Anticancer and cytotoxic properties of the latex of Calotropis procera in a transgenic mouse model of hepatocellular carcinoma

Choedon, Tenzin; Mathan, Ganeshan; Arya, Soneera; Kumar, Vijay

doi:10.3748/wjg.v12.i16.2517

Cited by 109 publications

(57 citation statements)

References 26 publications

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“…Van Quaquebeke et al (2005) isolated a natural cardiotonic steroid from the methanolic extract of C. procera root barks called 2 -oxovoruscharin and developed a new hemisynthetic cardenolide derivative named UNBS1450 which display in vitro antiproliferative action comparable to taxol, while the latex shows cytotoxicity corroborated by morphological alterations in leukemia cells, such as chromatin condensation, DNA fragmentation and cell volume reduction (Choedon et al 2006, Oliveira et al 2007. It is established that cardiotonic steroid glycosides (bufalin and digoxin, for instance) are capable to kill cancer cells through the activation of apoptotic pathways (McConkey et al 2000, Kurosawa et al 2001).…”

Section: Resultsmentioning

confidence: 99%

In vitro and in vivo antiproliferative activity of Calotropis procera stem extracts

Magalhães

Ferreira

Moura

et al. 2010

An. Acad. Bras. Ciênc.

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The cytotoxic potential of stem organic extracts from Calotropis procera (Asclepiadaceae) was firstly evaluated against cancer cell lines by MTT assay. Subsequently, samples considered cytotoxic were tested for antimitotic activity on sea urchin egg development and for in vivo antiproliferative activity in mice bearing Sarcoma 180 tumor. Among the five extracts (hexane, dichloromethane, ethyl acetate, acetone and methanol), ethyl acetate and acetone extracts displayed higher cytotoxic potential against tumor cells, with IC 50 ranging from 0.8 to 4.4 μg/mL, while methanolic extract was weakly cytotoxic. Cytotoxic extracts also exhibited cell division inhibition capacity by antimitotic assay, revealing IC 50 values lower than 5 μg/mL. In the in vivo antitumor assessments, ethyl acetate-and acetone-treated animals showed tumor growth inhibition ratios of 64.3 and 53.1%, respectively, with reversible toxic effects on liver and kidneys. Further studies are in progress in order to identify C. procera cytotoxic compound(s) and to understand the mechanism of action responsible for this tumor-decreasing potential.

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Section: Resultsmentioning

confidence: 99%

In vitro and in vivo antiproliferative activity of Calotropis procera stem extracts

Magalhães

Ferreira

Moura

et al. 2010

An. Acad. Bras. Ciênc.

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“…Different parts of the plant have been used as anthelmintic, purgative and in diseases such as ulcer and leprosy. The latex of this plant possess antidiarheal [4], antidiabetic [5], anticancer properties [6], and antipyretic analgesic [7]. The root extract is reported to have antitumor [8], anti-inflammatory, and analgesic effects [9].…”

Section: Introductionmentioning

confidence: 99%

Hepatoprotective Effects of Polyherbal Formulation Against Carbon Tetrachloride-Induced Hepatic Injury in Albino Rats: A Toxicity Screening Approach

Yogi¹,

Mishra²

2016

Asian J Pharm Clin Res

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Objective: To investigate the hepatoprotective activity of aqueous methanolic extract of polyherbal formulation and individual extracts of Calotropis procera, Gymnema sylvestre, and Lawsonia inermis leaves. Methods:The hepatoprotective activity of the formulation and extracts were assessed on the basis of histopathological changes in liver of carbon tetrachloride-induced hepatotoxic rats. Results:The result of present studies strongly indicates that the hepatoprotective property of polyherbal formulation as evidenced by less damaged hepatocytes cells. Conclusion:Polyherbal formulation revealed excellent hepatoprotective profile as compared to individual plants due to synergistic effect produced by different phytochemicals present in the formulation.

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“…Stem organic extracts also possess anti-tumor activity against mice bearing Sarcoma 180 tumors 35 . The chemopreventive effects of C. procera latex is reported through the inhibition of different mediators of inflammation with selective cytotoxicity independent of intrinsic pathway of apoptosis against hepatocellular carcinoma in the X15-myc transgenic mouse model 36 . To reveal the probable phyto-chemicals responsible for anti-cancer effect, focus has been directed towards heat-stable latex proteins from C. procera due to its inhibitory activities on sarcoma 180 growth 37 .…”

Section: 7mentioning

confidence: 99%

Anti-cancer potential of South Asian plants

Rahman

2013

Nat. Prod. Bioprospect.

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Phyto-chemicals are increasingly being used in the treatment of cancer because of their availability, potential anti-cancer activity with less adverse effects when compared with chemotherapy. The variation of climate and geography in South Asian countries provides a nursing environment for the growth of versatile plant species, that are repeatedly drawing attention of the scientific community. In this review, we have focused on the anti-cancer potential of thirty plants, which are commonly found in Bangladesh, India, Nepal, Pakistan and Sri Lanka, with their mechanisms of action. In particular, we have discussed the bio-active components that display anti-cancer activity, which have been identified in these plants. This review may help researchers to profile plants with known anti-cancer effect of this region and further investigations of anti-cancer agents in medicinal plants from South Asia.

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Anticancer and cytotoxic properties of the latex of Calotropis procera in a transgenic mouse model of hepatocellular carcinoma

Abstract: DL of C. procera has the potential for anti-cancer therapy due to its differentiable targets and non-interference with regular pathway of apoptosis.

Cited by 109 publications

References 26 publications

In vitro and in vivo antiproliferative activity of Calotropis procera stem extracts

In vitro and in vivo antiproliferative activity of Calotropis procera stem extracts

Hepatoprotective Effects of Polyherbal Formulation Against Carbon Tetrachloride-Induced Hepatic Injury in Albino Rats: A Toxicity Screening Approach

Anti-cancer potential of South Asian plants

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