Anticancer effects of seaweed compounds fucoxanthin and phloroglucinol, alone and in combination with 5-fluorouracil in colon cells

Lopes-Costa, Eduarda; Abreu, Maria Helena; Gargiulo, Daniela Longo; Rocha, Eduardo; Ramos, Altina

doi:10.1080/15287394.2017.1357297

Cited by 64 publications

(34 citation statements)

References 81 publications

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“…Various known brown algal metabolites have been reported to have anticancer activities. The carotenoid pigment, fucoxanthin shows antiproliferative effects on non small cell lung cancer, 354 and inhibits the growth of colon cancer cells, 355 fucoxanthinol inhibits human colorectal cancer tumorigenicity, 356 tuberatolide B inhibits the growth of breast, lung, colon, prostate and cervical cancers. 357 Fucoxanthin also weakly inhibits monoamine oxidase A and B, prevents H 2 O 2 -induced neuronal apoptosis 358 and is antioxidant and antihypertensive.…”

Section: Brown Algaementioning

confidence: 99%

Marine natural products

et al. 2019

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Section: Brown Algaementioning

confidence: 99%

Marine natural products

et al. 2019

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“…Oral glucose tolerance tests in diabetic mice using these insect GAGs are necessary to ascertain their anti-diabetic effects even though they were not accurate because the orally administered GAGs are also digested and increase the levels of mono (neutral, amino and acid) sugars. In fact, specific functional groups including epoxy, hydroxyl and carbonyl contribute to potent free radicalscavenging activity [26]. In addition to anti-oxidant activities, GbG exhibits unremarkable anti-diabetic activity without adverse effects in in vitro or in vivo models.…”

Section: Discussionmentioning

confidence: 99%

“…In fact, specific functional groups including epoxy, hydroxyl and carbonyl contribute to potent free radical-scavenging activity [ 26 ]. In addition to anti-oxidant activities, GbG exhibits unremarkable anti-diabetic activity without adverse effects in in vitro or in vivo models.…”

Section: Discussionmentioning

confidence: 99%

Anti-diabetic activity of field cricket glycosaminoglycan by ameliorating oxidative stress

Ahn

Kim

et al. 2020

BMC Complement Med Ther

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Background: Field cricket (Gryllus bimaculatus) is newly emerged as an edible insect in several countries. Antiinflammatory effect of glycosaminoglycan derived from this cricket on chronic disease animal model such as diabetic mouse has not been fully investigated yet. Thus, the objective of this study was to determine the antioxidative effect of such glycosaminoglycan on diabetic mouse. Methods: To discover potential therapeutic agents, field cricket glycosaminoglycan (GbG) was tested in the present study. Its anti-oxidative activities in diabetic mice were determined based on its abilities to reduce glucose, ALT, AST, ALP, LDL-cholesterol and BUN levels. Dung beetle (C. molossus) glycosaminoglycan (CaG) was used as a positive control. Db mice were intraperitoneally administered for 1 month according to their group assignments: 1) normal (DB-Hetero); 2) control (DB-Homo); 3) 5 mg/kg treatment of CaG (CaG5); 4) 5 mg/kg treatment of GbG (GbG5); and 5) 10 mg/kg treatment of metformin (Metformin 10). Results: Blood glucose level decreased after 1st week of treatment with GbG. LDL-cholesterol and alkaline phosphatase levels were also inhibited by GbG. Markers of oxidative damage, such as protein carbonyl content and levels of hepatocellular biomarkers, were reduced in db mice treated with GbG. Especially anti-oxidative activities of catalase, superoxide dismutase and glutathione peroxidase were significantly increased in GbG treated group compared to those in the control (Db Homo). GbG was composed of heparin disaccharides. Its main N-glycan was identified as Hex 9 GlcNAc 2 (m/z 1905.7) with neutral mono-sugar mainly comprising of hexose and L (+) rhamnose by mass spectroscopy. Conclusions: Sero-biochemical and hepatocellular anti-oxidant assay results in db mice suggest that cricket (G. bimaculatus) glycosaminoglycan might possess anti-oxidative effect in diabetic state.

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“…All the extracts showed a dose-dependent antiproliferative activity against all the cancer cell lines, although G. corticata had the greatest inhibition activity against MCF-7 cell line (IC 50 value of 30 μg/mL after 24 of treatment). Lopes-Costa et al [ 253 ] reported that phloroglucinol not only reduced the growth of two colorectal cancer cell lines (HCT116 and HT29), but also intensified the activity of 5-fluorouracil, one of the most commonly used chemotherapeutic drugs to treat colorectal cancer. Two polybrominated diphenyl ethers, 3,4,5-tribromo-2-(2’,4’-dibromophenoxy)-phenol and 3,5-dibromo-2-(2’,4’-dibromophe-noxy)-phenol, which were isolated from Dysidea sp., an Indonesian marine sponge, showed antiproliferative activity against PANC-1 cells under glucose-starved conditions.…”

Section: Bioactive Properties Of Marine Phenolicsmentioning

confidence: 99%

Bioactive Properties of Marine Phenolics

2020

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Phenolic compounds from marine organisms are far less studied than those from terrestrial sources since their structural diversity and variability require powerful analytical tools. However, both their biological relevance and potential properties make them an attractive group deserving increasing scientific interest. The use of efficient extraction and, in some cases, purification techniques can provide novel bioactives useful for food, nutraceutical, cosmeceutical and pharmaceutical applications. The bioactivity of marine phenolics is the consequence of their enzyme inhibitory effect and antimicrobial, antiviral, anticancer, antidiabetic, antioxidant, or anti-inflammatory activities. This review presents a survey of the major types of phenolic compounds found in marine sources, as well as their reputed effect in relation to the occurrence of dietary and lifestyle-related diseases, notably type 2 diabetes mellitus, obesity, metabolic syndrome, cancer and Alzheimer’s disease. In addition, the influence of marine phenolics on gut microbiota and other pathologies is also addressed.

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Anticancer effects of seaweed compounds fucoxanthin and phloroglucinol, alone and in combination with 5-fluorouracil in colon cells

Cited by 64 publications

References 81 publications

Marine natural products

Marine natural products

Anti-diabetic activity of field cricket glycosaminoglycan by ameliorating oxidative stress

Bioactive Properties of Marine Phenolics

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