Anticoagulant properties of a sulfated galactan preparation from a marine green alga, Codium cylindricum

Matsubara, Kiminori; Matsuura, Yasushi; Bacic, Antony; Liao, Ming-Long; Hori, Kazuaki; Miyazawa, Keiji

doi:10.1016/s0141-8130(01)00137-4

Cited by 179 publications

(102 citation statements)

References 17 publications

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“…In recently years, diverse biological activities have been focused for algae SPs (Nishino et al, 1991;Farias et al, 2000;Matsubara et al, 2001;Mourão, 2004;Talarico et al, 2004;Pereira et al, 2005;Pushpamali et al, 2008;Rodrigues et al, 2009b;Rodrigues et al, 2010;Rodrigues et al, 2011a). These studies suggested that was interesting to investigate this class of macromolecules in animal models (Mourão and Pereira, 1999;Farias et al, 2001;Zhang et al, 2003;Assreuy et al, 2008;Fonseca et al, 2008;Lins et al, 2009;Ananthi et al, 2010), as valuable tools on development of new pharmacological drugs.…”

Section: Biological Assaysmentioning

confidence: 99%

“…Nevertheless, the adverse effect level of SPs depend the administered dose (Li et al, 2005). In recent years, SPs have been extensively studied as anticoagulant and antithrombotic agents (Farias et al, 2000;Matsubara et al, 2001;Mourão, 2004;Pereira et al, 2005;Pushpamali et al, 2008;Azevedo et al, 2009;Rodrigues et al, 2009a;Rodrigues et al, 2009b;Rodrigues et al, 2010;Mestechkina and Shcherbukhin, 2010;Rodrigues et al, 2011a). Their biological actions suggest that each SP may be dependent of a structural requirement (Mourão and Pereira, 1999;Pereira et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

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Effect of a crude sulfated polysaccharide from Halymenia floresia (Rhodophyta) on gastrointestinal smooth muscle contractility

Graça

Bezerra

Lima

et al. 2011

Braz. arch. biol. technol.

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Section: Biological Assaysmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effect of a crude sulfated polysaccharide from Halymenia floresia (Rhodophyta) on gastrointestinal smooth muscle contractility

Graça

Bezerra

Lima

et al. 2011

Braz. arch. biol. technol.

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“…10) Fucoidan from Fucus vesiculosus is composed of 44.1% fucose, 26.3% sulfate and ash, and a little amino-glucose. 11) It has been reported that fucoidan had various pharmacological properties such as an anti-coagulant, 12) anti-tumor, 13) anti-inflammatory, 14) and anti-oxidant, 15) and promoted the immune function. 16) Fucoidan also protected tissues from various types of injury by increasing the hepatic growth factor (HGF).…”

mentioning

confidence: 99%

Suppression by Fucoidan of Liver Fibrogenesisviathe TGF-β/Smad Pathway in Protecting against Oxidative Stress

Hong

Jung

Lee

et al. 2011

Bioscience, Biotechnology, and Biochemistry

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“…Arumugam et al 34 , had quantified the heparin yield as 2.27 g/kg and 2.2 g/kg from Tridacna maxima and Perna viridis respectively. Matsubara et al 35 reported an anticoagulant isolated from the green alga Codium cylindricum on thrombin activity in the absence of anti thrombin III and heparin cofactor II using chromogenic substrate. The result of the present study clearly showed average yield of heparin and heparin-like glycoasaminoglycans compared to existing reports.…”

Section: Discussionmentioning

confidence: 99%

Anticoagulant Potential of Marine Polychaete (Nereis Species)

Singh¹,

Sahu²,

Thangaraj³

et al. 2013

J Biol Sci Opin

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There has been an accelerated rate of mortality and morbidity stemming from various chronic diseases worldwide over recent years. Anticoagulants play a pivotal role as agents for the prevention and treatment of thromboembolic disorder. Glycosaminoglycans (GAGs) are linear polysaccharides found in the extracellular matrix and biological fluids of animals where they interact with hundreds of proteins and perform a variety of critical roles. The present study reports the isolation and characterization of glycosaminoglycans from marine polychaete (Nereis sp). The isolated glycosaminoglycans were quantified as 12 g/kg and 0.83 mg/kg from the crude and purified samples respectively. Polychaete showed the anticoagulant activity of the 58 USP units/mg from crude; whereas purified samples showed 114 USP units/mg. The structural characterization of anticoagulant INTRODUCTIONAn anticoagulant is a substance that prevents coagulation; that is, it stops blood from clotting 1 . There has been an accelerated rate of mortality and morbidity stemming from various chronic diseases worldwide over recent years. In view of this, the contribution of vascular coagulopathies to the alarming number of deaths yearly cannot be overlooked because thrombosis was identified as one of the leading causes of myocardial infarction, stroke and pulmonary embolism 2 . Hence, anticoagulants play a pivotal role as agents for the prevention and treatment of thromboembolic disorder 3,4 . For more than five decades, anticoagulant drugs consisting of heparins, vitamin K-antagonists, and their derivatives have been the major players in the clinical setting. Although their efficacy remains undisputed, the deleterious life-threatening side effects of these drugs have also been well documented 5,6 . At present, lavish focus is being given to potent anticoagulant sources hailing from natural origin. In this regard, marine organisms could be of immense interest as they are living in a very exigent, competitive and aggressive surrounding different in many facets from the terrestrial environment, a situation that demands the production of quite unique and potent active molecules 7 . Heparin is a compound that has been widely used as an anticoagulant and antithrombotic agent for more than 50 years. This drug is also employed during extracorporeal circulation 8 . However, several adverse effects of heparin have been identified, such as the development of thrombocytopenia, hemorrhage and low platelet count 9 . Thus, new compounds with similar properties to heparin are needed, and the sulfated polysaccharides of marine resources, which have important anticoagulant and anti-thrombotic actions, are an attractive alternative 10 . There are five classes of animal Glycosaminoglycans (GAGs): heparan sulfate (HS), chondroitin sulfate (CS), dermatan sulfate (DS), keratan sulfate (KS), and hyaluronan (HA). Many biological functions can be monitored directly by their impact on GAG quantity. Heparin has been used for anticoagulant therapy for many years. Its anticoagul...

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Anticoagulant properties of a sulfated galactan preparation from a marine green alga, Codium cylindricum

Cited by 179 publications

References 17 publications

Effect of a crude sulfated polysaccharide from Halymenia floresia (Rhodophyta) on gastrointestinal smooth muscle contractility

Effect of a crude sulfated polysaccharide from Halymenia floresia (Rhodophyta) on gastrointestinal smooth muscle contractility

Suppression by Fucoidan of Liver Fibrogenesisviathe TGF-β/Smad Pathway in Protecting against Oxidative Stress

Anticoagulant Potential of Marine Polychaete (Nereis Species)

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