Antibacterial polysaccharide-based hydrogel dressing containing plant essential oil for burn wound healing

Wang, Huanhuan; Liu, Yang; Cai, Kun; Zhang, Bin; Tang, Shijie; Zhang, Wancong; Liu, Wenhua

doi:10.1093/burnst/tkab041

Cited by 58 publications

(31 citation statements)

References 50 publications

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“…VEGF presence was observed in high levels during all the stages of burn injury 42 .Potentialize vascular activity as seen after increase in VEGF levels on groups that received McLTP1 may be associated with faster healing. Other findings of literature also showed rapidly healing after increasing VEGF expression 49,50,51 .…”

Section: Discussionmentioning

confidence: 54%

McLTP1, a lipid transfer protein isolated from noni seeds induces effective healing of superficial burns

Kurita

Rangel

Rabelo

et al. 2023

Preprint

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Burns are health problems that overwhelm the Unified Health System (SUS) in Brazil. Despite the new therapeutic strategies, the costs of treating burns ate still quite high, and there are no effective alternatives for healing the skin. The use of plants with therapeutic potential is popularly used, due to its low cost, easy access and great Brazilian biodiversity. McLTP1, a lipid transfer protein isolated from Morinda citrifollia (noni) seeds, has shown antinociceptive, anti-inflammatory, antibacterial and antioxidative effects. Therefore, the aim of this study was to investigate the effect of McLTP1 on the healing of superficial burns in mice. The study was approved by CEUA NPDM UFC (protocol: 021706190). The burn was induced by direct contact with a square stainless-steel plate (1.5 cm2). The animals were divided into five experimental groups (n=6-7/grupo) and treated daily with 0.9% NaCl saline solution (Sham), or with topical treatment performed with dermatological creams: Silver sulfadiazine 1% (Sulfa 1%), lanette cream (Vehicle), cream lanette containing 0.25% and 0.5% of McLTP1. The animals were euthanized after 14 days. McLTP1 promoted total wound closure after 2 weeks of treatment, reduced histopathological scores at 3rd day, as well as induced the formation of a thicker epithelium and collagens synthesis on 14th day, modulated inflammation by reducing MPO activity, TNF-a, IL-1B and IL-6 levels and increasing IL-10 after 3 days of burn, modulated VEGF production at three times analyzed in this study, increased TGF-B and immunostaining for FGF after 7 days, reduced immunostaining for TNF-a on the 3rd day and exerted an antioxidant function by reducing MDA and nitrite and increasing GSH at day 3. In short, McLTP1 showed an important healing action in this burn model, showing additional anti-inflammatory and antioxidant effects.

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Section: Discussionmentioning

confidence: 54%

McLTP1, a lipid transfer protein isolated from noni seeds induces effective healing of superficial burns

Kurita

Rangel

Rabelo

et al. 2023

Preprint

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“…Porous polysaccharide-based hydrogels can be cross-linked with active substances, such as oils extracted from aromatic plants, including terpenoids and terpenes. Essential oils are active against Gram-positive and Gram-negative bacteria and have antioxidative capacities [ 48 ].…”

Section: Antimicrobial Activitymentioning

confidence: 99%

Hydrogels in Burn Wound Management—A Review

Surowiecka¹,

Strużyna

Winiarska³

et al. 2022

Gels

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Inert hydrogels are of a great importance in burn first aid. Hydrogel dressings may be an alternative to cooling burn wounds with streaming water, especially in cases of mass casualty events, lack of clean water, hypothermia, or large extent of burns. Hydrogels that contain mostly water evacuate the heat cumulating in the skin by evaporation. They not only cool the burn wound, but also reduce pain and protect the wound area from contamination and further injuries. Hydrogels are ideally used during the first hours after injury, but as they do not have antimicrobial properties per se, they might not prevent wound infection. The hydrogel matrix enables incorporating active substances into the dressing. The active forms may contain ammonium salts, nanocrystal silver, zinc, growth factor, cytokines, or cells, as well as natural agents, such as honey or herbs. Active dressings may have antimicrobial activity or stimulate wound healing. Numerous experiments on animal models proved their safety and efficiency. Hydrogels are a new dressing type that are still in development.

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“…In this study, the appearance of the wounds in the four groups of rats was constantly evaluated for 8 days to assess the progress of wound healing. Photographs of the wound may be a crucial indicator of how well the wound is healing [ 50 , 51 ]. By decreasing downtime and accelerating re-epithelialization, MLWSP gel seems to be perfect for wound healing.…”

Section: Discussionmentioning

confidence: 99%

Polysaccharides from South Tunisian Moringa alterniflora Leaves: Characterization, Cytotoxicity, Antioxidant Activity, and Laser Burn Wound Healing in Rats

Aydi

Khadher

et al. 2023

Plants

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Phytochemical properties have recently increased the popularity of plant polysaccharides as wound dressing materials. This work aims at studying the structural characteristics of polysaccharides extracted from Moringa leaves (Moringa Leaves Water Soluble Polysaccharide: MLWSP), and its antioxidant activities, cytotoxic effects, and laser burn wound healing effects in rats. This MLWSP was structurally characterized. Results showed 175.21 KDa and 18.6%, respectively, for the molecular weight and the yield of the novel extracted polysaccharide. It is a hetero-polysaccharide containing arabinose, rhamnose, and galactose. XRD suggested a semi-crystalline structure of the studied polymer and FT-IR results revealed a typical polysaccharide structure. It is composed of 50 to 500 µm rocky-shaped units with rough surfaces and it was found to inhibit the proliferation of the human colon (HCT-116) (IC50 = 36 ± 2.5 µg/mL), breast (MCF-7) (IC50 = 48 ± 3.2), and ovary cancers (IC50 = 24 ± 8.1). The MLWSP showed significant antioxidant effects compared to Trolox (CI50 = 0.001 mg/g). Moreover, promising wound healing results were displayed. The effect of MLWSP hydrogel application on laser burn injuries stimulated wound contraction, re-epithelization, and remodeling phases 8 days after treatment. The wound healing potential of MLWSP may be due to its significant antioxidant activity and/or the huge amount of monosaccharide molecules.

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Antibacterial polysaccharide-based hydrogel dressing containing plant essential oil for burn wound healing

Cited by 58 publications

References 50 publications

McLTP1, a lipid transfer protein isolated from noni seeds induces effective healing of superficial burns

McLTP1, a lipid transfer protein isolated from noni seeds induces effective healing of superficial burns

Hydrogels in Burn Wound Management—A Review

Polysaccharides from South Tunisian Moringa alterniflora Leaves: Characterization, Cytotoxicity, Antioxidant Activity, and Laser Burn Wound Healing in Rats

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