Anticonvulsant Activity of Majoon Najah Against PTZ Induced Seizure in Swiss Albino Mice

Afrin, Zeba; Siddiqui, Aisha; Jafri, MA; Vohora, Divya; Asif, Mohammad

doi:10.26438/ijsrbs/v5i6.170179

Cited by 2 publications

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“…14 In the present study we have tested the anticonvulsant and antidepressant activity in rodents. Data of antiepileptic study showed that in spite of reduction of THLE, clonic convulsion and stupor phase in rats, the values obtained were not found significantly different at any tested dose level for classical MN or MN extract 15 reported significant reduction in THLE and seizure threshold in Increased Current Electroshock Seizure (ICES) method in Swiss albino mice at 1700 mg/kg bw of MN and 260 mg/kg bw of hydro ethanolic extract (ethanol and distilled water ratio 80:20) of MN following one week treatment. The observed difference in activity in our study may be attributable to variables like species difference (SD rats versus Swiss albino mice) and methodology adopted (MES at 150 mAmp in our study versus ICES upto 30mAmp current).In PTZ model, although mortality was reduced in all treated mice compared to vehicle treatment group, the seizures score in MN treated group animals was not statistically different as compared to control (though score was reduced).…”

Section: Discussionmentioning

confidence: 81%

“…Findings of our study are contrary to the reported antiepileptic effect of MN in mice. 15 The antidepressant activity of MN was evaluated using FST model in rats. The results indicated that MN effectively showed significant (P<0.001) reduction in immobility duration in animals treated with MN classical at dose 500 mg/kg bw and 1000 mg/kg bw as compared to control rats.…”

Section: Discussionmentioning

confidence: 99%

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Antiepileptic and Antidepressant Activity of Majoon Najah (A Traditional Unani Formulation) in Experimental Animals

Urooj

Husain

Nadeem

et al. 2020

IJPI

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Background: Majoon Najah is a polyherbal traditional Unani formulation recommended for the treatment of neurological disorders. To evaluate antiepileptic and antidepressant activity of majoon najah and majoon najah extract in experimental animals. Methods: Anticonvulsant activity was tested using maximal electroshock induced convulsion in male sprague dawley rats using diazepam 3 mg/kg, p.o. as positive control. Pentylenetetrazole induced convulsion in swiss male albino mice was performed using phenytoin 25 mg/kg i.p. as positive control. The antidepressant activity of MN was evaluated using forced swim test model in male using Imipramine 20 mg/kg, p.o. as positive control. Results: Antiepileptic study data showed reduction of all parameters like, tonic hind limb extension, clonic convulsion and stupor; however the values were not found statistically significant at all tested dose levels. The results of forced swim test model indicated that majoon najah effectively showed significant (P<0.001) reduction in immobility duration in animals treated with majoon najah classical at dose 500 mg/kg bw and 1000 mg/kg bw as compared to control rats. Conclusion: Based on above findings, it may be concluded that majoon najah did not showed effectiveness in epilepsy however, the results evident that majoon najah is a potential Unani formulation having antidepressant activity which may be preferred as an alternative therapy over modern medicine to treat depression.

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Section: Discussionmentioning

confidence: 81%

Section: Discussionmentioning

confidence: 99%

Antiepileptic and Antidepressant Activity of Majoon Najah (A Traditional Unani Formulation) in Experimental Animals

Urooj

Husain

Nadeem

et al. 2020

IJPI

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Evaluation of Hepatoprotective Efficacy of a Polyherbal Unani Formulation Majoon-Najah against Cadmium Chloride-induced Liver Damage

Singh

Gupta

Bharti

et al. 2023

CDRR

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Background: Majoon-Najah is a composite Unani formulation that consists of multiple medicinal plants and is advised for neurological illnesses. Several studies were carried out on Majoon-Najah (MN) and its ingredients to evaluate the protective effect against seizure and antidepressant activity in animals using a classical form as well as extract. Terminalia bellerica and Emblica officinalis are the major constituents of MN. Scientifically documented literature summarises the hepatoprotective potential of these constituents. Aim: The current study aimed to evaluate the possible hepatoprotective, antioxidant and anti-inflammatory perspective of traditional Indian Unani formulation MN and Majoon-Najah hydro-alcoholic extract (MNHE) in a Guinea pig model. Methods: Thirty adult male albino guinea pigs were randomly assigned into five groups for this study. MN and MNHE were given intragastrically for 15 days, followed by intraperitoneal Cadmium chloride (CdCl2, 3 mg/kg/day) from days 8 to 15, as per the schedule. Blood samples were taken from the heart on the 16th day, and the liver was operated on for biochemical analysis and histopathology under complete anesthesia. Results: CdCl2 changed the levels of liver function markers, serum biochemical indicators like albumin, total protein, glucose, and cholesterol in the blood; lipid peroxidation (MDA), glutathione reductase (GSH), superoxide dismutase (SOD), and glutathione peroxidase (GPX) in hepatic tissue homogenate, pro-inflammatory cytokines level and liver cytoarchitecture. MN and MNHE were found to protect guinea pigs’ liver from CdCl2-induced injury by lowering raised parameters and increasing enzymatic antioxidants. MN and MNHE did not significantly heal injured liver tissues caused by CdCl2 in histopathological examinations. Conclusion: CdCl2 induces hepatotoxicity that is likely to worsen with increasing dosage and duration of exposure. MN and MNHE exert their hepatoprotective action by scavenging free radicals, decreasing malondialdehyde levels, activating antioxidant enzymes, and down-regulating proinflammatory indicators.

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Anticonvulsant Activity of Majoon Najah Against PTZ Induced Seizure in Swiss Albino Mice

Cited by 2 publications

References 0 publications

Antiepileptic and Antidepressant Activity of Majoon Najah (A Traditional Unani Formulation) in Experimental Animals

Antiepileptic and Antidepressant Activity of Majoon Najah (A Traditional Unani Formulation) in Experimental Animals

Evaluation of Hepatoprotective Efficacy of a Polyherbal Unani Formulation Majoon-Najah against Cadmium Chloride-induced Liver Damage

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