Anticarcinogenecity of microbiota and probiotics in breast cancer

Abstract

Breast cancer is one of the most important causes of cancer related morbidity and mortality in the world. Along with genetic, environmental factors also play a multifaceted role in the development of disease. Breast contains several bacterial species performing specialized functions. Probiotics, as functional food, play pivotal role against breast cancer development in vivo and in vitro. Current review summarized all the available data related to diet, probiotics, and their association with breast cancer risk along with underlying mechanisms. Presently, it was believed that many of the commercially available probiotic products were safe to use and had some beneficial health effects for the host. Probiotics had a potential to act against breast cancer progression evidenced by many animal model and cell-based experiments. Some probiotics strains may be useful as an adjuvant therapy for breast cancer prevention or treatment, by modulating immune response or breast microbial community. However, large-scale clinical trials and intense research are mandatory to explore probiotics-related metabolic and molecular mechanisms in breast cancer. ARTICLE HISTORY

Comprehensive profiles and diagnostic value of menopausal-specific gut microbiota in premenopausal breast cancer

“…The antitumor/proliferative effect of Bifidobacterium spp. against breast cancer was also observed in vitro and in vivo 28 , 29 , indicating the loss of tumor-suppressor-like Bifidobacterium spp. in premenopausal breast cancer patients.…”

The Probiotic Bacteria Induce Apoptosis in Breast and Colon Cancer Cells: An Immunostimulatory Effect

“…Moreover, probiotic bacteria can shift Th1 immune responses in infectious and cancer models. Also, the function of innate immune cells, including macrophages, dendritic cells, and natural killer cells is potentiated through these probiotic bacteria which in turn could stimulate adaptive immunity and consequently inhibition of the tumor growth [13,14]. In the present study, anticancer properties of Lactobacillus acidophilus and Bifidobacterium bifidum as two probiotic bacteria were evaluated on HT-29 and MCF7 cancer cell lines.…”

Anti-Gastric Cancer Activity of the Cell-free Culture Supernatant of Serofluid Dish and Lactiplantibacillus plantarum YT013

“…Flow cytometry with Annexin V–PI staining was used to confirm that CCS2 caused apoptosis in a concentration-dependent manner ( Figure 6 ). Studies have proven that the cell-free supernatant of Lacticaseibacillus brevis prevents proliferation and promotes apoptosis in breast cancer ( Malik et al, 2018 ). In another study, found that Lacticaseibacillus casei SR1, SR2, and Lacticaseibacillus paracasei SR4 act against cervical cancer cells via the intrinsic mitochondrial apoptotic pathway inducing apoptosis ( Riaz Rajoka et al, 2018 ).…”