Antibacterial, antifungal, and anticancer potential of two-dimensional Ti3C2Tx MXene

Ahamed, Maqusood; Akhtar, Mohd Javed; Khan, Muhammad Aslam; Karuppiah, Ponmurugan

doi:10.1016/j.matlet.2022.133020

Cited by 15 publications

(7 citation statements)

References 15 publications

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“…[35] FTIR spectrum of prepared Mxene exhibited a typical peak at 1631 cm −1 , which was assigned to C=O group stretching vibrations. [40] In case of LPFEG-Mxene xerogel, all these bands did not display much significant change in position but intensity of bands decreases significantly. The broadband region in the range of 3200-3500 cm −1 represents typical peaks corresponding to -OH and NH groups of Mxene and LPFEG gelator.…”

Section: Structural Analysismentioning

confidence: 89%

Mxene‐Based Supramolecular Composite Hydrogels for Antioxidant and Photothermal Antibacterial Activities

Riaz

Baddi

Gao

et al. 2023

Macromolecular Bioscience

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Bacterial infections and oxidative damage caused by various reactive oxygen species (ROS) pose a significant threat to human health. It is highly desirable to find an ideal biomaterial system with broad spectrum antibacterial and antioxidant capabilities. A new supramolecular antibacterial and antioxidant composite hydrogel made of chiral L‐phenylalanine‐derivative (LPFEG) as matrix and Mxene (Ti3C2Tx) as filler material is presented. The noncovalent interactions (H‐bonding and π–π interactions) in between LPFEG and Mxene and the inversion of LPFEG chirality are verified by Fourier transform infrared and circular dichroism spectroscopy. The composite hydrogels show improved mechanical properties revealed by rheological analysis. The composite hydrogel system exhibits photothermal conversion efficiency (40.79%), which enables effective photothermal broad‐spectrum antibacterial activities against both Gram‐positive (Staphylococcus aureus) and Gram‐negative (Escherichia coli, Pseudomonas aeruginosa) bacteria. Furthermore, the Mxene also enables the composite hydrogel to exhibit excellent antioxidant activity by efficiently scavenging free radicals like DPPH•, ABTS•+, and •OH. These results indicate that the Mxene‐based chiral supramolecular composite hydrogel, with improved rheological, antibacterial, and antioxidant properties has a great potential for biomedical applications.

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Section: Structural Analysismentioning

confidence: 89%

Mxene‐Based Supramolecular Composite Hydrogels for Antioxidant and Photothermal Antibacterial Activities

Riaz

Baddi

Gao

et al. 2023

Macromolecular Bioscience

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“…Though these cell-based assays suggest that Ti 3 C 2 T x nanosheets have decent compatibility toward RBCs and HUVECs, the much-complicated in vivo toxicity still needs to be thoroughly examined. Because there are several previous literature studies that have demonstrated that different cell lines show distinct tolerance to the treatment dose of Ti 3 C 2 T x nanosheets. ,− The biodistribution of Ti 3 C 2 T x nanosheets also needs to be clearly identified when they were administered into the body by different routes. In addition, Ti 3 C 2 T x nanosheets can be degraded to small species (e.g., titanium dioxide, carbon, and other small species) via oxidation reaction with oxidizing agents, when exposed to air, water, or organic solvents. ,,− This suggests that the biotransformation of Ti 3 C 2 T x nanosheets in physiological environments and its potential risk to the body also should be considered.…”

Section: Discussionmentioning

confidence: 99%

“…Mahmoud et al have demonstrated that Ti 3 C 2 T x has good antibacterial properties and is a potential antibacterial agent. Ahamed et al have illustrated the antifungal function of Ti 3 C 2 T x . In addition, Ti 3 C 2 T x and other MXene materials have been applied in the photothermal therapy of tumors owing to their high photothermal conversion efficiency .…”

Section: Introductionmentioning

confidence: 99%

“…They can trigger serving cytotoxicity at a much lower treatment concentration (100 μg/mL) via disruption of autophagy. Interestingly, Ti 3 C 2 T x nanosheets exhibited higher toxic effects on cancerous cells (A549, A375, MCF7, and HeLa) over normal cells (MRC-5, HaCaT, IMR90, MCF10A, and human fibroblasts) due to their relative stronger capability to provoke a higher intracellular ROS level and adhesion to cell membranes of cancer cells. ,, In addition, Ti 3 C 2 T x nanosheets demonstrated high cytotoxicity with primary neural stem cells (NSCs) and NSC-derived differentiated cells . On treatment at 25 μg/mL, they can elicit significant cytotoxicity via the destruction of cell membranes.…”

Section: Introductionmentioning

confidence: 99%

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Cytocompatibility of Ti₃C₂T_x MXene with Red Blood Cells and Human Umbilical Vein Endothelial Cells and the Underlying Mechanisms

Huang

Hou

et al. 2023

Chem. Res. Toxicol.

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Two-dimensional (2D) nanomaterials have been widely used in biomedical applications because of their biocompatibility. Considering the high risk of exposure of the circulatory system to Ti3C2T x , we studied the cytocompatibility of Ti3C2T x MXene with red blood cells (RBCs) and human umbilical vein endothelial cells (HUVECs) and showed that Ti3C2T x had excellent compatibility with the two cell lines. Ti3C2T x at a concentration as high as 200 μg/mL caused a negligible percent hemolysis of 0.8%. By contrast, at the same treatment concentration, graphene oxide (GO) caused a high percent hemolysis of 50.8%. Scanning electron microscopy revealed that RBC structures remained intact in the Ti3C2T x treatment group, whereas those in the GO group completely deformed, sunk, and shrunk, which resulted in the release of cell contents. This difference can be largely ascribed to the distinct surficial properties of the two nanosheets. In specific, the fully covered surface-terminating −O and −OH groups leading to Ti3C2T x had a very hydrophilic surface, thereby hindering its penetration into the highly hydrophobic interior of the cell membrane. However, the strong direct van der Waals attractions coordinated with hydrophobic interactions between the unoxidized regions of GO and the lipid hydrophobic tails can still damage the integrity of the cell membranes. In addition, the sharp and keen-edged corners of GO may also facilitate its relatively strong cell membrane damage effects than Ti3C2T x . Thus, the excellent cell membrane compatibility of Ti3C2T x nanosheets and their ultraweak capacity to provoke excessive ROS generation endowed them with much better compatibility with HUVECs than GO nanosheets. These results indicate that Ti3C2T x has much better cytocompatibility than GO and provide a valuable reference for the future biomedical applications of Ti3C2T x .

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“…By comparison with conventional two-dimensional materials (such as graphene oxide), MXene also shows better antibacterial properties, especially in terms of gram-positive and gram-negative bacteria. 12,13 However, because of the low length-to-width ratio, directly assembling MXene nanosheets into the desired macrostructure with the ability of monitoring in real time is difficult, thus limiting their applications. 14 Therefore, MXene displays excellent electrical and mechanical properties, and can be formed in the formats of large areas, the suitable utility of flexible bio-integrated platforms.…”

Section: Introductionmentioning

confidence: 99%

Smart MXene‐based bioelectronic devices as wearable health monitor for sensing human physiological signals

Han

Zou

et al. 2023

VIEW

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Biosafe wearable healthcare monitor has attracted significant attention owing to their applicability to wearable electronics. However, the narrow sensing range and poor response limit the application of flexible devices for comprehensive monitoring of human health‐related physiological signals (i.e., pulse diagnosis). Critical challenges remain in the development of biocompatible materials and the design of flexible bio‐integrated platforms for these purposes, targeting performance approaching those of conventional wafer‐based technologies and long‐term operational stability. In this context, this work presents a robust and flexible MXene/polydopamine (PDA)‐composite‐film‐based pressure sensor in a portable/wearable fashion, which establishes a unique intercalated spherical‐like PDA molecules structure, thereby resulting in excellent sensing performance. The MXene/PDA‐based pressure sensor has sensitivity of up to 138.8 kPa−1 in the pressure range of 0.18–6.20 kPa with fast response and recovery speed (t1 < 100 ms; t2< 50 ms). Associated embodiment involves real‐time precise measurements of a variety of health‐related physiological signals, ranging from wrist pulse, to finger motions, to vocalization and to facial expressions, with high sensitivity and accuracy. Studies on human subjects establish the clinical significance of these devices for future opportunities of health monitoring and intelligent control to predict and diagnose diseases.

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Antibacterial, antifungal, and anticancer potential of two-dimensional Ti3C2Tx MXene

Cited by 15 publications

References 15 publications

Mxene‐Based Supramolecular Composite Hydrogels for Antioxidant and Photothermal Antibacterial Activities

Mxene‐Based Supramolecular Composite Hydrogels for Antioxidant and Photothermal Antibacterial Activities

Cytocompatibility of Ti₃C₂T_x MXene with Red Blood Cells and Human Umbilical Vein Endothelial Cells and the Underlying Mechanisms

Smart MXene‐based bioelectronic devices as wearable health monitor for sensing human physiological signals

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Antibacterial, antifungal, and anticancer potential of two-dimensional Ti3C2Tx MXene

Cited by 15 publications

References 15 publications

Mxene‐Based Supramolecular Composite Hydrogels for Antioxidant and Photothermal Antibacterial Activities

Mxene‐Based Supramolecular Composite Hydrogels for Antioxidant and Photothermal Antibacterial Activities

Cytocompatibility of Ti3C2Tx MXene with Red Blood Cells and Human Umbilical Vein Endothelial Cells and the Underlying Mechanisms

Smart MXene‐based bioelectronic devices as wearable health monitor for sensing human physiological signals

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Product

Resources

About

Cytocompatibility of Ti₃C₂T_x MXene with Red Blood Cells and Human Umbilical Vein Endothelial Cells and the Underlying Mechanisms