Hepatoprotective Effects of Polyherbal Formulation Against Carbon Tetrachloride-Induced Hepatic Injury in Albino Rats: A Toxicity Screening  Approach

Yogi, Bhumika; Mishra, Ashutosh

doi:10.22159/ajpcr.2017.v10i1.14757

Cited by 8 publications

(5 citation statements)

References 17 publications

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“…Standard drug silymarin-treated group showed prominent regeneration of the cells with no fatty infiltration and evident necrosis. The study is supportive to the results obtained from the biochemical analysis [18].…”

Section: Asian J Pharm Clinsupporting

confidence: 89%

Amelioration of Acetaminophen-Induced Hepatotoxicity Using Solanum Torvum Sw. Fruit Extract in Wistar Rats

Senthilkumar

Sirajudeen

2019

Asian J Pharm Clin Res

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Objective: Ayurveda and Chinese pharmacopeia have highlighted the traditional medicinal uses of Solanum torvum Sw. The fruits are ethnomedical used in the treatment of liver and spleen enlargement, cough, and also used as a hematopoietic, antimicrobial, and analgesic agent. In the present study, the amelioration of acetaminophen (APAP)-induced hepatotoxicity of the aqueous extract of S. torvum Sw. fruits is evaluated. Methods: The hepatoprotective activity of the fruit extract against APAP insult was evaluated by assessing it is in vivo antioxidants status, membrane-bound adenosine triphosphatases (ATPases), and tricarboxylic acid (TCA) cycle marker enzymes and also through histopathological studies of the liver. Results: Administration of the aqueous fruit extract of the plant caused a significant increase in the in vivo antioxidant status as evident from the reduction in lipid peroxidation caused by APAP and improvement in the mitochondrial membrane stability which is proved from the activity of membrane-bound ATPases and TCA cycle marker enzymes. Histological studies also supported the fact that the plant extract proved to revive the architecture of the toxin damaged liver tissues in par with silymarin. The chemical pathological changes were consistent with histopathological observations suggesting marked hepatoprotective effect of the aqueous extract of S. torvum. Conclusion: The results showed that the extract of S. torvum Sw. fruits has hepatoprotective potential which may be due to the antioxidant activity of its phytoconstituents, especially flavonoids, alkaloids, phenolics, etc.

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Section: Asian J Pharm Clinsupporting

confidence: 89%

Amelioration of Acetaminophen-Induced Hepatotoxicity Using Solanum Torvum Sw. Fruit Extract in Wistar Rats

Senthilkumar

Sirajudeen

2019

Asian J Pharm Clin Res

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“…The results showed an increase in levels of SGOT and SGPT in rat blood after administration of carbon tetrachloride as seen in the negative control group. In normal rat, SGOT levels were 141±67.4 UI/L and SGPT 12.6±4.40 UI/L [23]. The ethyl acetate and n-butanol fraction lowers the SGOT and SGPT level.…”

Section: Hepatoprotective Activitymentioning

confidence: 86%

Antioxidant and Hepatoprotective Activity of Abelmoschus Manihot L. Medik Leaf Fraction Against Ccl4-Induced Liver Damage in Rats

2019

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Objective: The objective of this research was to determine the antioxidant and hepatoprotective activity of Abelmoschus manihot L. Medik (AMLM) leaves in carbon tetrachloride-induced liver damage in rats (Rattus norvegicus). Methods: Samples of dried leaf were macerated using 96% ethanol solvent to obtain a viscous extract. Fractionation was then performed using ethyl acetate and n-butanol solvent. The antioxidant activity test of each fraction was done by 1,1-diphenyl-2-picrylhydrazyl assay. For the hepatoprotective activity test, the fractions were suspended in Tween 20 0.4% solution with concentrations of 10 mg/mL and 20 mg/mL. Rats were divided into 6 treatment groups consisting of five rats/group. Group I (positive control) was given an oral suspension of Curcuma® tablet, Group II (negative control) was given Tween 20 0.4% solution, and Groups III and IV (ethyl acetate fraction) and V and VI (n-butanol fraction) were given fraction suspension. On the 1st–7th days, all groups were given the solution treatment, and on the 8th day, all groups were injected with CCl4 intraperitoneally and the treatment was continued until the 11th day. On the 12th day, the blood of rats was taken and then measured the serum glutamic oxaloacetic transaminase (SGOT) and serum glutamic pyruvic transaminase (SGPT). Results: The results of the antioxidant test showed that ethyl acetate and n-butanol fraction, respectively, had IC50 of 89.99 and 114.56 ppm.Measurement of SGOT showed the result for Groups I–VI, respectively, of 160±63.62, 260.53±18.98, 154.16±52.78, 177.43±13.70, 120.07±34.80, and 105.23±40.49 IU/L. Measurement of SGPT showed the result for Groups I–VI, respectively, of 101.87±29.24, 108.1±9.04, 57.73±49.05, 106.07±26.45, 66.9±20.05, and 146.63±84.89 UI/L. Conclusion: The results of this research indicated that the ethyl acetate and n-butanol fraction of AMLM leaves have the antioxidant andhepatoprotective activity.

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“…Figure 1 and Figure 2 illustrate the hepatotoxins utilised in the experiments to induce liver dysfunction in animal models, as well as the frequency with which each hepatotoxin was used. They include CCl 4 (Ahmad et al 2020;Arsul, Wagh & Mayee 2011;Balkrishna, Lochab & Varshney 2022;Bera et al 2012;Gurusamy et al 2010;Nipanikar, Chitlange & Nagore 2017;Said et al 2022;Sarhadynejad et al 2016;Yogi & Mishra 2017), thioacetamide (Balkrishna et al 2022), hydrogen peroxide (H 2 O 2 ) (Ndefo et al 2021), gentamicin (Aziz et al 2017), methotrexate (MTX) (Anila et al 2015), cadmium chloride (CdCl 2 ) (Singh et al 2023), D-galactosamine (Khan et al 2015;Sachdeva, Bajpai & Razdan 2013;Shetty et al 2020), alcohol (Dey et al 2020;Kanchana & Jayapriya 2013;Nipanikar et al 2017;Rafi Reshi et al 2022;Shetty et al 2018), cisplatin , isoniazid (INH) (Sankar, Rajkumar & Sridhar 2015), acetaminophen (Ali et al 2014;Fiaz et al 2017;Gupta et al 2013;Mayuren et al 2010;Nipanikar et al 2017;Patel et al 2013;Ray, Taraphdar & Gupta 2022;Saroj, Mani & Mishra 2012;Sen et al 2015;Shakya 2011;Shrivastava & Garg 2015;…”

Section: Review Findings and Discussionmentioning

confidence: 99%

Hepatoprotective activities of polyherbal formulations: A systematic review

Aladejana,

Aladejana

2023

Journal of Medicinal Plants for Economic Development

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Background: Liver diseases pose a substantial global public health challenge, encompassing conditions such as liver failure, hepatitis, cirrhosis and associated complications Safeguarding the liver becomes important as these conditions impact human health. Hepatoprotective agents play a pivotal role in mitigating liver damage caused by chemicals, drugs and toxins. Polyherbal formulations, combining botanical components from traditional medicine, offer a promising approach to addressing liver disorders. Their popularity arises from a multi-targeted strategy in treating complex diseases, marking a shift in focus toward these formulations.Aim: The study aimed to conduct a thorough review of the existing literature on the hepatoprotective activity of polyherbal formulations and provide a comprehensive overview of their mechanisms of action. This review provides the overview of the use of polyherbal formulations in the management of liver disease.Method: A systematic search of electronic databases, including : Scopus, Academia, Elsevier, Science Direct, Wiley, BioMed Central, PubMed, and Google Scholar, was conducted using a combination of keywords such as ‘polyherbal formulations’, ‘hepatoprotective’ and ‘liver diseases’. Studies published between January 2010 and April 2023 were included in the review.Results: A total of 61 articles were reviewed, and the studies showed that polyherbal formulations possess significant hepatoprotective activity against various hepatotoxic agents. The mechanisms of action of these formulations include antioxidant, antiinflammatory, antifibrotic and antiapoptotic effects. Additionally, some polyherbal formulations were found to stimulate liver regeneration, enhance bile secretion and promote detoxification processes.Conclusion: Polyherbal formulations have shown promising hepatoprotective activity, and their multitargeted approach to treating complex diseases makes them a potential alternative to conventional medicines. However, identifying the active compounds responsible for the hepatoprotective effects of these formulations and their pharmacokinetics and pharmacodynamics could provide insights into the development of new and effective drugs for liver disorders.Contribution: This article contributes to the growing body of literature on the potential of polyherbal formulations as hepatoprotective agents.

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Hepatoprotective Effects of Polyherbal Formulation Against Carbon Tetrachloride-Induced Hepatic Injury in Albino Rats: A Toxicity Screening Approach

Cited by 8 publications

References 17 publications

Amelioration of Acetaminophen-Induced Hepatotoxicity Using Solanum Torvum Sw. Fruit Extract in Wistar Rats

Amelioration of Acetaminophen-Induced Hepatotoxicity Using Solanum Torvum Sw. Fruit Extract in Wistar Rats

Antioxidant and Hepatoprotective Activity of Abelmoschus Manihot L. Medik Leaf Fraction Against Ccl4-Induced Liver Damage in Rats

Hepatoprotective activities of polyherbal formulations: A systematic review

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