Antibacterial effects of polymeric PolymP-n Active nanoparticles. An in vitro biofilm study

Sánchez, M.; Toledano-Osorio, Manuel; Bueno, João Romildo; Figuero, Elena; Toledano, Manuel; Medina-Castillo, Antonio L.; Osorio, Raquel; Herrera, David; Sanz, Mariano

doi:10.1016/j.dental.2018.11.015

Cited by 43 publications

(51 citation statements)

References 44 publications

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“…However, any foreign bodies inserted in oral cavity may provide new niches for the microorganisms, promoting biofilm accumulation. Such biofilm formation on dental materials appears to be like that around natural tooth, which potentially contributes to damage to the mineralized tissues or infections of the soft tissues [8,9]. Due to the great mechanical properties, biocompatibility, and excellent esthetic properties, zirconia has been widely applied for the fabrication of crowns, bridges, and ceramic posts in dentistry.…”

mentioning

confidence: 99%

Comparative Study on the Degree of Bacterial Biofilm Formation of Dental Bridges Made from Three Types of Materials

Bolat¹,

Bosinceanu²,

Sandu³

et al. 2019

Mat.Plast.

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The aim of this study was to compare the biofilm formation on three types of dental crown materials using adenosine triphosphate (ATP) driven bioluminescence as an innovative tool for the rapid chairside enumeration of oral bacteria and assessment of oral hygiene. The study group included 60 patients with fixed prosthodontics, made of three types of dental crown materials (BioHpp - Bredent, Ceramics - VITA VMK Master, and Zirconia - Vita In-Ceram) from which we have collected 60 specimen values using a luciferase-based assay system (system SURE II). The values of ATP were obtained with System SURE II device and statistically analyzed with Anova and Wilcoxon Test. The lowest value was shown for Zirconia, comparing with ceramics and BioHpp, but in time we have seen the increase of ATP for all three dental crown materials.

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mentioning

confidence: 99%

Comparative Study on the Degree of Bacterial Biofilm Formation of Dental Bridges Made from Three Types of Materials

Bolat¹,

Bosinceanu²,

Sandu³

et al. 2019

Mat.Plast.

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“…Studies in vitro showed that the mouthwash solution containing TiO 2 NPs showed superior antibacterial activity against oral pathogenic microorganisms [151]. Nanoparticles of Zn [152,153], Ag [2,154,155,156,157,158,159,160] synergistic with CHX [161,162] or doxycycline [163] showed significant antibacterial effect in an in vitro subgingival biofilm mode. Hexagonal form of boron nitride (hBN)—referred as “white graphite”—showed high antibiofilm activity on preformed biofilm and exhibited no cytotoxic effect on cells at the concentration range of 0.025–0.1 mg/mL [164].…”

Section: Antimicrobial Applications In Dentistrymentioning

confidence: 99%

Application of Antimicrobial Nanoparticles in Dentistry

2019

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Oral cavity incessantly encounters a plethora of microorganisms. Plaque biofilm—a major cause of caries, periodontitis and other dental diseases—is a complex community of bacteria or fungi that causes infection by protecting pathogenic microorganisms from external drug agents and escaping the host defense mechanisms. Antimicrobial nanoparticles are promising because of several advantages such as ultra-small sizes, large surface-area-to-mass ratio and special physical and chemical properties. To better summarize explorations of antimicrobial nanoparticles and provide directions for future studies, we present the following critical review. The keywords “nanoparticle,” “anti-infective or antibacterial or antimicrobial” and “dentistry” were retrieved from Pubmed, Scopus, Embase and Web of Science databases in the last five years. A total of 172 articles met the requirements were included and discussed in this review. The results show that superior antibacterial properties of nanoparticle biomaterials bring broad prospects in the oral field. This review presents the development, applications and underneath mechanisms of antibacterial nanoparticles in dentistry including restorative dentistry, endodontics, implantology, orthodontics, dental prostheses and periodontal field.

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“…Due to the surface chemistry of the nanoparticles, containing functional groups with sequences of anionic carboxylate (i.e. COO − ), it was possible to dope metal cations (in this case calcium, zinc and silver) and antibiotics (doxycycline), with potential antibacterial activity [73]. A multispecies periodontal biofilm was developed by using Streptococcus oralis ( S. oralis ), Actinomyces naeslundii ( A. naeslundii ), Veillonella parvula ( V. parvula ), Fusobacterium nucleatum ( F. nucleatum ), P. gingivalis and A. actinomycetemcomitans to investigate the antibacterial properties of polymeric PolymP-n active nanoparticles doped with different substances: zinc, calcium, silver and doxycycline [73].…”

Section: Polymeric Materials As Drug Carrier For Combating Periodomentioning

confidence: 99%

“…COO − ), it was possible to dope metal cations (in this case calcium, zinc and silver) and antibiotics (doxycycline), with potential antibacterial activity [73]. A multispecies periodontal biofilm was developed by using Streptococcus oralis ( S. oralis ), Actinomyces naeslundii ( A. naeslundii ), Veillonella parvula ( V. parvula ), Fusobacterium nucleatum ( F. nucleatum ), P. gingivalis and A. actinomycetemcomitans to investigate the antibacterial properties of polymeric PolymP-n active nanoparticles doped with different substances: zinc, calcium, silver and doxycycline [73]. A similar biofilm formation was observed, although reductions in bacterial viability were detected in biofilms in contact with the different nanoparticles, and were more pronounced with silver and doxycycline nanoparticles.…”

Section: Polymeric Materials As Drug Carrier For Combating Periodomentioning

confidence: 99%

“…A similar biofilm formation was observed, although reductions in bacterial viability were detected in biofilms in contact with the different nanoparticles, and were more pronounced with silver and doxycycline nanoparticles. PolymP-n nanoparticles with doxycycline resulted in unstructured biofilm formation and significantly lower colony units of the six species, compared with the other specimens and controls [73]. However, with the emergence and increase of microbial resistance to antibiotics, further studies should investigate not only antibiotic-free delivery systems but also antimicrobial peptides (AMPs) for treating periodontal infections.…”

Section: Polymeric Materials As Drug Carrier For Combating Periodomentioning

confidence: 99%

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Novel Bioactive and Therapeutic Dental Polymeric Materials to Inhibit Periodontal Pathogens and Biofilms

Chi

et al. 2019

IJMS

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Periodontitis is a common infectious disease characterized by loss of tooth-supporting structures, which eventually leads to tooth loss. The heavy burden of periodontal disease and its negative consequence on the patient’s quality of life indicate a strong need for developing effective therapies. According to the World Health Organization, 10–15% of the global population suffers from severe periodontitis. Advances in understanding the etiology, epidemiology and microbiology of periodontal pocket flora have called for antibacterial therapeutic strategies for periodontitis treatment. Currently, antimicrobial strategies combining with polymer science have attracted tremendous interest in the last decade. This review focuses on the state of the art of antibacterial polymer application against periodontal pathogens and biofilms. The first part focuses on the different polymeric materials serving as antibacterial agents, drug carriers and periodontal barrier membranes to inhibit periodontal pathogens. The second part reviews cutting-edge research on the synthesis and evaluation of a new generation of bioactive dental polymers for Class-V restorations with therapeutic effects. They possess antibacterial, acid-reduction, protein-repellent, and remineralization capabilities. In addition, the antibacterial photodynamic therapy with polymeric materials against periodontal pathogens and biofilms is also briefly described in the third part. These novel bioactive and therapeutic polymeric materials and treatment methods have great potential to inhibit periodontitis and protect tooth structures.

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Antibacterial effects of polymeric PolymP-n Active nanoparticles. An in vitro biofilm study

Cited by 43 publications

References 44 publications

Comparative Study on the Degree of Bacterial Biofilm Formation of Dental Bridges Made from Three Types of Materials

Comparative Study on the Degree of Bacterial Biofilm Formation of Dental Bridges Made from Three Types of Materials

Application of Antimicrobial Nanoparticles in Dentistry

Novel Bioactive and Therapeutic Dental Polymeric Materials to Inhibit Periodontal Pathogens and Biofilms

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