Antibodies to Herpesvirus Hominis Types 1 and 2 in Humans

Nahmias, André J.; Josey, William E.; Naib, Zuher M.; Luce, Carolyn F.; Guest, Beverly A.

doi:10.1093/oxfordjournals.aje.a121166

Cited by 222 publications

(105 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In any event, this observation seems to have some relevance to the close relationship between HSV-2 and cervical cancer [11][12][13].…”

Section: Discussionmentioning

confidence: 72%

“…For the latter, a mode of venereal transmission has been implied [9]. It was further suggested that HSV-2 might be associated with uterine cervical cancer [11][12][13].The primary purpose of the present study was to determine whether and how frequently HSV-2 could be isolated from genital herpes infections, notably of females, in this country. As the criterion on which to determine the types, Hampar et al's neutralization technique using type-specific hyperimmune rabbit IgM and complement [4] was employed.…”

mentioning

confidence: 98%

“…For the latter, a mode of venereal transmission has been implied [9]. It was further suggested that HSV-2 might be associated with uterine cervical cancer [11][12][13].…”

mentioning

confidence: 99%

See 2 more Smart Citations

Typing of Herpes Simplex Virus Strains of Genital and Nongenital Origins

Kawana

Shinkai

Yoshino

1974

Japanese Journal of Microbiology

View full text Add to dashboard Cite

Herpes simplex virus strains isolated from genital and nongenital sites were classified into type 1 (HSV-1) and type 2 (HSV-2) by endpoint neutralization tests using IgM of rabbits hyperimmunized with either HF (HSV-1) or UW-268 (HSV-2) strain. It was found that about one-third of the genital isolates belonged to type 1, in contrast to the general concept that HSV-2 represents genital herpes strains. These HSV-1 strains, differing from HSV-2, were mostly isolates from acute herpetic lesions of female patients with constitutional symptoms. On the other hand, all nongenital isolates except one were determined to be HSV-1. There was no intermediate type equally neutralizable by both types of IgM. A majority of the HSV-2 strains produced large plaques in chick embryo (CE) cells before passage through avian cells. In contrast, all HSV-1 strains failed to produce such large CE plaques even after serial passages through avian hosts.Herpes simplex virus (HSV) can be classified into two distinct types, HSV-1 and HSV-2, on the basis of antigenical analyses [2,6,8,9,15]. The correlation between the type and the site of isolation adds importance from the clinical and epidemiological viewpoints. It has been documented that HSV-1 is isolated mainly from nongenital and HSV-2 from genital lesions. For the latter, a mode of venereal transmission has been implied [9]. It was further suggested that HSV-2 might be associated with uterine cervical cancer [11][12][13].The primary purpose of the present study was to determine whether and how frequently HSV-2 could be isolated from genital herpes infections, notably of females, in this country. As the criterion on which to determine the types, Hampar et al's neutralization technique using type-specific hyperimmune rabbit IgM and complement [4] was employed.An additional purpose was to find a simple method for type determination as a substitute for the cumbersome serological procedure. The chick embryo (CE) cell plaque marker of Figueroa and Rawls [3] and Lowry et al [7] was thought suitable for this purpose, and all the isolates were tested for their ability to form plaques in CE cells. Results of these experiments are described in this communication. MATERIALS AND METHODSViruses. Specimens for virus isolation were collected in the gynecological ward of the University of Tokyo Hospital, Tokyo, the National Cancer Center Hospital, Tokyo, and the Department of Dermatology of Toranomon Hospital, Tokyo, by applying swabs to lesions, which were immediately rinsed in a maintenance medium containing appropriate concentrations of penicillin and streptomycin. The rinse was inoculated into Vero cell cultures. The maintenance medium used was Eagle's minimum essential medium (MEM) supplemented with 2% calf serum. In cases that typical cytopathic effects were noted the culture fluid was harvested and Requests for reprints should be addressed to Dr.

show abstract

“…In any event, this observation seems to have some relevance to the close relationship between HSV-2 and cervical cancer [11][12][13].…”

Section: Discussionmentioning

confidence: 72%

mentioning

confidence: 98%

See 1 more Smart Citation

Typing of Herpes Simplex Virus Strains of Genital and Nongenital Origins

Kawana

Shinkai

Yoshino

1974

Japanese Journal of Microbiology

View full text Add to dashboard Cite

show abstract

“…All 45 sera were examined, and the titer of anti HSV type 1 and HSV type 2 antibodies was determinated. The presence of latent HSV type 1 and type 2 infection was diagnosed on the basis of these findings [9].…”

Section: Methodsmentioning

confidence: 99%

Herpes simplex virus infection in women with previous spontaneous abortion

Bujko¹,

Sulović²,

Živanovic³

et al. 1988

Jpme

View full text Add to dashboard Cite

“…saimiri, (HVS) invariably causes lethal lymphatic leukemia or reticulum cell sarcoma in a number of primates (8,9); (iv) A herpesvirus is the most probable etiological agent of the Lucke frog kidney carcinoma (10); (v) More tentative suggestions have been made about possible links between herpes simplex type 2 and human cervical carcinoma (11) and between EBV and nasopharyngeal carcinoma (12)(13)(14).…”

mentioning

confidence: 99%