section: áCidos Grasos De Cadena Corta Y Media Como Precursores Para Inhibir Los Síntomas Del Coronavirusunclassified

Ácidos grasos de cadena corta y media como precursores para inhibir los síntomas del coronavirus

Mateos-Islas

Ventura-Pérez

Ariza‐Ortega

2021

ICSA

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Los ácidos grasos de cadena corta (acético C2:0, propiónico C3:0 y butírico C4:0) y media (caproico C6:0, caprílico C8:0, cáprico C10:0 y láurico C12:0), se originan por la fermentación de la ingesta de fibra en la dieta, llevada a cabo por los microorganismos en el tracto intestinal, y se encuentra en algunos alimentos, su consumo ejerce un efecto antiinflamatorio y antiviral, en virtud de que reducen la expresión de citocinas proinflamatorias como TNF-α, IL-6 e IL-12 y la mediación de IL-10 y son antimicrobianos contra hongos, virus y bacterias debido a que destruyen su membrana celular respectivamente. El objetivo de este trabajo fue revisar el efecto de los ácidos grasos de cadena corta y media, como precursores para inhibir los síntomas del coronavirus. Se ha realizado una búsqueda bibliográfica a través de bases de datos electrónicas y estudios han demostrado que los C2:0, C3:0 y C4:0 a una concentración de 200 mM, 50 mM y 5 mM respectivamente, reducen la inflamación mediante la activación de varios GPCR, que suprimen la expresión de moléculas de adhesión en células inflamatorias y células endoteliales, previniendo la quimiotaxis de monocitos en el sitio inflamatorio. Mientras que el C12:0 a 250 mM es antimicrobiano e inhibe la etapa de maduración tardía del ciclo de replicación del virus. En conclusión, la ingesta de C2:0, C3:0, C4:0 y C12:0 podría disminuir o inhibir los síntomas de la familia del coronavirus, como es el COVID-19.

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“…This decreasing in the number of colony in the second examination of control group occurred because the activity of anti-candida effect posed by VCO which cause disintegration of fungal cell plasma membrane. [15][16][17] Unsaturated fatty acid contained in VCO is as much as 60%, consist of medium-chain fatty acid which is essential for health body. The saturated fatty acid (lauric acid and capric acid) posed its antimicrobe activity so that after the administration of VCO orally or topically, it decreases the number of colonies on pregnant woman leucorrhea.…”

Section: Difference In the Number Of Candida Albicans Colonies In Pregnant Women Between Intervention Group And Control Group With Adminimentioning

confidence: 99%

“…Besides, this material is safe and low cost so that it can be used as alternative to synthetic agent that is recently used. [15][16][17]…”

Section: Difference In the Number Of Candida Albicans Colonies In Pregnant Women Between Intervention Group And Control Group With Adminimentioning

confidence: 99%

Effect of Virgin Coconut Oil in The Treatment of Leucorrhea Caused by Candida Albicans Infection on Pregnant Women at Hospitals in Padang

Zen

Desmiwarti

Syukur

2021

AOJ

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Introduction : According to WHO, the prevalence of reproductive health problems in women has reached 33% from all types of diseases. One of the most frequent reproductive health problems is fluor albus. The incidence of candidiasis in pregnant women has doubly increased, especially at third trimester, compared to women who were not pregnant. Candida should be considered a dangerous pathogen in early pregnancy.Objective : This study compared the number of colonies before and after the administration of virgin coconut oil (VCO) to address vaginal discharge caused by C. albicans infection in pregnant women.Material and methods : This is an experimental study on 36 pregnant women. Examination of fluor albus is done by applying vaginal swab before and after administration of 1 tablespoon of VCO orally three times a day dan 5cc of VCO was applied on the vagina and vulva for intervention group, meanwhile the control group was not given anything. Statistical analysis to test the significance is done by using T-test.Results : There was a difference on average number of colonies with higher number of colonies prior to administration (137.17 ± 16.35 vs 122.17 ± 14.42). The average number of colonies at the first examination was 96.06 ± 8.85 colonies and increased at the second examination to 112.89 ± 12.49 colonies.Conclusion : There was an effect of VCO administration on decreasing the number of colonies in the intervention group (p=0.000), while in control group, there was increasing average number of colonies in the second examination (p=0.000).Keywords: Candida albicans, fluor albus, pregnant women, virgin coconut oil

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Antibacterial and immunomodulator activities of virgin coconut oil (VCO) against Staphylococcus aureus

Cited by 62 publications

References 29 publications

Reduction of Staphylococcus aureus bacteria collaboration in diabetic ulcers by giving virgin coconut oil

Reduction of Staphylococcus aureus bacteria collaboration in diabetic ulcers by giving virgin coconut oil

Ácidos grasos de cadena corta y media como precursores para inhibir los síntomas del coronavirus

Effect of Virgin Coconut Oil in The Treatment of Leucorrhea Caused by Candida Albicans Infection on Pregnant Women at Hospitals in Padang

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