Anticholinesterase, Antidiabetic and Anti-inflammatory Activity of Secondary Metabolites of Teucrium Species

Zlatić, Nenad; Stanković, Milan

doi:10.1007/978-3-030-52159-2_14

Cited by 5 publications

(5 citation statements)

References 74 publications

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“…The investigation only employed analyticalgrade solvents and materials. The experiment was conducted with deionized, double-distilled water (Zlatić and Stanković, 2020).…”

Section: Methodsmentioning

confidence: 99%

Fabrication of microspheres and characterization of antimicrobial and anti-inflammatory activity isolated fraction from total alcoholic extract of Cassia Fistula (Linn.) in carrageenan-Type-IV induced inflammatory rats

Bee,

Jat,

Ahmad

2023

IJERR

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The Cassia fistula Linn is known as the golden shower tree. It’s also referred to as a "disease killer" in Ayurvedic medicine. The current study investigates the effect and estimate of antimicrobial and Anti-inflammatory activity guided fraction isolated from alcoholic extract of Cassia fistula (Linn.) root on carrageenan-Type IV induced Inflammatory rats for using Column fraction of alcoholic extract of root of Cassia fistula (Linn.) An in vivo carrageenan-induced paw edoema model was used to confirm further the anti-inflammatory effect of the fraction aloe-emodin and physcion-loaded microspheres. This study was designed first time for the isolation of alcoholic fraction of aloe emodin and Physcion by root extract and screening of pharmacological activities of Cassia fistula. Aloe-emodin and Physcion fraction demonstrated antibacterial and antifungal effectiveness against the studied pathogens in a dose-dependent manner, according to anti-microbial activity. 50 mg/ml concentration of Physcion-containing microspheres and aloe emodin's antibacterial efficacy against tested pathogens. The anti-inflammatory activity of Aloe emodin and Physcion was found in an equal manner. Both Microsphere samples were found capable of controlling the inflammation till 6 hours. According to the findings of this research, the chosen plant extracts have an immediate anti-inflammatory effect. There are three stages during which carrageenan-induced inflammation mediators are released.

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“…The investigation only employed analyticalgrade solvents and materials. The experiment was conducted with deionized, double-distilled water (Zlatić and Stanković, 2020).…”

Section: Methodsmentioning

confidence: 99%

Fabrication of microspheres and characterization of antimicrobial and anti-inflammatory activity isolated fraction from total alcoholic extract of Cassia Fistula (Linn.) in carrageenan-Type-IV induced inflammatory rats

Bee,

Jat,

Ahmad

2023

IJERR

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“…The family includes 236 genera, of which the genus Teucrium has 250 species worldwide, especially in the Mediterranean region [3]. Teucrium species have been used for centuries in folk medicine for their cholagogue, diuretic, antispasmodic, antidiabetic, antirheumatic, anti-inflammatory, antiseptic and vermicidal properties [4]. They are used against flatulence, as aromatics, as antipyretics, and as stimulants.…”

Section: Introductionmentioning

confidence: 99%

Phytochemical Profile, Antioxidant Activity and Cholinesterase Inhibition Potential of Essential Oil and Extracts of Teucrium montanum from Bosnia and Herzegovina

et al. 2023

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Bioactive compounds from plants play an important role in slowing many neurodegenerative diseases, such as Alzheimer’s disease, by inhibiting cholinesterase enzymes. Studies have shown that oxidative stress is associated with the development of Alzheimer’s disease. In traditional medicine of Bosnia and Herzegovina, Teucrium montanum is used to treat numerous diseases. The chemical composition and biological activity of the essential oil (EO) and aqueous (AE) and methanol extract (ME) of this plant were studied. The chemical composition of EO was studied using GC-MS, while the composition of the extracts was studied using HPLC-DAD. Antioxidant activity was tested using the DPPH and FRAP methods. The protection of lipids and proteins from oxidation was tested using the ammonium thiocyanate and BSA oxidation methods. The ability to inhibit cholinesterases was tested by the Ellman method. The main identified EO compounds were α-cadinol, ß-selinene, δ-cadinene, epi-α-cadinol, germacrene D-4-ol, and α-pinene. The main phenolic compounds of the extracts were p-coumaric acid, ellagic acid and caffeic acid. The tested extracts showed good antioxidant radical scavenging and reducing potential and a very good ability to protect lipids and proteins from oxidation. The EO showed moderate AChE and BChE inhibition potential, while the extracts showed weak or no ability.

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“…Many species of the genus Teucrium possess several biological activities. Some of the properties are antinociceptive, antihypertensive, anticancer, anti-inflammatory, hypoglycemic, antioxidant, and antibacterial [6][7][8][9]. Moreover, plant species from this genus are used in traditional medicine for their diaphoretic, tonic, antipyretic, antispasmodic, and cholagogue purposes [10].…”

Section: Introductionmentioning

confidence: 99%

Chemical Composition and Antioxidant Activity of Essential Oil from the Aerial Parts of Teucrium luteum (Mill.) Degen subsp. flavovirens (Batt.) Greuter & Burdet Growing Wild in Tunisia

et al. 2022

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Essential oils (EOs), the odorous and volatile products of a plant’s secondary metabolism, have wide applications in folk medicine, in food flavoring and preservation, and in fragrance industries. The aim of this study was to analyze the chemical composition of the EO from the aerial parts (including the inflorescences) of wild Teucrium luteum subsp. flavovirens from Tunisia. The EO obtained by the hydrodistillation of air-dried plant material in a Clevenger-type apparatus was analyzed using gas chromatography coupled with mass spectrometry (GC-MS). Fifty-three components representing 83.9% of the total constituents were identified. The EO of T. luteum subsp. flavovirens is characterized by the presence of β-elemol (7.2%), (+)-α-pinene (6%), β-eudesmol (5.5%), guaiol (4.2%), α-bisabolol (4.2%), and β-caryophyllene (4.1%) as principal chemical components. In vitro (DPPH and β-carotene bleaching assays), it showed significantly higher radical scavenging and antioxidant properties than the reference compound, BHT. To the best of our knowledge, this is the first report describing the composition and antioxidant properties of the EO from Tunisian T. luteum subsp. flavovirens. Our preliminary data will help to valorize this potentially useful plant species from Tunisia and represent a starting point for further studies on its volatile fraction.

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Anticholinesterase, Antidiabetic and Anti-inflammatory Activity of Secondary Metabolites of Teucrium Species

Cited by 5 publications

References 74 publications

Fabrication of microspheres and characterization of antimicrobial and anti-inflammatory activity isolated fraction from total alcoholic extract of Cassia Fistula (Linn.) in carrageenan-Type-IV induced inflammatory rats

Fabrication of microspheres and characterization of antimicrobial and anti-inflammatory activity isolated fraction from total alcoholic extract of Cassia Fistula (Linn.) in carrageenan-Type-IV induced inflammatory rats

Phytochemical Profile, Antioxidant Activity and Cholinesterase Inhibition Potential of Essential Oil and Extracts of Teucrium montanum from Bosnia and Herzegovina

Chemical Composition and Antioxidant Activity of Essential Oil from the Aerial Parts of Teucrium luteum (Mill.) Degen subsp. flavovirens (Batt.) Greuter & Burdet Growing Wild in Tunisia

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