Anticancer Activity of<i>Maytenus emarginata</i>Leaves and Stems: A Comparative Study

Nagaveni, P.; Mohan, G. Krishna; Gaikwad, Switi B.

doi:10.5958/0975-4385.2015.00017.5

Cited by 4 publications

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“…Ayurvedic classic works of literature have evidence of the variety of herbs for the purpose of cancer. 3,4 80% of the medicine used before the 20 th century was obtained from the medicinal plants' leaves, barks and roots. During that time crude botanicals were extracted in fluid like water, milk, and alcohol and the extract was prescribed to the patients.…”

Section: Introductionmentioning

confidence: 99%

In-vitro Anticancer Activity of Various Plant Extracts

Mishra¹,

Dash²,

Mohapatra³

2023

IJPQA

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Herbal medicinal plants have been explored for a variety of pharmacological properties but still a large number of phytoconstituents are still unexplored. The manuscript aims to assess the anticancer property of Leucas cephalotes (Roth) Spreng, Acalypha indica L. and Lantana camara L. extracts on MDA-MB-231, A-549, PC-3 and Hep-G2 cell lines. The ethanol extract of the selected plants was explored for anticancer activity by SRB assay. Since L. camara exhibited promising activity, this plant’s successive extraction in diff erent extracts (n-hexane, chloroform, ethanol and hydroalcoholic) was further studied. All the extracts were screened for anticancer activity by SRB assay on MDA-MB-231 and A-549 cell lines. Additionally, the apoptotic assay was carried out on n-hexane and chloroform extracts on A-549 cell lines. GCMS also analyzed both extracts for characterization of the phytoconstituents. Obtained data indicate that n-Hexane and chloroform extracts of L. camara showed promising anticancer activity on MDA-MB-231 and A-549 cell lines. Both extracts also induced apoptosis in A-549 cell line. GC-MS data of L. camara extracts revealed the presence of 25 and 19 compounds in n-hexane and chloroform extract, respectively. The present study shows that L. camara has strong anticancer properties against lung cancer cell lines compared to breast, prostate, and hepatoma cancer cell lines

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Section: Introductionmentioning

confidence: 99%

In-vitro Anticancer Activity of Various Plant Extracts

Mishra¹,

Dash²,

Mohapatra³

2023

IJPQA

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Evaluation of Cytotoxicity of normal Vero and Anticancer Activity of Human Breast Cancer Cell Lines by Aqueous Unripe Fruit Extract of Solanum torvum

Shanthi¹,

Saravanan²

2021

RJPT

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In the present study aqueous extract of Solanum torvum unripe fruits was used to evaluate its cytotoxic effect and anticancer activity through in vitro studies by 3-(4, 5 dimethyl thiazole-2-yl)-2, 5-diphenyl tetrazolium bromide- MTT assay) on Normal VERO cell line and MCF-7 (Human breast adenocarcinoma cell line). Aqueous extracts of Solanum torvum unripe fruits was found to be effective in the prevention of cell proliferation by breast adenocarcinoma cell lines at 1000 µg/ml from the results obtained during 24 hours of incubation.

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In-vitro Cytotoxicity assay of Betel quid extract against HeLa cells

Usharani

Monisha

2022

RJPT

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HeLa cells are broadly used for in-vitro studies in bringing out the medicinal value of plants against some dreadful diseases. From time immemorial, it is well proven that plant extracts play a vital role in treating many diseases including cancer. The plant extract contains copious varied phenolic compounds and flavonoids that are majorly responsible for its medicinal properties. In our study we have focused on the extraction of betel quid (betel leaves, areca nut and slaked lime in an appropriate proportion) using the solvent hexane. The hexane extract of the betel quid was evaluated for in vitro studies of apoptosis of HeLa cells. The results revealed that hexane extract of the betel quid at the maximum concentration of 200 µg/mL was very effective and only 20.89 % of cells were viable. The cytotoxic effect against HeLa cells was significant with IC50 of 96.33μg/ml. Further studies can be done on concentrating the bioactive compounds responsible for the anticancer activity. The bioactive active compounds can be formulated in the treatment of cancer in the upcoming research.

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Anticancer Activity ofMaytenus emarginataLeaves and Stems: A Comparative Study

Cited by 4 publications

References 0 publications

In-vitro Anticancer Activity of Various Plant Extracts

In-vitro Anticancer Activity of Various Plant Extracts

Evaluation of Cytotoxicity of normal Vero and Anticancer Activity of Human Breast Cancer Cell Lines by Aqueous Unripe Fruit Extract of Solanum torvum

In-vitro Cytotoxicity assay of Betel quid extract against HeLa cells

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