Antibacterial, antifungal, cytotoxic, antioxidant and antidiabetic compounds from Nymphoides indica; the first comprehensive phytochemical and pharmacological study

Amin, Afaf Ali; Upadhyay, Aadesh; Zafar, Mehreen; Cos, Paul; Maes, Louis; Apers, Sandra; Exarchou, Vasiliki; Pieters, Luc

doi:10.1055/s-0034-1394772

Cited by 2 publications

(5 citation statements)

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“…wt. 492); HR-ESI-MS (positive ion mode) m / z 493.1346 [M + H] + , 1 H-NMR (CD 3 OD, 400 MHz): δ 7.63 (1H, d , J = 2.0 Hz, H-2′), 7.59 (1H, dd , J = 2.0, 8.4 Hz, H-6′), 7.31 (1H, d , J = 8.4 Hz, H-5′), 6.57 (1H, d , J = 2.0 Hz, H-8), 6.31 (1H, d , J = 2.0 Hz, H-6), 4.94 (1H, d , J = 7.2 Hz, H-1″), 3.4–3.8 (6H, m , protons of sugar party), 3.88 (3H, s , 3-OCH 3 ), 3.81 (3H, s , 7-OCH 3 ); 13 C-NMR (CD 3 OD, 100 MHz): 180.3 (C-4), 167.5 (C-7), 163.0 (C-5), 158.5 (C-9), 157.6 (C-2), 149.4 (C-4′), 148.4 (C-3′), 140.5 (C-3), 126.6 (C-1′), 122.1 (C-6′), 117.9 (C-5′), 117.4 (C-2′), 107.0 (C-10), 103.5 (C-1″), 99.2 (C-6), 93.3 (C-8), 78.6 (C-5″), 77.7 (C-3″), 75.0 (C-2″), 71.5 (C-4″), 62.3 (C-6″), 60.8 (3-OCH 3 ), 56.7 (7-OCH 3 ): Supporting information [ 20 , 47 ].…”

Section: Methodsmentioning

confidence: 99%

“…It has also been used for antipyretic, anticonvulsant, aphrodisiac, and antiproliferative purposes. A recent study has reported the pharmacological value of N. indica leaves and their phytochemicals due to its antimicrobial, antiprotozoal, anti-oxidant, and antidiabetic activities [ 20 ]. Another study demonstrated that the rhizomes of N. indica exhibit anticonvulsant activity [ 21 ].…”

Section: Introductionmentioning

confidence: 99%

“…Additionally, our previous studies on the biological activities of N. indica have demonstrated the inhibitory activity of whole-plant methanol extracts on melanin synthesis [ 22 ]. QDG, a major component of the N. indica leaves, is reported to have moderate anti-glycation and α-glucosidase inhibitory activities [ 20 ]; however, the cosmeceutical effects of QDG, isolated from N. indica , on skin cells have not yet been reported.…”

Section: Introductionmentioning

confidence: 99%

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Anti-Inflammatory and Skin-Moisturizing Effects of a Flavonoid Glycoside Extracted from the Aquatic Plant Nymphoides indica in Human Keratinocytes

Kim

Park

et al. 2018

Molecules

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Nymphoides indica, an aquatic plant, is used as folk medicine in some countries. Our previous study demonstrated that the methanol extract of N. indica inhibited the activity of tyrosinases, tyrosine related protein (TRP)1 and TRP2, and microphthalmia-associated transcription factor, as well as the activity of protein kinase A, by effectively inhibiting cyclic adenosine monophosphate. Although the biological activities of N. indica extract have been reported, there are no reports on the skin bioactivity of the main compound(s) on human keratinocytes. This study investigated the anti-inflammatory and moisturizing effects of quercetin 3,7-dimethyl ether 4′-glucoside (QDG) isolated from N. indica. In brief, ultraviolet B irradiated keratinocytes were pretreated with different concentrations of QDG, and the effects of QDG on various inflammatory markers were determined. QDG significantly inhibited inflammation-related cytokines and chemokines and enhanced the activation of skin barrier factors. Additionally, QDG also attenuated phosphorylation inhibition of the upstream cytokines and nuclear factor-κB expression. These results suggest that QDG isolated from N. indica may serve as a potential source of bioactive substances for chronic inflammatory skin diseases.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Anti-Inflammatory and Skin-Moisturizing Effects of a Flavonoid Glycoside Extracted from the Aquatic Plant Nymphoides indica in Human Keratinocytes

Kim

Park

et al. 2018

Molecules

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“…Earlier (Amin, et al, 2014) have reported that the order of Nymphoides indica leaves extract fractions antioxidant activity is ethyl acetate >90% methanol > chloroform with IC 50 values of 147 µg/mL, 211 µg/mL, and 380 µg/mL respectively. However, the plant leaves extract fractions antiglycation influence is in the following order n-butanol > chloroform > ethyl acetate >90% methanol fraction with IC 50 values of 32 µg/mL, 64 µg/mL, 69 µg/mL, and 86 µg/mL respectively [269] . [263] , besides, .…”

Section: Nymphoides Aquatic Plants Species Polyphenolic and Flavonoid...mentioning

confidence: 97%

“…However, earlier (Amine, et al, 2014) have reported the isolation of four flavonoids from various 90% methanolic, chloroform, ethyl acetate, and butanol Nymphoides indica leaves extracts. The methanolic extract has exhibited antimicrobial (antifungal and antibacterial) as well as cytotoxic influences at IC 50 values of 32 µg/mL and 38.9 µg/mL respectively, besides, nhexane extract has exhibited antibacterial as well as antifungal with IC 50 of 19.15 µg/mL [269] .…”

Section: Nymphoides Aquatic Plants Species Polyphenolic and Flavonoid...mentioning

confidence: 99%

Investigations on Kaempferol, Quercetin and Other Flavonoids in Aquatic Plants of Iraqi Marshlands-I

Al-Sa'idy,

Kamil Hamid

2023

Asian J Pharm Res Dev

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Aquatic plants are versatile source of phytochemicals that are of significant biological influences particularly, the flavonoids and their glycosidic derivatives distributed in different plant parts including fruits, seeds, leaves, flowers, stem, roots and rhizomes. Most of the reported biological influences are reported to be expressed by quercetin, kaempferol, isorhmnatin, and their glycosidic derivatives, particularly, rutin. In this survey, we summarized the reported flavonoids types, content and factors affecting their extracts contents of three aquatic plants Nuphar, Najas and Nymphoides detected in the Iraqi central marshlands, in provenance of Thi-Qar. Surveying the phytochemical investigations regarding Nuphar species of reported abundance of polyphenolic compounds content including identified and quantified phenolic acids, flavonoids like flavonols and flavonones, particularly, in their leaves. However, flavonoids/their derivatives types and quantities in various parts extracts are not reported to the extent of our knowledge although they are presumed to contribute to the reported biological influence of the plant on one hand. On the other hands, regarding Najas species, few reports have identified the existence of flavonoids as well as other phenolic compounds, although, total quantification to the phenolic compounds, flavonoids and tannins are reported rather than identifying the individual flavonoid in the plant extracts. Only single report demonstrates the total phenolic, flavonoids and tannin contents of ethyl acetate extract of Najar minor according to our survey. Regarding Nymphoides species, the extraction level flavonoids as lipophilic compounds as well as their much polar glycosidic derivatives is depending on the solvent polarities. In general, in most of Nymphoides species the ethanolic extract querectin, methylquercetin and kaempferol flvonoides/their derivatives are identified individual flavonoids/quantified to be more than one fold of that in the aqueous extracts. Finally, the manner/position of glycosylation as well as glycosides sugar resides acylation vary among the Nymphoides species. In general, single 3-O- or di 3,4’-O- glycosylation pattern is noticed in kaempferol, quercetin and isorhamnetin. The multiply diverse glycosylation, methylation as well as acylation pattern of Nymphoides species flavonoids may explains their identification in various plant part/extracts besides the variation in their biological activities potentials.

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Antibacterial, antifungal, cytotoxic, antioxidant and antidiabetic compounds from Nymphoides indica; the first comprehensive phytochemical and pharmacological study

Cited by 2 publications

References 0 publications

Anti-Inflammatory and Skin-Moisturizing Effects of a Flavonoid Glycoside Extracted from the Aquatic Plant Nymphoides indica in Human Keratinocytes

Anti-Inflammatory and Skin-Moisturizing Effects of a Flavonoid Glycoside Extracted from the Aquatic Plant Nymphoides indica in Human Keratinocytes

Investigations on Kaempferol, Quercetin and Other Flavonoids in Aquatic Plants of Iraqi Marshlands-I

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