Anticancer effect of purified polysaccharide from marine clam
            <i>Donax variabilis</i>
            on A549 cells

Sahayanathan, Gracy Jenifer; Padmanaban, Deepakrajasekar; Raja, K.; Chinnasamy, Arulvasu

doi:10.1111/jfbc.13486

Cited by 11 publications

(3 citation statements)

References 20 publications

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“…These high-molecular weight polymers, consisting mainly of carbohydrates, are viewed as exceptional resources for the development of functional foods, biochemical, medicines, cosmetics, and biomaterials [ 10 ]. In particular, polysaccharides have attracted wide attention as medicines due to their broad spectrum of pharmacological functions including anti-oxidative, anti-microbial, anti-inflammatory, anticancer, and hypoglycemic activity [ 11 , 12 , 13 , 14 , 15 ]. Polysaccharides of differing structure show distinct biological functions [ 16 ].…”

Section: Introductionmentioning

confidence: 99%

Purification, Structural Characterization, and Anti-Inflammatory Effects of a Novel Polysaccharide Isolated from Orostachys fimbriata

Fan

Yang

et al. 2021

Molecules

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The present study elucidated the structural characteristics and anti-inflammatory activity of a novel polysaccharide isolated from Orostachys fimbriata, which is a traditional Chinese medicinal plant. O. fimbriata polysaccharide (OFP) was extracted and subsequently purified by chromatography using a DEAE cellulose-52 and Sephadex G-75 column. The molecular weight was determined as 6.2 kDa. HPGPC and monosaccharide composition analysis revealed a homogeneous polysaccharide containing only Glc. Chromatography and spectral analysis showed that the possible chemical structure consisted of →4)-α-Glcp-(1→ and a small quantity of →4,6)-β-Glcp-(1→ in the main chain and →6)-β-Glcp-(1→, α-Glcp-(1→, and β-Glcp-(1→ in the side chain. Morphological analysis using scanning electron microscopy (SEM) and atomic force microscopy (AFM) indicated that OFP had a multi-branched structure, and the sugar chain molecules of polysaccharide appeared aggregated. OFP was found to exhibit anti-inflammatory activity by reducing the secretion of inflammatory factors in RAW264.7 cells and by decreasing the extent of xylene-induced ear swelling in mice.

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Section: Introductionmentioning

confidence: 99%

Purification, Structural Characterization, and Anti-Inflammatory Effects of a Novel Polysaccharide Isolated from Orostachys fimbriata

Fan

Yang

et al. 2021

Molecules

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“…They have the following main targets: DNA polymerases, triglyceridesynthesizing enzymes or microtubules, among others (https://www.marinepharmacology. org/approved (accessed on 4 January 2024)) [95]. Here, we will focus on marina fauna that produce compounds associated with a direct action on mitochondria (summarized in Table 2).…”

Section: The Regulation Of Cell Deathmentioning

confidence: 99%

From Beach to the Bedside: Harnessing Mitochondrial Function in Human Diseases Using New Marine-Derived Strategies

Mirra,

Marfany

2024

IJMS

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Mitochondria are double-membrane organelles within eukaryotic cells that act as cellular power houses owing to their ability to efficiently generate the ATP required to sustain normal cell function. Also, they represent a “hub” for the regulation of a plethora of processes, including cellular homeostasis, metabolism, the defense against oxidative stress, and cell death. Mitochondrial dysfunctions are associated with a wide range of human diseases with complex pathologies, including metabolic diseases, neurodegenerative disorders, and cancer. Therefore, regulating dysfunctional mitochondria represents a pivotal therapeutic opportunity in biomedicine. Marine ecosystems are biologically very diversified and harbor a broad range of organisms, providing both novel bioactive substances and molecules with meaningful biomedical and pharmacological applications. Recently, many mitochondria-targeting marine-derived molecules have been described to regulate mitochondrial biology, thus exerting therapeutic effects by inhibiting mitochondrial abnormalities, both in vitro and in vivo, through different mechanisms of action. Here, we review different strategies that are derived from marine organisms which modulate specific mitochondrial processes or mitochondrial molecular pathways and ultimately aim to find key molecules to treat a wide range of human diseases characterized by impaired mitochondrial function.

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“…Fraction 2.1, a polysaccharide gained from marine clam Donax variabilis , has shown anticarcinoma effects in A549 cells via inducing mitochondria malfunction by enhancing the level of Bax, activity of caspase-3, caspase-9, and stimulating the release of cyt. c while reducing Bcl-2 [ 135 ]. Manzamine A, an alkaloid obtained from sponges of the genera Haliclona sp., Xestospongia sp., and Pellina sp., has been shown to have the ability to destroy HCT116 cells by causing mitochondrial dysfunction by MMP loss, enhance the activity of caspase-3, caspase-7, induce the release of cyt.…”

Section: Marine Compounds Suppress Cancer Through the Modulation Of M...mentioning

confidence: 99%

Marine Compounds, Mitochondria, and Malignancy: A Therapeutic Nexus

et al. 2022

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The marine environment is important yet generally underexplored. It contains new sources of functional constituents that can affect various pathways in food processing, storage, and fortification. Bioactive secondary metabolites produced by marine microorganisms may have significant potential applications for humans. Various components isolated from disparate marine microorganisms, including fungi, microalgae, bacteria, and myxomycetes, showed considerable biological effects, such as anticancer, antioxidant, antiviral, antibacterial, and neuroprotective activities. Growing studies are revealing that potential anticancer effects of marine agents could be achieved through the modulation of several organelles. Mitochondria are known organelles that influence growth, differentiation, and death of cells via influencing the biosynthetic, bioenergetic, and various signaling pathways related to oxidative stress and cellular metabolism. Consequently, mitochondria play an essential role in tumorigenesis and cancer treatments by adapting to alterations in environmental and cellular conditions. The growing interest in marine-derived anticancer agents, combined with the development and progression of novel technology in the extraction and cultures of marine life, led to revelations of new compounds with meaningful pharmacological applications. This is the first critical review on marine-derived anticancer agents that have the potential for targeting mitochondrial function during tumorigenesis. This study aims to provide promising strategies in cancer prevention and treatment.

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Anticancer effect of purified polysaccharide from marine clam Donax variabilis on A549 cells

Cited by 11 publications

References 20 publications

Purification, Structural Characterization, and Anti-Inflammatory Effects of a Novel Polysaccharide Isolated from Orostachys fimbriata

Purification, Structural Characterization, and Anti-Inflammatory Effects of a Novel Polysaccharide Isolated from Orostachys fimbriata

From Beach to the Bedside: Harnessing Mitochondrial Function in Human Diseases Using New Marine-Derived Strategies

Marine Compounds, Mitochondria, and Malignancy: A Therapeutic Nexus

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