Anticonvulsant action of Calotropis procera latex proteins

Lima, Raquel Cristina De Sousa; Silva, Márcia Calheiros Chaves; Aguiar, Carlos Clayton Torres; Chaves, Edna Maria Camelo; Dias, Kátia Cilene Ferreira; Macêdo, Danielle Silveira; Sousa, Francisca Cléa Florenço de; Carvalho, Krishnamurti de Morais; Ramos, Márcio V.; Vasconcelos, Silvânia Maria Mendes

doi:10.1016/j.yebeh.2011.11.008

Cited by 13 publications

(5 citation statements)

References 28 publications

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“…These chemical contents could be responsible of the traditional use of this plant. Besides, C. procera extracts were reported to possess significant anticonvulsant and analgesic properties [ 42 , 44 ]. Tropanic alkaloids as scopolamin, atropin, hyoscianin isolated in D. innoxia are known for their anticholinergic effects.…”

Section: Discussionmentioning

confidence: 99%

“…They stimulate, inhibit or block liberation, reception or elimination of neurotransmitters [ 147 , 148 ]. Pharmacological results show that the main plants used possess anticonvulsant, anxiolytic, antispasmodic, antinociceptive, analgesic or sedative properties [ 44 , 85 , 111 ]. This result could confirm the presence of psychoactive compounds in these plants.…”

Section: Discussionmentioning

confidence: 99%

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Medicinal Plants Used for Neuropsychiatric Disorders Treatment in the Hauts Bassins Region of Burkina Faso

et al. 2017

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Background: In Burkina Faso, phytotherapy is the main medical alternative used by populations to manage various diseases that affect the nervous system. The aim of the present study was to report medicinal plants with psychoactive properties used to treat neuropsychiatric disorders in the Hauts Bassins region, in the western zone of Burkina Faso. Methods: Through an ethnobotanical survey using structured questionnaire, 53 traditional healers (TH) were interviewed about neuropsychiatric disorders, medicinal plants and medical practices used to treat them. The survey was carried out over a period of three months. Results: The results report 66 plant species used to treat neuropsychiatric pathologies. Roots (36.2%) and leaves (29%) were the main plant parts used. Alone or associated, these parts were used to prepare drugs using mainly the decoction and the trituration methods. Remedies were administered via drink, fumigation and external applications. Conclusions: It appears from this study a real knowledge of neuropsychiatric disorders in the traditional medicine of Hauts Bassins area. The therapeutic remedies suggested in this work are a real interest in the fight against psychiatric and neurological diseases. In the future, identified plants could be used for searching antipsychotic or neuroprotective compounds.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Medicinal Plants Used for Neuropsychiatric Disorders Treatment in the Hauts Bassins Region of Burkina Faso

et al. 2017

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“…[85] Similarly, Calotropis procera latex shows anti-pyretic effects, [86] while root extract showed significant analgesic potential. [87] The leaf extracts of C. gigantea Linn.…”

Section: Analgesic Anticonvulsant Anti-arthritis and Sedative Propementioning

confidence: 99%

Ethnomedicinal, pharmaceutical and pesticidal uses ofCalotropis procera(Aiton) (Family: Asclepiadaceae)

Upadhyay¹

2014

Int J Green Pharm

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Caloropis procera is a multipurpose plant that is extensively used by traditional folk healers and local people for preparation of different drugs and ailments of choice to treat different diseases and disorders. Plant contains diverse phyto-chemicals which show various pharmaceutical and ethno-medicinal properties. Two related species are of Asclepiadaceae, Caloropis procera and Calotropis gigantea, and both possess enormous disease curing potential against various infectious agents such as bacteria, viruses, fungi, protozoans and worms; and are widely used for treatment of different diseases and physiological disorders. Active components of Calotropis procera displayed cytostatic, cytotoxic, wound healing, procogulant, analgesic, anticonvulsant, anti-arthritic, antidiabetic, hepatoprotective, anti-fertility, antipyretic, anti-coccidial, anticancer, antitumor and anti-inflammatory properties. Natural Calotropis latex in preserved and concentrated forms finds many pharmaceutical applications and may be more useful in interventional therapies, complementary and alternative medicine to cure different types of cancers. Latex can be used for preparation of various herbal drugs and drug templates which might be non-steroidal and show wider cancer suppressing efficacy in patients. Plant can become a future source of therapeutic drugs, pesticides and industrial products. It can be used for phyto-extraction of toxic chemicals and reclamation of polluted derelict lands.

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“…Latex proteins of C. procera have been shown to have CNS activity as reflected in their potentiation of pentobarbital-induced sleeping time and their anticonvulsant action in a PTZ-induced seizure model. This demonstrates that C. procera has the ability to cross the blood-brain barrier [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

Neuropharmacological Assessment of the Hydroethanolic Leaf Extract of Calotropis procera (Ait). R. Br. (Apocynaceae) in Mice

et al. 2021

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Background. Calotropis procera has been widely used traditionally for its analgesic and anti-inflammatory effects. It is also reportedly used in ethnomedicine for mental health disorders including epilepsy even in the absence of supporting scientific data. Thus, the potential of the plant to affect neurological functions was evaluated. Methods. Irwin’s test was performed to determine the effect of the oral administration of the extract (30–3000 mg kg−1) on gross behaviour and physiological function. The activity meter, rotarod, pentylenetetrazol- (PTZ-) induced convulsion, pentobarbitone-induced sleep test, and the tail immersion tests were used to evaluate the spontaneous activity, neuromuscular function, convulsive threshold, sedation, and analgesic effects of the Calotropis procera extract (30–1000 mg/kg), respectively, in mice. Results. Calotropis procera extract (CPE) exhibited significant ( p < 0.0001 ) anticonvulsant and analgesic effects. There was a significant increase in withdrawal latency of the CPE-treated animals in the tail immersion test for analgesia ( p < 0.0001 ), while latency and duration of PTZ-induced convulsions were positively modulated. Calotropis procera extract showed significant ( p < 0.0001 ) central nervous system depressant effects in pentobarbitone-induced hypnosis at 100–1000 mg/kg and spontaneous activity test (30–1000 mg/kg). The extract also depicted impaired motor coordination at 100–1000 mg/kg dose levels. LD50 was estimated to be above 1000 mg kg−1. Conclusions. Calotropis procera extract has significant central nervous system depressant and analgesic effects in mice.

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Anticonvulsant action of Calotropis procera latex proteins

Cited by 13 publications

References 28 publications

Medicinal Plants Used for Neuropsychiatric Disorders Treatment in the Hauts Bassins Region of Burkina Faso

Medicinal Plants Used for Neuropsychiatric Disorders Treatment in the Hauts Bassins Region of Burkina Faso

Ethnomedicinal, pharmaceutical and pesticidal uses ofCalotropis procera(Aiton) (Family: Asclepiadaceae)

Neuropharmacological Assessment of the Hydroethanolic Leaf Extract of Calotropis procera (Ait). R. Br. (Apocynaceae) in Mice

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