Anticardiolipin and/or anti-β2-glycoprotein-I antibodies are associated with adverse IVF outcomes

Wu, Li; Fang, Xuhui; Lu, Fangting; Wang, Yanshi; Kwak‐Kim, Joanne

doi:10.3389/fimmu.2022.986893

Cited by 10 publications

(4 citation statements)

References 48 publications

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“…Recent studies have demonstrated that an imbalance in Th1/Th2 immune cells plays a crucial role in the pathogenesis of SCH. Cytokines produced by Th1 cells mainly mediate cellular immunity and inflammatory responses that can inhibit embryo implantation, trophoblast growth, embryonic development and fetal survival ( 14 , 15 ). Cytokines secreted by Th2 cells mainly mediate humoral immunity, which maintains pregnancy and antagonizes Th1 type cytokines.…”

Section: Etiology Of Schmentioning

confidence: 99%

Subchorionic hematoma: Research status and pathogenesis (Review)

Xu,

Lun,

2024

Med Int

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Subchorionic hematoma (SCH) is a hematoma in which blood accumulates between the chorion and decidua basalis due to the separation of the chorion and decidua basalis. It is common in patients with threatened abortion in early pregnancy and is mainly detected by ultrasound. SCH mainly manifests as an hypoechoic or anechoic crescent-shaped fluid dark area on ultrasound images. Although there are numerous studies on SCH, its pathogenesis and etiology remain unclear, and its influence on pregnancy outcomes is also controversial; there are also no uniform clinical treatment guidelines. Current studies suggest that the occurrence of SCH may be related to several factors, such as abnormal coagulation function, autoimmune factors of pregnant women, assisted reproduction, drug use during pregnancy and reproductive tract infection; however, its exact etiology remains unclear. Some studies suggest that SCH is associated with adverse pregnancy outcomes such as miscarriage, preterm birth, preeclampsia and fetal growth restriction, although other studies have found that SCH does not increase the risk of adverse pregnancy outcomes. Therefore, the present review mainly discusses the pathogenesis, etiology and treatment of SCH in an aim to provide a reference for the clinical treatment of this condition in pregnant women.

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Section: Etiology Of Schmentioning

confidence: 99%

Subchorionic hematoma: Research status and pathogenesis (Review)

Xu,

Lun,

2024

Med Int

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“…14 aPL might contribute to the process of conception, leading to idiopathic infertility. 65 Nevertheless, aCL and/or aβ2GPI might be associated with adverse in vitro fertilization (IVF) outcomes, 66 with the contribution of platelet-activating factor (PAF). 67 Multiple proposed explanations exist for implantation failure in APS.…”

Section: Female Ovariesmentioning

confidence: 99%

An update on the endocrine manifestations of antiphospholipid syndrome

El Hasbani,

Uthman

2024

Int J of Rheum Dis

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Antiphospholipid Syndrome (APS), characterized by hypercoagulability and pregnancy morbidity, poses a significant clinical challenge when involving organ systems, such as the endocrine system. APS can directly and indirectly influence the anterior and posterior lobes of the pituitary gland. The thyroid gland exhibits involvement, especially in patients with positive anticardiolipin antibodies, yet the clinical significance of the relationship with APS remains elusive. The pancreas, often overlooked, manifests in diverse ways, from pancreatitis to implications in diabetes. Adrenal insufficiency emerges as a common endocrine manifestation of APS, with adrenal hemorrhage or infarction being a presenting manifestation. Adrenal gland involvement has also been reported in the context of catastrophic APS. Pregnancy complications and infertility might be effects of APS on the female ovaries, while testicular torsion and decreased sperm concentration and total sperm count have been reported as rare effects of APS on male testes.

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“…In this case, autoantibodies can be tested. This includes anti-cardiolipin antibodies, lupus anticoagulants, anti-β2-glykoprotein-I antibodies, anti-transglutaminase IgA, and anti-nuclear antibodies, which can be tested [ 199 , 201 ].…”

Section: Clinical Significance In Reproductive Medicinementioning

confidence: 99%

Immune Cell Functionality during Decidualization and Potential Clinical Application

Stope

Mustea

Sänger

et al. 2023

Life

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Due to a vast influx in the secretory phase of the menstrual cycle, leukocytes represent 40–50% of the decidua at the time of implantation. Their importance for the implantation, maintenance of pregnancy, and parturition are known yet not fully understood. Thus, in idiopathic infertility, decidual immune-related factors are speculated to be the cause. In this review, the immune cell functions in the decidua were summarized, and clinical diagnostics, as well as interventions, were discussed. There is a rising number of commercially available diagnostic tools. However, the intervention options are still limited and/or poorly studied. In order for us to make big steps towards the proper use of reproductive immunology findings, we need to understand the mechanisms and especially support translational research.

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Anticardiolipin and/or anti-β2-glycoprotein-I antibodies are associated with adverse IVF outcomes

Cited by 10 publications

References 48 publications

Subchorionic hematoma: Research status and pathogenesis (Review)

Subchorionic hematoma: Research status and pathogenesis (Review)

An update on the endocrine manifestations of antiphospholipid syndrome

Immune Cell Functionality during Decidualization and Potential Clinical Application

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