Antibiotic resistance in Vibrio cholerae El Tor strains isolated during cholera complications in Siberia and the Far East of Russia

Гладких, А. С.; Feranchuk, Sergey; Ponomareva, A. S.; Bochalgin, N. O.; Mironova, L. V.

doi:10.1016/j.meegid.2019.104096

Cited by 22 publications

(6 citation statements)

References 55 publications

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“…This was also supported by a study that reported 100% resistance towards penicillins, more than 80% towards first and second-generation cephalosporins, and 20% towards fluoroquinolones and macrolides [23]. On contrary, Vibrio species showed 90% susceptibility to fluoroquinolones and 80% susceptibility to carbapenems consistent with findings in China [24] but resistance patterns were similar against penicillins, erythromycin, and clindamycin as in other isolates in our study. The resistance in both Enterococci and Shigella was 100% towards erythromycin and ceftriaxone, followed by 90% against ampicillin and cefoxitin concurrent with other studies [25].…”

Section: Discussionsupporting

confidence: 92%

Prevalence of Bacteria and Antimicrobial Resistance Genes in Hospital Water and Surfaces

Aleem¹,

Azeem²,

Rahmatullah³

et al. 2021

Cureus

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Antimicrobial resistance (AMR) has become a worldwide environmental and public health problem, causing more than 250,000 deaths per year. Unregulated usage, unsafe hospital practices, and misuse in veterinary contribute to the development of multidrug resistance in various bacteria. Hospital water was hypothesized to be a hotspot for AMR transmission because of (1) increased exposure to antibiotic load, (2) poor drainage and sanitation system, (3) interaction between environmental and clinical microbes. The purpose of the research was to assess the biodiversity and AMR in hospital tap waters. MethodologyIn this study, the microflora of the hospital tap water and hospital surfaces was observed by obtaining water samples from the intensive care unit (ICU), surgical wards, and washrooms. These were processed through membrane filtration and spread on seven different

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Section: Discussionsupporting

confidence: 92%

Prevalence of Bacteria and Antimicrobial Resistance Genes in Hospital Water and Surfaces

Aleem¹,

Azeem²,

Rahmatullah³

et al. 2021

Cureus

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“…Salienta-se também a importância dos elementos conjugativos integrativos (ICEs, do inglês, "Integrative Conjugative Elements"), como os da família STX/R391. Esse ICE é encontrado em diversos gêneros bacterianos, inclusive Vibrio, conferindo resistência a antimicrobianos e a metais pesados, além de codificar genes de virulência (Gladkikh et al, 2020).…”

Section: Características Gerais De Vibrio Sppunclassified

“…Ademais, um estudo realizado na Sibéria demonstrou que estirpes de V. cholerae responsáveis por um surto de cólera na região apresentavam resistência fenotípica a até nove antimicrobianos (incluindo aminoglicosídeos, tetraciclinas, sulfonamidas, cloranfenicol, quinolonas e nitrofuranos), apresentando também uma série de genes de resistência (Gladkikh et al, 2020).…”

Section: Susceptibilidade Aos Antimicrobianos Em Vibrio Sppunclassified

O gênero Vibrio: conceitos atuais e novas perspectivas

Canellas,

Lopes,

Oliveira

et al. 2023

Rev. Biol.

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O gênero Vibrio é um grupo bacteriano extremamente versátil. Seus membros são amplamente distribuídos em ambientes aquáticos, sendo a maioria não patogênica. Contudo, algumas espécies são patógenos de humanos e animais, causando impactos significativos na saúde pública e economia. Recentemente, o estudo dessas bactérias vem ganhando mais destaque, constituindo a área central de pesquisas em diversas áreas da Microbiologia. Nesse sentido, estudos buscam investigar sua patogenicidade, perfil de susceptibilidade aos antimicrobianos, potencialidades biotecnológicas e suas interações com fatores ambientais, sendo este último de notável relevância no contexto das mudanças climáticas. Assim, o presente trabalho objetiva fornecer uma revisão atualizada a respeito do gênero Vibrio, evidenciando sua relevância no contexto ambiental e clínico e indicando potenciais áreas para futuros estudos.

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“…Antibiotic therapy is crucial for the treatment of cholera, as it abates the period of diarrhea, the amount of rehydration fluids, and the density of vibrios excreted in the stools (World Health Organization [WHO], 2019). Over the years, the rapid emergence of extensive drug-resistant (XDR) and multidrug-resistant (MDR) V. cholerae strains possess a great public health threat, owing to their association with treatment failure and potential dissemination of resistance among other pathogens through mobile genetic elements (MGEs) (Chowdhury et al, 2016;Clemens et al, 2017;Verma et al, 2019;Gladkikh et al, 2020). The above caveats compel the need for developing novel strategies to thwart V. cholerae infection.…”

Section: Introductionmentioning

confidence: 99%

Exploration of Anti-infectives From Mangrove-Derived Micromonospora sp. RMA46 to Combat Vibrio cholerae Pathogenesis

et al. 2020

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Vibrio cholerae, the etiological agent of cholera, employs quorum sensing (QS) pathways to control the expression of virulence factors, including the production of cholera toxin and biofilm formation. Acquired antibiotic resistance in V. cholerae draws attention to the development of novel therapeutics that counteract virulence, rather than the viability of the pathogen. In this context, we explored the anti-infective potential of rare marine Actinobacteria (RMA) from a mangrove ecosystem. Here, we report the effects of Micromonospora sp. RMA46 against V. cholerae in vitro. The RMA46 organic extract was non-bactericidal to V. cholerae cells and non-cytotoxic to macrophage RAW264.7 cell lines. RMA46 inhibited the formation of V. cholerae biofilms and downregulated the QS global switches LuxO and HapR, as well as other virulence genes including ct, tcp, and hapA. In silico molecular docking simulation of RMA46 ethyl acetate extract with LuxO and HapR revealed that 2-methoxy-4-vinylphenol and hexahydro-3-(phenylmethyl)-pyrrolo[1,2-a]pyrazine-1,4-dione could interact with the active sites of LuxO and HapR and potentially inhibit them. This study highlights Micromonospora sp. RMA46 as a potential source of anti-infectives against V. cholerae.

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Antibiotic resistance in Vibrio cholerae El Tor strains isolated during cholera complications in Siberia and the Far East of Russia

Cited by 22 publications

References 55 publications

Prevalence of Bacteria and Antimicrobial Resistance Genes in Hospital Water and Surfaces

Prevalence of Bacteria and Antimicrobial Resistance Genes in Hospital Water and Surfaces

O gênero Vibrio: conceitos atuais e novas perspectivas

Exploration of Anti-infectives From Mangrove-Derived Micromonospora sp. RMA46 to Combat Vibrio cholerae Pathogenesis

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