Anticancer activity of Rhein isolated from Cassia fistula L. flower

Duraipandiyan, Veeramuthu; Arul, Albert-Baskar; Ignacimuthu, Savarimuthu; Muthukumar, C; Al-Harbi, NA

doi:10.1016/s2222-1808(12)60213-8

Cited by 61 publications

(45 citation statements)

References 27 publications

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“…Approximately one third of the top selling drugs in the world are natural products or their derivatives often with ethnopharmacological background [31][32][33][34] . According to Chatterjee et al [35] , by tribal healers in most of the countries, the ethnomedical treatment is frequently used to treat skin infection, swelling, mental illness, ageing, diabetes, jaundice, cancer, scabbies, snake bite and venereal diseases.…”

Section: Discussionmentioning

confidence: 99%

Antiproliferative role of Indigofera aspalathoides on 20 methylcholanthrene induced fibrosarcoma in rats

Kumar

Rao

Balasubramanian

2012

Asian Pacific Journal of Tropical Biomedicine

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Section: Discussionmentioning

confidence: 99%

Antiproliferative role of Indigofera aspalathoides on 20 methylcholanthrene induced fibrosarcoma in rats

Kumar

Rao

Balasubramanian

2012

Asian Pacific Journal of Tropical Biomedicine

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“…Apoptosis in early stages was 2.29% at 6.25 µg/ml and at late stages it was 1.94%. When the concentration was increased to 12.5 µg/ml, apoptosis was 4.36% at early stages and 5.61% at late stages respectively [21].…”

Section: Duraipandiyan Et Al (2012)mentioning

confidence: 97%

Medicinal plants: used in Anti-cancer treatment

Tyagi¹,

Sharma²,

Shrivastava³

et al. 2017

IJRDPL

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ABSTRACT:Globally cancer is a disease which severely effects the human population. There is a constant demand for new therapies to treat and prevent this life -threatening disease. The plant kingdom produces naturally occurring secondary metabolites which are being investigated for the anticancer activities for the development of new clinical drugs. For many years herbal medicines have been used and are still used in developing countries as the primary source of medical treatment. Plants have been used in the medicine for their natural antiseptic properties. Thus, research has developed into the investigating the potential properties and uses of terrestrial plants extracts for the preparation of potential nanomaterial drugs for diseases including cancer. Many plant species are already being used to treat or prevent development of cancer. This review discusses the demand for naturally derived compounds from medicinal plants and their properties which make them targets for potential anticancer treatments.

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“…It has been used in folk medicine to cure burns, constipation, convulsion, depression, dysurea, worm infestation etc. 4 Several pharmacological activities of cassia fistula L. including antioxi-dant, [5][6][7] CNS depressant, 8 wound healing, 9 antifungal and antibacterial, 10 antitumor, 11,12 anti-fertility, 13 hepatoprotective 14 and anti-diabetic 15 have been reported.…”

Section: Cassia Fistula L (Commonly Known As Indian Laburnum)mentioning

confidence: 99%

Anticonvulsant and anxiolyic activities of ethyl acetate fraction of Cassia fistula Linn. pods in mice

Kalaiyarasi¹,

Karthika²,

Ragupathi³

2014

Phcog Commn.

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Context: Cassia fistula L. (Leguminacea) is used by Indian and Tanzanian traditional healers for treating various ailments related to the central nervous system. Aims: The present study aimed to evaluate the anticonvulsant and anxiolytic activity of the ethyl acetate fraction obtained from a hydroalcoholic extraction of Cassia fistula pods (EAFCF) and thereby to provide scientific validation for its traditional use. Methods: Preliminary phytochemical analysis and estimation of the flavonoid content of the ethyl acetate fraction was performed. Anticonvulsant activity was assessed by the subcutaneous pentylenetetrazole test (s.c. PTZ test). Anxiolytic activity was assessed by elevated plus maze (EPM) and open field tests (OFT). The sedative and motor toxicity was evaluated by a phenobarbitone induced sleep test and rotarod behavior respectively. Results: Photochemical analysis revealed the presence of a high flavanoid content in the ethyl acetate fraction. Treatment of EAFCF (50 and 100 mg/kg) significantly increased the latency to the onset of minimal clonic seizure and generalized tonic clonic seizure and animals were completely protected from death due to PTZ administration. Administration of EAFCF at the dose of 100 mg/kg markedly increased the open arm entries and time spent in open arm in EPM. In OFT, EAFCF increased the number of central squares crossed and time spent in the central compartment. EAFCF in the doses used in this experiment did not produce sedation or motor toxicity. Conclusion: The results obtained herein clearly indicate the anticonvulsant and anxiolytic activity of EAFCF which may be due to the high flavonoid content. These findings give the scientific support for common use of this plant for treating epilepsy and anxiety.

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Anticancer activity of Rhein isolated from Cassia fistula L. flower

Cited by 61 publications

References 27 publications

Antiproliferative role of Indigofera aspalathoides on 20 methylcholanthrene induced fibrosarcoma in rats

Antiproliferative role of Indigofera aspalathoides on 20 methylcholanthrene induced fibrosarcoma in rats

Medicinal plants: used in Anti-cancer treatment

Anticonvulsant and anxiolyic activities of ethyl acetate fraction of Cassia fistula Linn. pods in mice

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