Antibiotics in Combination with Antifungals to Combat Drug Resistant Candida – A Concept on Drug Repurposing

Monalis, Hannah; Sujith, R.; Leela, K.V.; Balamurali, V.

doi:10.9734/jamb/2020/v20i830274

Cited by 3 publications

(1 citation statement)

References 27 publications

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“…However, recent studies in the United States, Europe, and Asia have shown increased resistance of Candida species to fluconazole and echinocandins [ 5 , 11 ]. Due to the limitations of antifungal agents and the development of antifungal resistance, combination therapy can be an effective strategy for the therapeutic challenges of candidiasis caused by resistant species [ 21 ]. Studies of antifungal drugs with different mechanisms of action against Candida species have also been performed.…”

Section: Discussionmentioning

confidence: 99%

In vitro interactions of nystatin and micafungin combined with chlorhexidine against candida albicans isolates

Salehi

Shafaroudi

Daryani

et al. 2022

CMM

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Background and Purpose: Oral candidiasis has become a growing problem in hospitals worldwide, and the development of antifungal drug resistance in Candida species constitutes a serious concern. This study aimed to evaluate the in vitro efficacy of nystatin, and micafungin with chlorhexidine against fluconazole-resistant and fluconazole-sensitive Candida albicans (C. albicans) isolates. Materials and Methods: In this experimental-laboratory study, a total of 20 fluconazole-resistant (n=10) and fluconazole-susceptible (n=10) C. albicans strains were obtained from the reference culture collection of the Invasive Fungi Research Center in Mazandaran University of Medical Sciences, Sari, Iran. In vitro combination of nystatin and micafungin with chlorhexidine was performed using a microdilution checkerboard method based on the Clinical and Laboratory Standards Institute guideline. Results: Micafungin had the highest antifungal activity against C. albicans susceptible and resistant strains, with a Geometric mean of (GM) =0.008µg/ml and GM=0.008µg/ml, followed by nystatin with GM=0.06µg/ml and GM=0.042µg/ml and chlorhexidine with GM=0.25µg/ml and GM=0.165µg/ml against C. albicans resistant and sensitive strains, respectively. The interaction of micafungin and nystatin with chlorhexidine showed a synergistic interaction against most C. albicans strains. In addition, no antagonistic interaction was observed between micafungin, nystatin, and chlorhexidine against C. albicans strains. Conclusion: The synergistic interaction of micafungin with chlorhexidine against azoleresistant C. albicans suggests an alternative approach to overcome antifungal drug resistance. However, further studies are needed for in vivo evaluation.

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Section: Discussionmentioning

confidence: 99%

In vitro interactions of nystatin and micafungin combined with chlorhexidine against candida albicans isolates

Salehi

Shafaroudi

Daryani

et al. 2022

CMM

View full text Add to dashboard Cite

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Herbal Products and Their Active Constituents Used Alone and in Combination with Antifungal Drugs against Drug-Resistant Candida sp.

Herman¹,

Herman

2021

Antibiotics

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Clinical isolates of Candida yeast are the most common cause of opportunistic fungal infections resistant to certain antifungal drugs. Therefore, it is necessary to detect more effective antifungal agents that would be successful in overcoming such infections. Among them are some herbal products and their active constituents.The purpose of this review is to summarize the current state of knowledge onherbal products and their active constituents havingantifungal activity against drug-resistant Candida sp. used alone and in combination with antifungal drugs.The possible mechanisms of their action on drug-resistant Candida sp. including (1) inhibition of budding yeast transformation into hyphae; (2) inhibition of biofilm formation; (3) inhibition of cell wall or cytoplasmic membrane biosynthesis; (4) ROS production; and (5) over-expression of membrane transporters will be also described.

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Effectiveness of drug repurposing approach against Candida isolates

Ansari,

Saini,

Kumar

et al. 2024

ECJ

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Over the past three decades, there has been an increase in the severity of fungal infections, affecting several individuals and claiming the lives of more than 1.6 million people every year. Species of Candida are one of the causatives of invasive fungal infections, and the extensive use of antifungals for their treatment has led to the emergence of drug resistance in these species, highlighting the need for the exploration of effective and cost-effective therapeutics. Drug repurposing is an important solution for alternative therapeutics. There are many studies where antifungal indications of any existing drug have been analyzed with an aim to establish new antimycotic therapeutics in a short time and with a lower budget. In this review, efforts are made to compile the literature on repurposed drugs against clinical isolates of Candida and fungal pathogens to better illustrate drug repurposing's role in the treatment of candidiasis.

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Antibiotics in Combination with Antifungals to Combat Drug Resistant Candida – A Concept on Drug Repurposing

Cited by 3 publications

References 27 publications

In vitro interactions of nystatin and micafungin combined with chlorhexidine against candida albicans isolates

In vitro interactions of nystatin and micafungin combined with chlorhexidine against candida albicans isolates

Herbal Products and Their Active Constituents Used Alone and in Combination with Antifungal Drugs against Drug-Resistant Candida sp.

Effectiveness of drug repurposing approach against Candida isolates

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