Anticariogenic and Antimycobacterial Activities of the Essential Oil of Siparuna guianensis Aublet (Siparunaceae)

Melo, Daiana Caetano de; Miranda, Mayker Lázaro Dantas; Júnior, Walnir Gomes Ferreira; Alcoba, Ana Elisa Teixeira; Silva, Thayná de Souza; Cazal, Cristiane de Melo; Martins, Carlos Henrique Gomes

doi:10.17807/orbital.v0i0.930

Cited by 15 publications

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“…Inhibitory effects of essential oils have also been described as consistent with the activity of monoterpenic and sesquiterpenic constituents in cell membranes while damage caused to the membrane is said to yield different effects on diverse microorganisms (Vieira et al 2017). Correlation between the lipophilicity of oil constituents and the antimicrobial activity of essential oils has motivated researchers to investigate the antibacterial activity of some essential oils against cariogenic bacteria (Melo et al 2017, Carneiro et al 2017. In this study, CL-EO and CP-EO were found to display promising activity against S. mutans (MIC = 20 µg/mL) and L. casei (MIC = 31.25 µg/mL) ( Table II).…”

Section: Resultsmentioning

confidence: 92%

“…The high prevalence of tooth decay worldwide has the tooth surface and prevent tooth decay and gum diseases (Melo et al 2017). Chlorhexidine has been widely applied to this purpose because it displays anticariogenic properties.…”

Section: Introductionmentioning

confidence: 99%

“…Chlorhexidine has been widely applied to this purpose because it displays anticariogenic properties. However, its regular use in oral care products often leads to several side effects (Melo et al 2017).…”

Section: Introductionmentioning

confidence: 99%

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Chemical composition and antibacterial activity of essential oils from Citrus aurantifolia leaves and fruit peel against oral pathogenic bacteria

Lemes

Alves

Estevam

et al. 2018

An. Acad. Bras. Ciênc.

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Tooth decay is a major public health problem which affects a large number of people in several countries. Even though more than 700 bacterial species have been detected in the oral cavity, Streptococcus and Lactobacillus stand out as the genera that cause tooth decay and other periodontal diseases. In this study, essential oils from Citrus aurantifolia leaves (CL-EO) and fruit peel (CP-EO) were obtained by hydrodistillation by a Clevenger-type apparatus whereas their chemical composition was analyzed by gas chromatography-flame ionization detector (GC-FID) and gas chromatography-mass spectrometry (GC-MS). Limonene (77.5 %), linalool (20.1 %), citronellal (14.5 %) and citronellol (14.2 %) were the main constituents found in the essential oils from C. aurantifolia leaves and fruit peel. Antibacterial activity of essential oils was evaluated in terms of its minimum inhibitory concentration (MIC) values by the broth microdilution method in 96-well microplates. Both CL-EO and CP-EO displayed some activity against all oral pathogens under investigation; MIC values ranged from 20 to 200 µg/mL. CL-EO and CP-EO not only had promising activity against Streptococcus mutans (MIC = 20 µg/mL) and Lactobacillus casei (31.25 µg/mL), but also displayed antibacterial activity against all studied cariogenic bacteria. Efficacy of essential oils against S. mutans and L. casei is noteworthy and should be further investigated.

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Section: Resultsmentioning

confidence: 92%

Section: Introductionmentioning

confidence: 99%

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Chemical composition and antibacterial activity of essential oils from Citrus aurantifolia leaves and fruit peel against oral pathogenic bacteria

Lemes

Alves

Estevam

et al. 2018

An. Acad. Bras. Ciênc.

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show abstract

“…Tooth decay is an important public health problem that affects a large number of people in many countries in the world. More than 700 species of bacteria are identified in the oral cavity and some of them are responsible for caries and other periodontal diseases, among them we can highlight the bacteria of the genus Streptococcus (Melo et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

Antibacterial and antiproliferative activities of the fresh leaf essential oil of Psidium guajava L. (Myrtaceae)

et al. 2019

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This study evaluated the antibacterial and antiproliferative activities of the essential oil of Psidium guajava leaves (PG-EO), traditionally used in folk medicine. The essential oil was obtained from fresh leaves by hydrodistillation, using a modified Clevenger apparatus. The major PG-EO chemical constituents were identified by GC-MS and GC-FID as being β-caryophyllene (16.1%), α-humulene (11.9%), aromadendrene oxide (14.7%), δ-selinene (13.6%), and selin-11-en-4α-ol (12.5%). The antibacterial activity of the essential oil of P. guajava leaves was determined in terms of its minimum inhibitory concentrations (MIC) using the broth microdilution method in 96-well microplates. PG-EO had moderate activity against Streptococcus mutans (MIC = 200 µg/mL), S. mitis (MIC = 200 µg/mL), S. sanguinis (MIC = 400 µg/mL), S. sobrinus (MIC = 100 µg/mL), and S. salivarius (MIC = 200 µg/mL). The antiproliferative activity was evaluated against different tumor cell lines: breast adenocarcinoma (MCF-7), human cervical adenocarcinoma (HeLa), and human gliobastoma (M059J). A normal human cell line (GM07492A, lung fibroblasts) was included. The antiproliferative activity was evaluated using the XTT assay and the results were expressed as IC50. The essential oil showed significantly lower IC50 values against MCF-7 and M059J lines than that obtained for the normal line, showing selectivity. Our results suggest that the essential oil of Psidium guajava L. has promising biological activities and can be considered a new source of bioactive compounds.

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“…Neste sentido, a ampla biodiversidade de compostos bioativos presentes em óleos essenciais extraídos de plantas têm despertado cada vez mais o interesse dos pesquisadores do mundo inteiro. 5 Estes óleos essenciais podem ser obtidos de diferentes espécies de plantas e possuem várias atividades biológicas, tais como: antibacteriana, anticancerígena, antiinflamatória, antimutagênica, antifúngica, antioxidante e antiprotozoária. 6 A espécie Eugenia klotzschiana é conhecida popularmente como Pêra-do-Cerrado e possui distribuição geográfica restrita sendo atualmente bastante empregada para prática vegetativa de controle da erosão dos solos.…”

Section: Introductionunclassified

Essential Oil of Flowers from Eugenia klotzschiana (Myrtaceae): Chemical Composition and In Vitro Trypanocidal and Cytotoxic Activities

Miranda

Alves

et al. 2017

Rev. Virtual Quim.

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Chagas disease, which is caused by Trypanosoma cruzi, has been commonly treated by nifurtimox and benzonidazole, two drugs that cause several side effects. As a result, the use of natural products for treating neglected diseases has increased in recent years and plants have become a promising alternative to developing new medicines. Therefore, this study aimed to determine the chemical composition of the essential oil from fresh flowers of Eugenia klotzchiana and to evaluate for the first time its trypanocidal and cytotoxic potential in vitro. The essential oil from the fresh flowers was obtained by hydrodistillation carried out by a Clevenger apparatus and its chemical composition was determined by GC-MS. The main compounds found in the essential oil were ses uite pe oids: β-caryophyllene (21.1%), bicyclogermacrene (10.2%) and spathulenol (20.9%). Results showed that the essential oil had strong trypanocidal activity against the trypomastigote forms of Trypanosoma cruzi (IC 50 =. μg/ L a d ode ate toto i it agai st fi o lasts i the o e t atio a ge CC 50 =. μg/ L. I sho t, the essential oil from fresh flowers of Eugenia klotzchiana can be considered a new source of bioactive compounds for the development of antiparasitic drugs.

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Anticariogenic and Antimycobacterial Activities of the Essential Oil of Siparuna guianensis Aublet (Siparunaceae)

Cited by 15 publications

References 0 publications

Chemical composition and antibacterial activity of essential oils from Citrus aurantifolia leaves and fruit peel against oral pathogenic bacteria

Chemical composition and antibacterial activity of essential oils from Citrus aurantifolia leaves and fruit peel against oral pathogenic bacteria

Antibacterial and antiproliferative activities of the fresh leaf essential oil of Psidium guajava L. (Myrtaceae)

Essential Oil of Flowers from Eugenia klotzschiana (Myrtaceae): Chemical Composition and In Vitro Trypanocidal and Cytotoxic Activities

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