Anticancer therapeutic effect of cerium-based nanoparticles: known and unknown molecular mechanisms

Amaldoss, Maria John Newton; Mehmood, Rashid; Yang, Jialin; Koshy, Pramod; Kumar, Naresh; Unnikrishnan, Ashwin; Sorrell, Charles Christopher

doi:10.1039/d2bm00334a

Cited by 31 publications

(17 citation statements)

References 213 publications

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“…While redox switching is increasingly recognized as playing an important role in ROS-dependent cancer therapy, ROS-independent cytotoxicity mechanisms such as Ce 4+ dissolution and autophagy are also becoming important. Despite the fact that pro-oxidant cancer therapy is the most intensively studied, antioxidant activity, capable of protecting healthy tissues surrounding the tumor, also plays an important role by reducing side effects [ 56 ].…”

Section: Discussionmentioning

confidence: 99%

Mitogen-like Cerium-Based Nanoparticles Protect Schmidtea mediterranea against Severe Doses of X-rays

Filippova

Ермаков²,

Попов³

et al. 2023

IJMS

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Novel radioprotectors are strongly demanded due to their numerous applications in radiobiology and biomedicine, e.g., for facilitating the remedy after cancer radiotherapy. Currently, cerium-containing nanomaterials are regarded as promising inorganic radioprotectors due to their unrivaled antioxidant activity based on their ability to mimic the action of natural redox enzymes like catalase and superoxide dismutase and to neutralize reactive oxygen species (ROS), which are by far the main damaging factors of ionizing radiation. The freshwater planarian flatworms are considered a promising system for testing new radioprotectors, due to the high regenerative potential of these species and an excessive amount of proliferating stem cells (neoblasts) in their bodies. Using planarian Schmidtea mediterranea, we tested CeO2 nanoparticles, well known for their antioxidant activity, along with much less studied CeF3 nanoparticles, for their radioprotective potential. In addition, both CeO2 and CeF3 nanoparticles improve planarian head blastema regeneration after ionizing irradiation by enhancing blastema growth, increasing the number of mitoses and neoblasts’ survival, and modulating the expression of genes responsible for the proliferation and differentiation of neoblasts. The CeO2 nanoparticles’ action stems directly from their redox activity as ROS scavengers, while the CeF3 nanoparticles’ action is mediated by overexpression of “wound-induced genes” and neoblast- and stem cell-regulating genes.

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Section: Discussionmentioning

confidence: 99%

Mitogen-like Cerium-Based Nanoparticles Protect Schmidtea mediterranea against Severe Doses of X-rays

Filippova

Ермаков²,

Попов³

et al. 2023

IJMS

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“…Among all kinds of nanocatalysts, cerium (Ce)-based nanocatalysts are well-known because of their unique redox mechanisms and good biocompatibility, and they have been widely used in many fields. [66][67][68] So far, Cebased nanocatalysts have been found to possess multienzyme activities such as peroxidase (POD), simulate oxidase (OXD), superoxide dismutase (SOD), catalase (CAT), and alkaline phosphatase (AKP). [69][70][71] In particular, many Ce-based nanocatalysts with CAT-like activity have been developed, which have a wide range of applications in biomedical methods.…”

Section: Cerium-basedmentioning

confidence: 99%

Oxygen-generating biocatalytic nanomaterials for tumor hypoxia relief in cancer radiotherapy

Wang

Yao

et al. 2023

J. Mater. Chem. B

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“…The produced nanoceria was successfully internalized without conferring cytotoxicity to melanoma cells [91] 2022 Silver nanoparticles Human metastatic melanoma cell lines A375 and SK-MEL-28 and the murine melanoma cell line B16-F10…”

Section: Murine B16 Melanoma Cellsmentioning

confidence: 99%

Applications of Metallic Nanoparticles in the Skin Cancer Treatment

Marzi

Osanloo

Vakil

et al. 2022

BioMed Research International

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Skin cancer is one of leading cancers globally, divided into two major categories including melanoma and nonmelanoma. Skin cancer is a global concern with an increasing trend, hence novel therapies are essential. The local treatment strategies play a key role in skin cancer therapy. Nanoparticles (NPs) exert potential applications in medicine with huge advantages and have the ability to overcome common chemotherapy problems. Recently, NPs have been used in nanomedicine as promising drug delivery systems. They can enhance the solubility of poorly water-soluble drugs, improve pharmacokinetic properties, modify bioavailability, and reduce drug metabolism. The high-efficient, nontoxic, low-cost, and specific cancer therapy is a promising goal, which can be achieved by the development of nanotechnology. Metallic NPs (MNPs) can act as important platforms. MNPs development seeks to enhance the therapeutic efficiency of medicines through site specificity, prevention of multidrug resistance, and effective delivery of therapeutic factors. MNPs are used as potential arms in the case of cancer recognition, such as Magnetic Resonance Imaging (MRI) and colloidal mediators for magnetic hyperthermia of cancer. The applications of MNPs in the cancer treatment studies are mostly due to their potential to carry a large dose of drug, resulting in a high concentration of anticancer drugs at the target site. Therefore, off-target toxicity and suffering side effects caused by high concentration of the drug in other parts of the body are avoided. MNPs have been applied as drug carriers for the of improvement of skin cancer treatment and drug delivery. The development of MNPs improves the results of many cancer treatments. Different types of NPs, such as inorganic and organic NPs have been investigated in vitro and in vivo for the skin cancer therapy. MNPs advantages mostly include biodegradability, electrostatic charge, good biocompatibility, high drug payload, and low toxicity. However, the use of controlled-release systems stimulated by electromagnetic waves, temperature, pH, and light improves the accumulation in tumor tissues and improves therapeutic outcomes. This study (2019-2022) is aimed at reviewing applications of MNPs in the skin cancer therapy.

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Anticancer therapeutic effect of cerium-based nanoparticles: known and unknown molecular mechanisms

Abstract: Cerium-based nanoparticles (CeNPs), particularly cerium oxide (CeO2), have been studied extensively for their antioxidant and prooxidant properties. However, their complete redox and enzyme-mimetic mechanisms of therapeutic action at the molecular...

Cited by 31 publications

References 213 publications

Mitogen-like Cerium-Based Nanoparticles Protect Schmidtea mediterranea against Severe Doses of X-rays

Mitogen-like Cerium-Based Nanoparticles Protect Schmidtea mediterranea against Severe Doses of X-rays

Oxygen-generating biocatalytic nanomaterials for tumor hypoxia relief in cancer radiotherapy

Applications of Metallic Nanoparticles in the Skin Cancer Treatment

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