Antibiofilm activity of nanoemulsions of Cymbopogon flexuosus against rapidly growing mycobacteria

Rossi, Grazielle Guidolin; Guterres, Kevim Bordignon; Bonez, Pauline Cordenonsi; Gündel, Samanta da Silva; Aggertt, Vanessa Albertina; Siqueira, Fallon S.; Ourique, Aline Ferreira; Wagnerd, Roger; Klein, Bruna; Santos, Roberto Christ Vianna; Campos, Marli Matiko Anraku de

doi:10.1016/j.micpath.2017.11.002

Cited by 39 publications

(34 citation statements)

References 48 publications

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“…The pH was determined directly in the formulations using a potentiometer (DM‐22, Digimed ® ) previously calibrated with standard solution. All readings were performed in triplicate and the results expressed as mean ± standard deviation (Rossi et al, ).…”

Section: Methodsmentioning

confidence: 99%

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Low‐dose curcumin‐loaded Eudragit L‐100‐nanocapsules in the diet of dairy sheep increases antioxidant levels and reduces lipid peroxidation in milk

et al. 2019

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The main objective of this study was to evaluate whether the addition of curcumin‐loaded nanocapsules (prepared and characterized) in the diets of dairy sheep improved milk quality. The nanocapsules were prepared using two polymers: poly‐ε‐caprolactone (PCL) and Eudragit L‐100. The nanocapsules contained 0.25 mg/ml (Nano‐Eudragit L‐100) and 2 mg/ml (Nano‐PCL) of curcumin. Dairy sheep were divided into four groups: A (control), B (30 mg free curcumin/kg concentrate), C (3 mg Nano‐PCL/kg concentrate), and D (3 mg Nano‐Eudragit/kg concentrate). We observed that the number of total leukocytes and serum globulin levels were lower in Group D than in the control (Group A) (p < 0.05). Antioxidant capacity against peroxyl radicals (ACAP) and catalase enzymes was elevated in Group D, with consequently reduced lipid peroxidation (LPO; p < 0.05). In milk, there were no differences in production and composition between groups during the experimental period (p > 0.05); however, ACAP increased and LPO decreased in milk. Practical applications Curcumin is a functional molecule with potent antioxidant, anti‐inflammatory, and antimicrobial actions, used frequently and with medical indications in human food. Free curcumin in sheep diets improves milk quality and increases its shelf life. This study showed that curcumin nanocapsules produced from the Eudragit L‐100 polymer potentiated the anti‐inflammatory and antioxidant actions of dairy sheep when used in the diet daily, at doses 10 times lower than that of free curcumin. These positive effects were reflected in higher total antioxidant capacity and lower lipid peroxidation in milk in sheep‐fed curcumin‐loaded Eudragit L‐100 nanocapsules, generating desirable milk properties. In practice, the use of nanotechnology enhances the beneficial effects of curcumin in milk, possibly creating a nutraceutical food desirable to consumers.

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Section: Methodsmentioning

confidence: 99%

“…After preparation, the formulations were characterized according to medium particle size, polydispersity index, zeta potential, pH, active content, encapsulation efficiency, and morphology (Coradini et al, 2014;Gündel, Velho, et al, 2018;Rossi et al, 2017;Zanotto-Filho et al, 2013).…”

Section: Nanocapsule Characterizationmentioning

confidence: 99%

Low‐dose curcumin‐loaded Eudragit L‐100‐nanocapsules in the diet of dairy sheep increases antioxidant levels and reduces lipid peroxidation in milk

et al. 2019

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“…Biological assay of C. martinii extracts revealed a potential of this species as a strong antioxidant (Andrade et al 2014a), and anti-inflammatory (Andrade et al 2014b). C. flexuosus showed positive activities as antibiofilm against rapidly growing mycobacteria (Rossi et al 2017), mosquito repellent (Carreño Otero et al 2018), and anti-inflammatory (Han and Parker 2017). C. schoenanthus exhibited positive anticancer activity by promoting melanogenesis in B16 melanoma cells and human epidermal melanocytes (Villareal et al 2017) and positive antibacterial activities against Escherichia coli, Staphylococcus aureus, methicillin-sensitive (MSSA) and Klebsiella pneumoniae ( Hashim et al 2017).…”

Section: Introductionmentioning

confidence: 99%

The phytochemistry of Cymbopogon winterianus essential oil from Lombok Island, Indonesia and its antifungal activity against phytopathogenic fungi

et al. 2018

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Andila PS, Hendra IPA, Wardani PK, Tirta IG, Sutomo, Fardenan D. 2018. The phytochemistry of Cymbopogon winterianus essential oil from Lombok Island, Indonesia and its antifungal activity against phytopathogenic fungi. Nusantara Bioscience 10: 232-239. Cymbopogon winterianus Jowitt ex Bor [Sereh Wangi] is a plant producing essential oil that has been extensively used in perfumery, mosquito repellent, medicinal, and cosmetic industry. In Indonesia, the accession of C. winterianus plant had been collected from natural forest in Sembalun, Lombok, West Nusa Tenggara (NTB) Province. However, the phytochemical properties and its biological potential of this accession have never been reported. The aim of this study was to determine the phytochemical content of essential oil of C. winterianus from Lombok and to explore its potential as a bioantifungal against several phytopathogen fungi. The essential oils were extracted from fresh stem and leaf of C. winterianus by hydrodistillation. The chemical composition of them was determined by chromatography-mass spectrometry (GC-MS). A total of 26 and 20 compounds were obtained from the stem and leaf oil with the dominant compounds of essential oil in stem were Torreyol (17.89%), Oxirane, octyl- (15.84%), (-)-Isopulegol (14.44%), Isopulegol 2 (12.18%), and Geranyl Acetate (5.89%) while in leaf were (-)-Isopulegol (22.69%), Oxirane, octyl- (16.64%), Cyclohexanol, 5-methyl-2-(1-methylethenyl)- (14.21%), "KW3 AUS Epiglobulol” (9.47%), and Cyclohexene, 1-methyl-4-(1-methylethenyl)- (7.14%). The presence of these contents as dominant chemical compounds in S. winterianus was reported for the first time. The highest content of oils was identified as monoterpene (38.01% and 45.78% in stem and leaf oil) and sesquiterpene ( 27.67% and 17.78 % in stem and Leaf oil). The biological study showed that leaf essential of C. winterianus expressed positive antifungal activity against Fusarium solani, Aspergillus niger, dan Cladosporium sp.

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“…Recent decades mark an exponential upsurge in establishing the bioactivities of lemongrass extract and essential oil. Feeding studies establish that LEO has antimicrobial, anticancer, anti-amoebic, anti-diarrhoeal, anti-filarial, antitussive, antiseptic, larvicidal, insecticidal, miticidal, ovicidal, acaricidal, analgesic, anesthetic, anti-inflammatory, antioxidant, antinociceptive, antihypertensive, anti-obesity, anxiolytic, and antimutagenicity potential, cardio-protective, anti-rheumatic, and hematological properties [7,[17][18][19][20][21][22][23][24][25][26][27][28][29]. These bioactivities are the direct product of the individual and synergistic effect of different major and minor LEO components [11].…”

Section: Leo Therapeuticsmentioning

confidence: 99%

Lemongrass Essential Oil Components with Antimicrobial and Anticancer Activities

Mukarram¹,

Choudhary²,

Khan³

et al. 2021

Preprint

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The prominent cultivation of lemongrass relies on the pharmacological incentives of its essential oil. The lemongrass essential oil (LEO) has a significant amount of citral (mixture of geranial and neral), isoneral, isogeranial, geraniol, geranyl acetate, citronellal, citronellol, germacrene-D, and elemol in addition to numerous other bioactive compounds. These components confer various medicinal activities to LEO including antifungal, antibacterial, antiviral, anticancer, and antioxidant properties. These attributes are commercially exploited in pharmaceutical, cosmetics, and food preservations industries. Furthermore, the employment of LEO in the treatment of cancer opens a new vista in the field of therapeutics. Although different LEO components have shown promising anticancer activities in vitro, these effects have not been assessed yet in humans. Further studies on the anticancer mechanisms exerted by lemongrass components are required. The present review intends to provide a timely discussion on the relevance of lemongrass extracts in cancer and health treatment, and in food industry applications.

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Antibiofilm activity of nanoemulsions of Cymbopogon flexuosus against rapidly growing mycobacteria

Cited by 39 publications

References 48 publications

Low‐dose curcumin‐loaded Eudragit L‐100‐nanocapsules in the diet of dairy sheep increases antioxidant levels and reduces lipid peroxidation in milk

Low‐dose curcumin‐loaded Eudragit L‐100‐nanocapsules in the diet of dairy sheep increases antioxidant levels and reduces lipid peroxidation in milk

The phytochemistry of Cymbopogon winterianus essential oil from Lombok Island, Indonesia and its antifungal activity against phytopathogenic fungi

Lemongrass Essential Oil Components with Antimicrobial and Anticancer Activities

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