Anticancer effect of green tea extract (GTE)-Loaded pH-responsive niosome Coated with PEG against different cell lines

Baranei, Mahmoud; Taheri, Ramezan Ali; Tirgar, Mahtab; Saeidi, Ardeshir; Oroojalian, Fatemeh; Uzun, Lokman; Asefnejad, Azadeh; Wurm, Frederik R.; Goodarzi, Vahabodin

doi:10.1016/j.mtcomm.2020.101751

Cited by 39 publications

(19 citation statements)

References 76 publications

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“…Baranei et al, 45 when evaluating the cytotoxicity of greentea-loaded particles, observed reductions in the viabilities of different cell lines (MCF-7, HepG2, and HL-60). That research pointed out that compounds such as catechin and some flavonoids present in teas demonstrate inhibitory effects against the growth of cancerous cells.…”

Section: Cytotoxic Assays Using Cell Lines and Anti-inflammatory Activitiesmentioning

confidence: 99%

Bioactivity screening of pinhão (Araucaria Angustifolia (Bertol.) Kuntze) seed extracts: the inhibition of cholinesterases and α-amylases, and cytotoxic and anti-inflammatory activities

et al. 2021

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Section: Cytotoxic Assays Using Cell Lines and Anti-inflammatory Activitiesmentioning

confidence: 99%

Bioactivity screening of pinhão (Araucaria Angustifolia (Bertol.) Kuntze) seed extracts: the inhibition of cholinesterases and α-amylases, and cytotoxic and anti-inflammatory activities

et al. 2021

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“…Extensive use of various excipients, such as binders, thickening agents, sweeteners, and glidants, which can change the physicochemical properties of the final formulation of the drug and adjust the pharmacodynamic and pharmacokinetic properties, has made significant progress in the field of drug delivery systems [1]. Polymers are used as excipients for the progress of polymer-based drug delivery systems with the purpose of targeted drug delivery [2][3][4][5][6][7][8][9]. Synthetic polymers have high physical, chemical, and mechanical stability but can cause cytotoxicity and are bio-incompatible [10].…”

Section: Introductionmentioning

confidence: 99%

Plant-Based Gums and Mucilages Applications in Pharmacology and Nanomedicine: A Review

et al. 2021

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Gums are carbohydrate biomolecules that have the potential to bind water and form gels. Gums are regularly linked with proteins and minerals in their construction. Gums have several forms, such as mucilage gums, seed gums, exudate gums, etc. Plant gums are one of the most important gums because of their bioavailability. Plant-derived gums have been used by humans since ancient times for numerous applications. The main features that make them appropriate for use in different applications are high stabilization, viscosity, adhesive property, emulsification action, and surface-active activity. In many pharmaceutical formulations, plant-based gums and mucilages are the key ingredients due to their bioavailability, widespread accessibility, non-toxicity, and reasonable prices. These compete with many polymeric materials for use as different pharmaceuticals in today’s time and have created a significant achievement from being an excipient to innovative drug carriers. In particular, scientists and pharmacy industries around the world have been drawn to uncover the secret potential of plant-based gums and mucilages through a deeper understanding of their physicochemical characteristics and the development of safety profile information. This innovative unique class of drug products, useful in advanced drug delivery applications, gene therapy, and biosynthesis, has been developed by modification of plant-based gums and mucilages. In this review, both fundamental and novel medicinal aspects of plant-based gums and mucilages, along with their capacity for pharmacology and nanomedicine, were demonstrated.

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“…Recently, transition-metal complexes containing l -ascorbic acid (LAA) and poly(ethylene glycol) (PEG) derivatives have been reported and used in anticarcinoma activity . Cuprous oxide nanoparticles (β-Cu 2 O NPs) of the cuprite phase have gained special interest among transition-metal oxides because of their efficacy as nanofluids, sensors, antimicrobial applications, catalysts, superconductors, energy storage systems, and anticarcinoma agents. , Studies on the interaction of small molecules with proteins are important for the investigation, morphology, and designing of novel drugs effective against anticarcinoma activity . These β-Cu 2 O NPs can bind with proteins via three types of noncovalent interactions like electrostatic binding, metal groove binding, and intercalation binding modes .…”

Section: Introductionmentioning

confidence: 99%

One-Pot Surface Modification of β-Cu₂O NPs for Biocatalytic Performance against A-549 Lung Carcinoma Cell Lines through Docking Analysis

et al. 2021

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The physicochemical approaches and biological principles in bio-nanotechnology favor specially functionalized nanosized particles. Cuprous oxide nanoparticles (β-Cu2O NPs) of cuprite phase with a little tenorite (CuO) may be very effective in the development of novel therapeutic approaches against several fatalities including A-549 lung carcinoma cell lines. Consequently, the synthesis of β-Cu2O NPs for the improvement in the therapeutic index and drug delivery application is becoming an effective strategy in conventional anticarcinoma treatment. Hence, surface-enhanced nanosized spherical cuprous oxide nanoparticles (β-Cu2O NPs) of cuprite phase were successfully prepared using poly(ethylene glycol) (PEG) as an amphiphilic nonionic surfactant and l-ascorbic acid (K3[Cu(Cl5)]@LAA-PEG) reduced to cuprites β-Cu2O NPs via the sonochemical route. Less improved toxicity and better solubility of β-Cu2O NPs compared with Axitinib were a major reason for producing β-Cu2O NPs from K3[Cu(Cl5)]@LAA-PEG (LAA, l-ascorbic acid, PEG, poly(ethylene glycol) (PEG)). These nanoparticle syntheses have been suggested to influence their cytotoxicity, free-radical scavenging analysis, and reactive oxygen species (ROS) using poly(ethylene glycol) (PEG) and l-ascorbic acid (LAA) as coated and grafted materials due to their dose-dependent nature and IC50 calculations. The surface morphology of the formed β-Cu2O NPs has been examined via UV–vis spectroscopy, Fourier transform infrared (FTIR) spectroscopy, scanning electron microscopy with energy diffraction scattering spectroscopy (SEM@EDS), field emission scanning electron microscopy (FESEM), and transmission electron microscopy (TEM) analysis. X-ray diffraction (XRD) and Brunauer–Emmett–Teller (BET) surface analysis results confirm the presence of pure cuprite with a very little amount of tenorite (CuO) phase, Dynamic light scattering (DLS) confirms the negative ζ-value with stable nature. Docking was performed using PDB of lung carcinomas and others, as rigid receptors, whereas the β-Cu2O NP cluster was treated as a flexible ligand.

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Anticancer effect of green tea extract (GTE)-Loaded pH-responsive niosome Coated with PEG against different cell lines

Cited by 39 publications

References 76 publications

Bioactivity screening of pinhão (Araucaria Angustifolia (Bertol.) Kuntze) seed extracts: the inhibition of cholinesterases and α-amylases, and cytotoxic and anti-inflammatory activities

Bioactivity screening of pinhão (Araucaria Angustifolia (Bertol.) Kuntze) seed extracts: the inhibition of cholinesterases and α-amylases, and cytotoxic and anti-inflammatory activities

Plant-Based Gums and Mucilages Applications in Pharmacology and Nanomedicine: A Review

One-Pot Surface Modification of β-Cu₂O NPs for Biocatalytic Performance against A-549 Lung Carcinoma Cell Lines through Docking Analysis

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Anticancer effect of green tea extract (GTE)-Loaded pH-responsive niosome Coated with PEG against different cell lines

Cited by 39 publications

References 76 publications

Bioactivity screening of pinhão (Araucaria Angustifolia (Bertol.) Kuntze) seed extracts: the inhibition of cholinesterases and α-amylases, and cytotoxic and anti-inflammatory activities

Bioactivity screening of pinhão (Araucaria Angustifolia (Bertol.) Kuntze) seed extracts: the inhibition of cholinesterases and α-amylases, and cytotoxic and anti-inflammatory activities

Plant-Based Gums and Mucilages Applications in Pharmacology and Nanomedicine: A Review

One-Pot Surface Modification of β-Cu2O NPs for Biocatalytic Performance against A-549 Lung Carcinoma Cell Lines through Docking Analysis

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Product

Resources

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One-Pot Surface Modification of β-Cu₂O NPs for Biocatalytic Performance against A-549 Lung Carcinoma Cell Lines through Docking Analysis