Anticoagulant activity, paw edema and pleurisy induced carrageenan: Action of major types of commercial carrageenans

Silva, F.R.F.; Dore, Celina Maria Pinto Guerra; Marques, Cybelle Teixeira; Nascimento, Marília S.; Benevídes, Norma Maria Barros; Rocha, Hugo Alexandre Oliveira; Chavante, Suely F.; Leite, Edda Lisboa

doi:10.1016/j.carbpol.2009.07.010

Cited by 192 publications

(129 citation statements)

References 22 publications

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“…A estrutura da CAR de S. filiformis é preponderantemente do tipo iota, sendo assim destituída de um grupamento sulfato que esterifica no carbono 6 da unidade B da cadeia principal, formando, assim, a ligação 3,6-anidrogalactose. Essa característica permite a formação de géis e espessantes como propriedades importantes nas indústrias de alimentos (HOLANDA, 2007;CAMPO et al, 2009) e farmacêutica, por exemplo, induzindo, neste último caso, processos inflamatórios que objetivem a avaliação de drogas antiinflamatórias em experimentos de inflamação e dor inflamatória (SILVA et al, 2010). No entanto, a perda do radical sulfato comparada a sua forma precursora (nucarragenana) sugere a baixa atividade dos Tabela 1-Atividade anticoagulante de iota-carragenanas, obtidas por cromatografia de troca iônica (DEAE-celulose) da rodofícea cultivada Solieria filiformis em relação à heparina.…”

Section: Resultsunclassified

“…A densidade de grupos sulfatados na estrutura química, bem como a composição monossacarídica, a ocorrência de unidades disulfatadas e o peso molecular também devem ser considerados como pré-requisitos de ação anticoagulante (MOURÃO, 2004;ZHANG et al, 2008;SILVA et al, 2010). Estudos adicionais, para averiguar a influência dos fatores climáticos e ambientais sobre a biossíntese e a atividade biológica desses polímeros, já estão sendo conduzidos por nosso grupo de pesquisa.…”

Section: Resultsunclassified

“…PS de algas marinhas vermelhas ocorrem na forma de galactanas sulfatadas (PEREIRA et al, 2005;SILVA et al, 2010), de fucanas sulfatadas nas algas pardas (MOURÃO, 2004;AZEVEDO et al, 2009) e, nas algas verdes, os mais encontrados são as arabino-galactanas e as raminoses (GHOSH et al, 2004;ZHANG et al, 2008).…”

Section: Introductionunclassified

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Isolamento, fracionamento e atividade anticoagulante de iota-carragenanas da Solieria filiformis

et al. 2010

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RESUMO Este estudo teve como objetivo isolar, fracionar e avaliar o potencial anticoagulante de iota-carragenanas (iCARs) da rodofícea Solieria filiformis, quando obtidas por dois métodos de extração (M I e M II). As i-CARs foram isoladas ABSTRACT This study aimed to isolate, fractionate and evaluate the anticoagulant potential of iota-carrageenans (i-CARs) from Solieria filiformis when two extraction methods (M I and M II) were used. i-CARs were isolated with papain in 0.1M sodium acetate (pH 5.0) containing 5mM cystein and 5mM EDTA (M I) or water (80°C) (M II), and then their chemical composition of total carbohydrates, free sulfate (FS) and contaminant proteins were determined. i-CARs were submitted to anionexchange chromatography (DEAE-cellulose) using a sodium chloride gradient,being evaluated the activated partial thromboplastin time (APTT) and prothrombin time of obtained fractions and compared to heparin (

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Section: Resultsunclassified

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Isolamento, fracionamento e atividade anticoagulante de iota-carragenanas da Solieria filiformis

et al. 2010

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“…Sulfated polysaccharides (SPs) make up a group of biopolymers that occur in a great variety of marine organisms (Stephen, 1995;Hayashi et al, 1996;Mourão and Pereira, 1999;Aquino et al, 2005;Pomin and Mourão, 2008;Robic et al, 2009;Rodrigues et al, 2009a;Mestechkina and Shcherbukhin, 2010;Rodrigues et al, 2010). In red seaweed, SPs are known as sulfated galactans, and are found in carrageenans and agarans (Melo et al, 2002;Marinho-Soriano, 2006;Pomin and Mourão, 2008;Campo et al, 2009;Silva et al, 2010;Rodrigues et al, 2011a). These highly charged macromolecules (presence of sulfate groups) exhibit chemical structures of complex and heterogeneous nature, playing an important role in ionic, mechanical and osmotic functions, and are constituents of the extracellular matrix of marine algae (Kloareg and Quatrano, 1988).…”

Section: Introductionmentioning

confidence: 99%

Effect of a crude sulfated polysaccharide from Halymenia floresia (Rhodophyta) on gastrointestinal smooth muscle contractility

Graça

Bezerra

Lima

et al. 2011

Braz. arch. biol. technol.

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“…Large molecular size of κ-carrageenan have limited applications as it is insoluble in water and it forms viscous solution. Converting the High Molecular Weight Fraction of carrageenan (HMWF) into Low Molecular Weight of carrageenan (LMWF) will construct the bioavailability and enlarge the potential uses of carrageenan in pharmaceutical and biomedical [5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21].…”

Section: Introductionmentioning

confidence: 99%

Chemical and Spectral Characterization of The Ozonation Products of κ-Carrageenan

et al. 2018

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Abstract. Kappa (κ-) carrageenan oligomers are known to have several biological activities. Recent progress in the development of modified κ-carrageenan has resulted low molecular of κ-carrageenan. Ozone is a powerful oxidant and considered for depolymerization of κ-carrageenan. However, few studies have investigated the changes in κ-carrageenan properties associated with ozone treatment. This study would investigate on the changes in chemical structure after ozonation process. The experiments were carried out in a glass reactor equipped with an ozone bubble diffuser. Ozone with concentration of 80 ± 2 was bubbled into the solution. The ozone treatment was conducted at different times, i.e., 0 (control), 5, 10, 15, and 20 minutes. The experiments were conducted at pH 7 and constant stirring speed (200 rpm). Ozone-treated κ-carrageenan was dried at 60 o C for 24 h in a forced air oven. The chemical and spectral analyses of κ-carrageenan after ozonation process were carried out using UV-Vis and FT-IR spectroscopy. These changes are seen in the UV spectra as a high intensity of absorbance peak at 290 nm. It is shows that ozonation of κ-carrageenan leads to some chemical changes such as the formation of carbonyl, carboxyl or double bonds.The FT-IR spectra reveals that the chemical structure of degraded κ-carrageenan, in term of sulfate content, is only slightly affected by the ozone treatment.

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Anticoagulant activity, paw edema and pleurisy induced carrageenan: Action of major types of commercial carrageenans

Cited by 192 publications

References 22 publications

Isolamento, fracionamento e atividade anticoagulante de iota-carragenanas da Solieria filiformis

Isolamento, fracionamento e atividade anticoagulante de iota-carragenanas da Solieria filiformis

Effect of a crude sulfated polysaccharide from Halymenia floresia (Rhodophyta) on gastrointestinal smooth muscle contractility

Chemical and Spectral Characterization of The Ozonation Products of κ-Carrageenan

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