Antibiofilm activity of klebocin crude extract against some species of Enterobacteriaceae

Khalaf, Zainab Zamel; Hussein, Alyaa

doi:10.24996/ijs.2018.59.4a.7

Cited by 3 publications

(1 citation statement)

References 31 publications

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“…Then, the plate was incubated at 37ºC for 72 hrs. After that, all the remaining steps of the reference method were followed [24] Phytochemical screening by high performance liquid chromatography (HPLC)…”

Section: Antibiofilmmentioning

confidence: 99%

The Efficiency of Apple Vinegar as A Solvent in Comparison to Water and Ethanol for The Extraction of Some Plants used Against Candida Spp. Biofilm Formation

Mohammed

Jabbar

Nayyef

et al. 2021

eijs

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Apple vinegar has many uses that include burn and wound healing and as an antimicrobial agent against different microorganisms, but not as a solvent. Therefore, this study aimed to use commercial apple vinegar as solvent to the plants of roselle (Hibiscus sabdariffa), green tea (Camellia sinensis), and clove (Syzygium aromaticum). The effects of apple-vinegar extracts of these plants were compared with those of aqueous and ethanolic extracts against biofilm formation by Candida genus. Clove vinegar extract demonstrated antibiofilm activity against C. albicans, alone (2.4907± 0.382) or in combination with the antifungal agents fluconazole (1.689±0.33), nystatine (1.941±0.64), and clotrimazole (2.0353±0.71819). These plant extracts possessed a variable number of antimicrobial compounds, as tested by the HLPC technique. Therefore, apple vinegar was the most efficient solvent, in comparison with the other solvents used in this study, to obtain some phytochemical compounds from the tested plants that have antibiofilm activity against C. albicans.

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Section: Antibiofilmmentioning

confidence: 99%

The Efficiency of Apple Vinegar as A Solvent in Comparison to Water and Ethanol for The Extraction of Some Plants used Against Candida Spp. Biofilm Formation

Mohammed

Jabbar

Nayyef

et al. 2021

eijs

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Bacteriocins: Potential for Human Health

Huang

Teng

Liu

et al. 2021

Oxidative Medicine and Cellular Longevity

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Due to the challenges of antibiotic resistance to global health, bacteriocins as antimicrobial compounds have received more and more attention. Bacteriocins are biosynthesized by various microbes and are predominantly used as food preservatives to control foodborne pathogens. Now, increasing researches have focused on bacteriocins as potential clinical antimicrobials or immune-modulating agents to fight against the global threat to human health. Given the broad- or narrow-spectrum antimicrobial activity, bacteriocins have been reported to inhibit a wide range of clinically pathogenic and multidrug-resistant bacteria, thus preventing the infections caused by these bacteria in the human body. Otherwise, some bacteriocins also show anticancer, anti-inflammatory, and immune-modulatory activities. Because of the safety and being not easy to cause drug resistance, some bacteriocins appear to have better efficacy and application prospects than existing therapeutic agents do. In this review, we highlight the potential therapeutic activities of bacteriocins and suggest opportunities for their application.

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Antibacterial activity of klebocin against methicillin resistance Staphylococcus aureus

Hussein¹,

Khalaf²

2022

Biomedicine

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Introduction and Aim: Bacteriocins are antimicrobial peptides that have bactericidal and/or bacteriostatic activity against other bacteria. The aim of this study was to assess the antibacterial efficiency of Klebocin a K. pneumoniae bacteriocin, against biofilm formation by clinical isolates of methicillin resistant Staphylococcus aureus MRSA. Materials and Methods: S. aureus isolated from clinical samples was identified according to vitek 2 system Antibiotic susceptibility test was performed according to disc diffusion method. Vitek 2 compact system was also used to detect MRSA strains. Agar well diffusion method was used to evaluate the antibacterial activity of klebocin from K. pneumoniae towards 11 strains of S. aureus by the microtiter plate method throughout the initial and final steps of biofilm development. Results: Our finding shown that crude extract of klebocin was active against all the tested pre-formed biofilm of S.aureus isolates and the percentage of inhibition ranging from 78.9-88.5%. Also the results of the current study demonstrated that all matured bacterial biofilm was inhibited in at a percentage ranging from 41.2% - 91.2%. Conclusion: This finding proved that klebocin had antibacterial activity against planktonic cells of S.aureus in addition to antibiofilm activity against premature and mature biofilm of MRSA. Also klebocin had broad spectrum activity effecting Gram +ve bacteria and its biofilm production.

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Antibiofilm activity of klebocin crude extract against some species of Enterobacteriaceae

Cited by 3 publications

References 31 publications

The Efficiency of Apple Vinegar as A Solvent in Comparison to Water and Ethanol for The Extraction of Some Plants used Against Candida Spp. Biofilm Formation

The Efficiency of Apple Vinegar as A Solvent in Comparison to Water and Ethanol for The Extraction of Some Plants used Against Candida Spp. Biofilm Formation

Bacteriocins: Potential for Human Health

Antibacterial activity of klebocin against methicillin resistance Staphylococcus aureus

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