Antibiotics in surface water of East and Southeast Asian countries: A focused review on contamination status, pollution sources, potential risks, and future perspectives

Anh, Hoang Quoc; Le, Thi Phuong Quynh; Le, Nhu D.; Lu, Xixi; Duong, Thi Thuy; Garnier, Josette; Rochelle‐Newall, Emma; Zhang, Shurong; Oh, Neung‐Hwan; Oeurng, Chantha; Ekkawatpanit, Chaiwat; Dat, Nguyen Tien; Nguyen, Quang Trung; Nguyen, Tran Dung; Nguyen, Trong-Nghia; Tran, Thi Lieu; Kunisue, Tatsuya; Tanoue, Rumi; Takahashi, Shin; Minh, Tu Binh; Le, Huu Tuyen; Thị, Ngọc Mai Phạm; Nguyen, Thi Anh Huong

doi:10.1016/j.scitotenv.2020.142865

Cited by 274 publications

(89 citation statements)

References 129 publications

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“…It is estimated that antibiotic resistance may lead to 10 million deaths per year by 2050 [31]. Misuse of antimicrobial agents is the main cause of antibiotic resistance in pathogenic bacteria, particularly in developing nations [32][33][34]. In this study, our results indicate that SXT resistance was the most predominant (56.0%) among the 125 K. oxytoca isolates of aquatic animal origins.…”

Section: Discussionmentioning

confidence: 53%

First Experimental Evidence for the Presence of Potentially Virulent Klebsiella oxytoca in 14 Species of Commonly Consumed Aquatic Animals, and Phenotyping and Genotyping of K. oxytoca Isolates

Chen

2021

Antibiotics

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Klebsiella oxytoca is a recently emerging pathogen that can cause necrotizing enterocolitis, hemorrhagic colitis, sepsis-associated purpura fulminans, and infective endocarditis in humans. The bacterium is ubiquitous in water and soil environments. Nevertheless, current literature on K. oxytoca in aquatic products is rare. In this study, we surveyed K. oxytoca contamination in 41 species of consumable aquatic animals sold in July, August, and September of 2018 and 2019 in Shanghai, China, 40 of which had no history of carrying this bacterium. K. oxytoca was for the first time isolated from 14 species with high abundance in benthic animals. None of the K. oxytoca isolates (n = 125) harbored toxin genes mviM, tisB, and yqgB. However, a high occurrence of virulence-associated genes was observed, including brkB (73.6%), cdcB (66.4%), pduV (64.8%), and virk (63.2%). Resistance to sulphamethoxazole-trimethoprim (56.0%) was the most predominant among the isolates, followed by chloramphenicol (6.4%), tetracycline (5.6%), and kanamycin (3.2%). Approximately 8.0% of the isolates displayed multidrug resistant phenotypes. Meanwhile, high percentages of the isolates tolerated the heavy metals Cu2+ (84.8%), Pb2+ (80.8%), Cr3+ (66.4%), Zn2+ (66.4%), and Hg2+ (49.6%). Different virulence and resistance profiles were observed among K. oxytoca isolates in 3 types and 14 species of aquatic animals. The ERIC-PCR-based genome fingerprinting of the 125 K. oxytoca isolates revealed 108 ERIC genotypes with 79 singletons, which demonstrated the genetic diversity of the isolates. The results of this study fill gaps for policy and research in the risk assessment of K. oxytoca in consumable aquatic animals.

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Section: Discussionmentioning

confidence: 53%

First Experimental Evidence for the Presence of Potentially Virulent Klebsiella oxytoca in 14 Species of Commonly Consumed Aquatic Animals, and Phenotyping and Genotyping of K. oxytoca Isolates

Chen

2021

Antibiotics

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“…Antibiotics refer to a class of secondary metabolites produced by microorganisms (bacteria, fungi, and actinomycetes) or higher animals and plants with antipathogen functions, which interfere with other environmental organisms’ normal metabolisms and growth. It has been widely used in a wide range of fields such as agriculture, medical treatment, and animal husbandry for decades, and the followed contamination of antibiotics has received increasing attention [ 66 , 67 ].…”

Section: Paper-based Sensor For Biomolecule Sensingmentioning

confidence: 99%

Hospitals and Laboratories on Paper-Based Sensors: A Mini Review

Zhang

Xia

Feng

et al. 2021

Sensors

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With characters of low cost, portability, easy disposal, and high accuracy, as well as bulky reduced laboratory equipment, paper-based sensors are getting increasing attention for reliable indoor/outdoor onsite detection with nonexpert operation. They have become powerful analysis tools in trace detection with ultra-low detection limits and extremely high accuracy, resulting in their great popularity in medical detection, environmental inspection, and other applications. Herein, we summarize and generalize the recently reported paper-based sensors based on their application for mechanics, biomolecules, food safety, and environmental inspection. Based on the biological, physical, and chemical analytes-sensitive electrical or optical signals, extensive detections of a large number of factors such as humidity, pressure, nucleic acid, protein, sugar, biomarkers, metal ions, and organic/inorganic chemical substances have been reported via paper-based sensors. Challenges faced by the current paper-based sensors from the fundamental problems and practical applications are subsequently analyzed; thus, the future directions of paper-based sensors are specified for their rapid handheld testing.

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“…Moreover, antibiotic residues can accelerate the production of antibiotic-resistant bacteria and antibiotic-resistant genes even at low concentrations, which could be a major threat to public health globally [2,3]. Extensive studies have reported that antibiotic compounds originating from HWW can be transported to ponds, rivers, and wastewater treatment plants [4].…”

Section: Introductionmentioning

confidence: 99%

Removal of Antibiotics from Real Hospital Wastewater by Cold Plasma Technique

Nguyen

Tran

et al. 2021

Journal of Chemistry

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Hospital wastewater contains a complex mixture of bioactive substances and microorganisms that are deleterious to humans and aquatic animals. In this study, four antibiotics, namely, ofloxacin, ciprofloxacin, cefuroxime, and amoxicillin, respectively, from the wastewater of seven hospitals in Ho Chi Minh City, Vietnam, were monitored. The results revealed that the wastewater from these hospitals is contaminated with at least one of the antibiotics. In addition, the degradation capacity of the antibiotics by the wastewater treatment plant at one of the hospitals by the cold plasma technique was investigated. Furthermore, effects of the variation in pH, interelectrode distance, applied voltage, and reaction time on the removal efficiency were investigated in terms of the reduction in antibiotics concentration, COD, and ammonia. Ciprofloxacin, cefuroxime, COD, and ammonia were almost eliminated, while ofloxacin and amoxicillin were reduced by more than 72% under optimum conditions (initial pH of 10, reaction time of 15 min, applied voltage of 30 kV, and interelectrode distance of 10 mm). All of these factors affected the removal efficiency. The removal efficiency was most robust in the first 5 min, and it increased with the increase in the reaction time. However, the removal efficiency tended to saturate over time, while it decreased with the increase in the reaction time. With an applied voltage of 30 kV onwards, the removal efficiency was not significantly different. Most of the pollutants were predominately eliminated under slightly alkaline conditions (pH of ∼10). In addition, primary oxidants in the aqueous phase, such as O3, H2O2, and ⋅OH, were generated. Besides, the obtained results also revealed that the decomposition of ciprofloxacin and cefuroxime follows the first-order reaction kinetics; meanwhile, the third-order reaction kinetics was most likely for the decomposition of ofloxacin and amoxicillin.

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Antibiotics in surface water of East and Southeast Asian countries: A focused review on contamination status, pollution sources, potential risks, and future perspectives

Cited by 274 publications

References 129 publications

First Experimental Evidence for the Presence of Potentially Virulent Klebsiella oxytoca in 14 Species of Commonly Consumed Aquatic Animals, and Phenotyping and Genotyping of K. oxytoca Isolates

First Experimental Evidence for the Presence of Potentially Virulent Klebsiella oxytoca in 14 Species of Commonly Consumed Aquatic Animals, and Phenotyping and Genotyping of K. oxytoca Isolates

Hospitals and Laboratories on Paper-Based Sensors: A Mini Review

Removal of Antibiotics from Real Hospital Wastewater by Cold Plasma Technique

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