Anticoccidial evaluation of halofuginone, lasalocid, maduramicin, monensin and salinomycin

Folz, S.D.; Lee, B.L.; Nowakowski, Łukasz; Conder, George A.

doi:10.1016/0304-4017(88)90013-1

Cited by 40 publications

(12 citation statements)

References 8 publications

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“…Recently the most powerful drugs in veterinary medicine effective against coccidiosis and infections induced by Gram-positive organisms represent the group of naturally occurring polyether ionophorous antibiotics (Agtarap et al 1967;Stern 1977;Berg and Hamill 1978;Liu et al 1978;Chappe 1979;Long and Jeffers 1982;Westley et al 1983;Augustine et al 1987;Koinarski and Sherkov 1987;Folz et al 1988;Augustine et al 1992;Varga and Sreter 1996;Wang et al 2006;Kevin et al 2009). Their main representative-monensin-is well known and its ability of binding monovalent metal ions is extensively studied.…”

Section: Introductionmentioning

confidence: 98%

First solid state alkaline-earth complexes of monensic acid A (MonH): crystal structure of [M(Mon)2(H2O)2] (M = Mg, Ca), spectral properties and cytotoxicity against aerobic Gram-positive bacteria

Pantcheva¹,

Zhorova²,

Mitewa³

et al. 2009

Biometals

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Alkaline-earth metal complexes of the monoanionic form of the polyether ionophore monensin A were isolated for the first time in solid state and were structurally characterized using various spectroscopic methods (IR, NMR, FAB-MS). The stoichiometric reaction of monensic acid (MonH) with M(2+) (M = Mg, Ca) in the presence of an organic base leads to the formation of mononuclear complexes of composition [M(Mon)(2)(H(2)O)(2)]. The structures of magnesium (1) and calcium (2) monensin complexes in the solid state were established by single crystal X-ray crystallography. The complexes crystallize as [Mg(Mon)(2)(H(2)O)(2)]x5MeCN (1) and [Ca(Mon)(2)(H(2)O)(2)]xH(2)Ox5MeCN (2) in the monoclinic P21 space group. The alkaline-earth metal ion is placed in a distorted octahedral environment, defined by two monensin anions acting as bidentate ligands in the equatorial plane of the complex as well as by two water molecules occupying the axial positions of the inner coordination sphere. The bactericidal activity of 1 and 2 was evaluated against aerobic Gram-positive microorganisms applying the double layer agar hole diffusion method.

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Section: Introductionmentioning

confidence: 98%

First solid state alkaline-earth complexes of monensic acid A (MonH): crystal structure of [M(Mon)2(H2O)2] (M = Mg, Ca), spectral properties and cytotoxicity against aerobic Gram-positive bacteria

Pantcheva¹,

Zhorova²,

Mitewa³

et al. 2009

Biometals

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show abstract

Section: Introductionmentioning

confidence: 98%

“…1) is a polyether ionophore antibiotic, which was produced by Actinomadura yumaensis and discovered in the early 1980s (Folz et al 1988). It has a very board spectrum of anticoccidial activity and has been widely used to control coccidiosis in poultry (Folz et al 1988;McDougald et al 1990) and improve feed utilization (Gliddon et al 1988). Due to the great toxicity and narrow margin of safety, poisoning can often occur in chickens when they were fed MD above the recommended level (Donev, Vladimirova, and Kodjuharov 1997;Singh and Gupta 2003), and the residue of MD in chicken tissues is also potentially hazardous to human health (Sharma et al 2005).…”

Section: Introductionmentioning

confidence: 98%

Monoclonal Antibody-Based Immunoassay for the Detection of Maduramicin in Chicken Tissues

et al. 2009

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This paper reports on the preparation of a monoclonal antibody (Mab) against maduramicin (MD) and the development of a simple and sensitive ELISA for MD in chicken tissues. MD was conjugated to bovine serum albumin for immunogens and ovalbumin for coating antigens by mixed anhydride (MA) and active ester (AE) methods. Hybridoma cells were generated using spleen cells from a mouse immunized with MD-BSA conjugate. After screening with ELISA, the Mab with high anti-interference ability and high affinity was selected, and it exhibited negligible cross-reactivity with other usual-used polyether antibiotics. After optimization, the developed ELISA showed an IC 50 value of 2.12 AE 0.46 ng=ml (n ¼ 20). Chicken muscle and liver samples were extracted with methanol-8% NaCl solution (4:1) and then directly diluted with PBS-10% methanol for analysis. The recoveries of MD from spiked chicken tissues at levels of 40-480 mg=kg ranged from 81.3% to 91.3% with variation coefficients of

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“…Since its discovery by Agtarap et al (1), the natural polyether ionophorous antibiotic monensin still attracts attention due to its strong coccidiostatic and antibacterial properties (1,6,11,16,31,34). Recently the interest to its biological activity has been raised significantly by the data concerning its ability to decrease the viability and proliferation of cell lines established from malignancies such as leukemia, lymphoma, myeloma, renal cell carcinoma, cancers of the colon, breast, uterine cervix, etc.…”

Section: Introductionmentioning

confidence: 99%

In VitroActivity of Biometal(II) Complexes of Monensin Against Virus-Induced Transplantable Animal Tumors

Pantcheva

Alexandrova

Zhivkova

et al. 2013

Biotechnology & Biotechnological Equipment

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Anticoccidial evaluation of halofuginone, lasalocid, maduramicin, monensin and salinomycin

Cited by 40 publications

References 8 publications

First solid state alkaline-earth complexes of monensic acid A (MonH): crystal structure of [M(Mon)2(H2O)2] (M = Mg, Ca), spectral properties and cytotoxicity against aerobic Gram-positive bacteria

First solid state alkaline-earth complexes of monensic acid A (MonH): crystal structure of [M(Mon)2(H2O)2] (M = Mg, Ca), spectral properties and cytotoxicity against aerobic Gram-positive bacteria

Monoclonal Antibody-Based Immunoassay for the Detection of Maduramicin in Chicken Tissues

In VitroActivity of Biometal(II) Complexes of Monensin Against Virus-Induced Transplantable Animal Tumors

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