Antibodies to human papillomavirus and to other genital infectious agents and invasive cervical cancer risk

Jha, Prabhat; Beral, V; Pike, M. C.; Hermon, C; Peto, J; Deacon, Judith; Chilvers, Claire; Mp, Vessey; Mant, David; Gissmann, Lutz; Müller, Martin; Hack, Stephen P.

doi:10.1016/0140-6736(93)93128-n

Cited by 71 publications

(38 citation statements)

References 11 publications

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“…Viral proteins may be accumulated sufficiently around the infected cells during this period. According to some clinical studies, the most consistent findings have been that the presence of serum Abs to the transforming E6 and E7 proteins of the virus is associated with invasive cancer compared with the sera of controls (51,52). These reports suggested the presence of circulating E6 and E7 proteins in cervical cancer patients.…”

Section: Discussionmentioning

confidence: 63%

Both E6 and E7 Oncoproteins of Human Papillomavirus 16 Inhibit IL-18-Induced IFN-γ Production in Human Peripheral Blood Mononuclear and NK Cells

Lee

Cho

et al. 2001

The Journal of Immunology

111

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Cervical carcinoma is the predominant cancer among malignancies in women throughout the world, and human papillomavirus (HPV) 16 is the most common agent linked to human cervical carcinoma. The present study was performed to investigate the mechanisms of immune escape in HPV-induced cervical cancer cells. The presence of HPV oncoproteins E6 and E7 in the extracellular fluids of HPV-containing cervical cancer cell lines SiHa and CaSki was demonstrated by ELISA. The effect of HPV 16 oncoproteins E6 and E7 on the production of IFN-γ by IL-18 was assessed. E6 and E7 proteins reduced IL-18-induced IFN-γ production in both primary PBMCs and the NK0 cell line. FACS analysis revealed that the viral oncoproteins reduced the binding of IL-18 to its cellular surface receptors on NK0 cells, whereas there was no effect of oncoproteins on IL-1 binding to its surface IL-1 receptors on D10S, a subclone of the murine Th cell D10.G4.1. In vitro pull-down assays also revealed that the viral oncoproteins and IL-18 bound to IL-18R α-chain competitively. These results suggest that the extracellular HPV 16 E6 and E7 proteins may inhibit IL-18-induced IFN-γ production locally in HPV lesions through inhibition of IL-18 binding to its α-chain receptor. Down-modulation of IL-18-induced immune responses by HPV oncoproteins may contribute to viral pathogenesis or carcinogenesis.

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Section: Discussionmentioning

confidence: 63%

Both E6 and E7 Oncoproteins of Human Papillomavirus 16 Inhibit IL-18-Induced IFN-γ Production in Human Peripheral Blood Mononuclear and NK Cells

Lee

Cho

et al. 2001

The Journal of Immunology

111

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show abstract

“…On the other hand, several studies in literature have failed to demon strate significant association between Clamydia and cervical pre neoplasia and cancer [9,13,15,18,19,22,33,68]. Lazenby GB et al, had not found any case of Chlamydia trachomatis using the technique of rRNA detection by TMA [48].…”

Section: B Prevalence Of General Population and In Patients With Ca Ormentioning

confidence: 99%

Association of Genital Infections Other Than Human Papillomavirus with Pre-Invasive and Invasive Cervical Neoplasia

Ghosh

Mandal

Kundu

et al. 2016

JCDR

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“…52 Such cells express SV40-LT at 33°C (proliferative phenotype), but do not express this protein at 37°C (nonproliferative phenotype). Immortalization induced by SV40-LT involves interference with the tumor suppressors p53 and pRB, 53 and is dependent on Ras signaling.…”

Section: Immortalization Increases the Permissiveness Of Schwann Cellmentioning

confidence: 99%

Ras Signaling Influences Permissiveness of Malignant Peripheral Nerve Sheath Tumor Cells to Oncolytic Herpes

Farassati

Pan

Yamoutpour

et al. 2008

The American Journal of Pathology

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Antibodies to human papillomavirus and to other genital infectious agents and invasive cervical cancer risk

Cited by 71 publications

References 11 publications

Both E6 and E7 Oncoproteins of Human Papillomavirus 16 Inhibit IL-18-Induced IFN-γ Production in Human Peripheral Blood Mononuclear and NK Cells

Both E6 and E7 Oncoproteins of Human Papillomavirus 16 Inhibit IL-18-Induced IFN-γ Production in Human Peripheral Blood Mononuclear and NK Cells

Association of Genital Infections Other Than Human Papillomavirus with Pre-Invasive and Invasive Cervical Neoplasia

Ras Signaling Influences Permissiveness of Malignant Peripheral Nerve Sheath Tumor Cells to Oncolytic Herpes

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