Antibacterial properties of mesoporous copper-doped silica xerogels

Abstract

Mesoporous copper-doped silica xerogels (m-SXCu) with antibacterial properties were synthesized by a sol-gel process, and the morphology, structure and composition of m-SXCu were characterized. The results show that m-SXCu5 with a high surface area of 463.1 m(2) g(-1) have a mesoporous structure with a pore size of about 2 nm. The addition of Cu from 1 to 5 wt% to m-SXCu had a slight effect on the surface area and a not-so-obvious effect on the mesoporous size of m-SXCu. Cu ions can be released from m-SXCu into the simulated body fluid, and the release rate depends significantly on their number. The m-SXCu possessed good antibacterial activity against both E. coli and S. aureus, in which the antibacterial rate reached 99% for m-SXCu5 at 1 h while reaching 99% for all m-SXCu at 24 h. The antibacterial rate was improved with the increase of the amount of Cu, indicating that addition of Cu ions to m-SX enhanced its antibacterial activity.

Degradability, bioactivity, and osteogenesis of biocomposite scaffolds of lithium-containing mesoporous bioglass and mPEG-PLGA-b-PLL copolymer

“…20 Biocomposites containing BG and polymers have attracted increasing attention as promising biomaterials for bone tissue regeneration. 21,22 In this study, Li-MBG was incorporated into copolymer of mPEG-PLGA-b-PLL to form biocomposite scaffolds by solvent casting and particulate leaching method.…”

Sustained release of VH and rhBMP-2 from nanoporous magnesium–zinc–silicon xerogels for osteomyelitis treatment and bone repair

“…[4][5][6] The non-ionic block copolymer EO 20 PO 70 EO 20 (Pluronic P123, molecular weight =5,800, Sigma-Aldrich, St Louis, MO, USA) was used as the template agent. In brief, 4.8 g of P123 was dissolved in 480 mL of 0.1 M HCl aqueous solution at 50°C to obtain a white emulsion.…”

“…[1][2][3][4][5][6] To date, some studies have reported the design of drug-delivery systems based on the nanoporous materials for loading therapeutic molecules, such as chemical drugs, peptides, and proteins. 7,8 As an effective vector-delivering therapeutic molecules, the nanoporous materials with the pore size of a few nanometers have high capacity to encapsulate large amounts of drugs/biomolecules.…”

Combination of positive charges and honeycomb pores to promote MC3T3-E1 cell behaviour

“…15,16 PLLA, an aliphatic polyester and also a biodegradable polymer, has been widely studied due to its biocompatibility, biodegradability, and low immunogenicity to explore advanced tissue-engineering applications. [17][18][19][20][21][22][23] Despite the aforementioned advantages of PLLA, it also possesses some signicant drawbacks, such as low hydrophilicity, poor cell affinity, difficulty in controlling the degradation, and the generation of local acidic conditions during degradation. 24,25 To improve the functions of PLLA for biomedical applications, modications with other molecules including polyethylene glycol (PEG), polypyrrole, and poly(L-lysine) (PLL) covalently or noncovalently, have been investigated.…”