Anticomplementary activity of ginseng saponins and their degradation products

Park

Biological & Pharmaceutical Bulletin

et al. 2004

Self Cite

101

In order to determine on the anti-complement activity of triterpenes, following eleven triterpenoides were isolated from the fruits of the Zizyphus jujuba MILL: ceanothane-type triterpenes: colubrinic acid (1), zizyberenalic acid (11); lupane-type triterpenes: alphitolic acid (2), 3-O-cis-p-coumaroyl alphitolic acid (3), 3-O-trans-pcoumaroyl alphitolic acid (4), betulinic acid (7), betulonic acid (9); and oleanane-type triterpenes: 3-O-cis-pcoumaroyl maslinic acid (5), 3-O-trans-p-coumaroyl maslinic acid (6), oleanolic acid (8), oleanonic acid (10). These compounds were examined for their anti-complement activity against the classical pathway of the complement system. Among them, compounds 5, 6, and 8 exhibited significant anti-complement activity with IC 50 values of 101.4, 143.9, and 163.4 m mM, respectively, whereas the ceanothane-type and the lupane-type triterpenes were inactive. This suggests that the oleanane-structure plays an important role in inhibiting the hemolytic activity of human serum against erythrocytes.

Section: Resultsmentioning

confidence: 99%

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confidence: 99%

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confidence: 99%

See 1 more Smart Citation

Anti-complementary Activity of Triterpenoides from Fruits of Zizyphus jujuba

Park

Biological & Pharmaceutical Bulletin

et al. 2004

Self Cite

101

“…Therefore, an agent which has modulatory effects on complement activation can be one of the alternative treatments for inflammatory diseases, and so far, great effort has been given to finding anti-complement components from natural sources. [3][4][5][6][7][8] A number of plant derived polysaccharides and phenolic compounds have been reported to show immunomodulatory effects including anti-complement activity. Especially, there is evidence about the beneficial effects on anti-inflammatory or immunomodulatory activity of red ginseng, one of the most popular herbal drugs, which is partly explained by the anti-complementary activity of ginsenosides.…”

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confidence: 99%

“…Especially, there is evidence about the beneficial effects on anti-inflammatory or immunomodulatory activity of red ginseng, one of the most popular herbal drugs, which is partly explained by the anti-complementary activity of ginsenosides. 3,4) Kim et al has examined on the anti-complementary activity of ginsenosides isolated from red ginseng, among which red ginseng's unique ginsenosides such as Rg 6 , Rh 4 were revealed to be inhibitive on the complement activation, 4) though their contents in red ginseng were extremely low. Processed ginseng prepared under optimized condition contains maximized amounts of red ginseng's unique ginsenosides including novel types of ginsenosides which were revealed to have enhanced biological activity, 9,10) however their anticomplementary effect was still not yet elucidated.…”

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confidence: 99%

Anti-complementary Ginsenosides Isolated from Processed Ginseng

Baek

Biological & Pharmaceutical Bulletin

et al. 2011

As part of an ongoing search for immunomodulatory components aimed at the anti-complementary effect, ginsenosides isolated from processed ginseng were found to have inhibitory activity on complement activation through classical pathways. Activity-guided fractionation was used to isolate four ginsenosides, namely ginsenoside Rg 6 , F 4 , Rk 3, and Rh 4 . Ginsenoside Rk 3 and Rh 4 had a 3 fold higher inhibition activity than rosmarinic acid which was used as a positive control while ginsenoside Rg 6 and F 4 showed only mild effects similar to that of the positive control. The results suggest that the activity of the corresponding ginsenosides may be increased by the glycosyl moiety at the C 6 position rather than the double bond conformation at C 20 , and ginsenoside Rk 3 and Rh 4 could have a role in treating inflammatory diseases.

Chemistry & Biodiversity

Naturally Occurring Triterpenoid Saponins

Dinda

Debnath²,

Mohanta

et al. 2010

140

Naturally occurring new triterpenoid saponins reported from mid-1996 to March, 2007 are reviewed including their physical constants and plant sources, and are compiled in Table 1. New saponins are arranged in Table 1 on the basis of the skeletal structures of their aglycones, e.g., oleanane type, ursane type, lupane type, hopane type, taraxastane type, cycloartane type, lanostane type, tirucallane type, dammarane type, cucurbitane type, and holostane type. The known triterpenoid saponins and prosapogenins of the new saponins, the biological and pharmacological activities of which were published during 1996-2007, are also reviewed together with their plant sources listed in Table 2 according to the skeletal structures of their aglycones in the same fashion as in Table 1. The plant and animal sources of both new and known bioactive triterpenoid saponins are collected in Table 3 in alphabetical order. The biological and pharmacological activities such as antiallergic, antiatherosclerosis and antiplatelet, antibacterial, anticomplementary, antidiabetic, contraceptive, antifungal, anti-inflammatory, antileishmanial, antimalarial/antiplasmodial, anti-obesity, anti-proliferative, antipsoriatic, antispasmodic, antisweet, antiviral, cytotoxic/antitumor, detoxication, gastroprotective, haemolytic, hepatoprotective, immunomodulatory, anti-enzyme, anti-osteoporotic, insecticidal, insulin-like, membrane-porosity, molluscicidal, neuropharmacological, anti-endothelial dysfunction, snake venom antidote, and sweet activities of these saponins or derived prosapogenins are discussed briefly after Table 3.