Antibiotic Resistance Related to Biofilm Formation in Klebsiella pneumoniae

Abstract

The Gram-negative opportunistic pathogen, Klebsiella pneumoniae, is responsible for causing a spectrum of community-acquired and nosocomial infections and typically infects patients with indwelling medical devices, especially urinary catheters, on which this microorganism is able to grow as a biofilm. The increasingly frequent acquisition of antibiotic resistance by K. pneumoniae strains has given rise to a global spread of this multidrug-resistant pathogen, mostly at the hospital level. This scenario is exacerbated when it is noted that intrinsic resistance to antimicrobial agents dramatically increases when K. pneumoniae strains grow as a biofilm. This review will summarize the findings about the antibiotic resistance related to biofilm formation in K. pneumoniae.

Antibiotic Resistance and Biofilm Formation Among Nosocomial Pathogens in a Tertiary Care Hospital

“…The most common healthcare-associated infections caused by this strain involves the urinary tract infection, wound infections, lungs infection, colonisation of intravascular devices, surgical site and soft tissues infection and subsequent bacteraemia. (13) In the prevailing study, it was found that K. pneumoniae was maximum isolated from the endotracheal tube tips and the tracheostomy tube tips followed by A. baumannii and P. aeruginosa. Since these organisms are highly linked as oral pathogens their association with biofilm formation on these tips can be a reason behind their high prevalence.…”

Biofilms associated with bowel necrosis: A newly recognised phenomenon in infants

“…In any case, other mechanisms are involved, and further studies are required to elaborate on new concepts in the preventive measures against nosocomial K. pneumoniae infections in the future. [11] In chronic surface wounds with biofilms, the latter can be eradicated with topical bioflammacide therapy; this would not be an option for gastrointestinal disease. [12] …”

Use of Turmeric (Curcuma longa L.) Essential Oil Added to an Egg White Protein Powder-Based Film in the Storage of Çökelek Cheese

“…EO T is especially rich in α-and β-turmerone and ar-turmerone [15]. It was reported that the EO T from rhizomes had an antibacterial effect on P. vulgaris, K. pneumoniae [16,17], and B. cereus and B. subtilis [18] but did not affect S. typhimurium, S. aureus, E. coli and L. monocytogenes [19,20].…”