Anticonvulsant activity of Pseudospondias microcarpa (A. Rich) Engl. hydroethanolic leaf extract in mice: The role of excitatory/inhibitory neurotransmission and nitric oxide pathway

Adongo, Donatus Wewura; Mante, Priscilla Kolibea; Kukuia, Kennedy Kwami Edem; Biney, Robert Peter; Boakye‐Gyasi, Eric; Benneh, Charles Kwaku; Ameyaw, Elvis Ofori; Woode, Eric

doi:10.1016/j.jep.2017.05.017

Cited by 14 publications

(14 citation statements)

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“…In recent times, quite a number of Ghanaian plants have been shown to exhibit diverse central nervous system activities ranging from anxiolytic activity to antidepressant and anticonvulsant activity [ 11 , 17 – 19 ]. Prior to the working with the petroleum ether/ethyl acetate fraction of the stem bark (Maerua angolensis) , FT-IR spectra were generated.…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…Evidence gathered over the past decade suggests the involvement of nitric oxide (NO) in the onset, intensity, and progression of seizures, including PTZ-induced seizures [ 19 , 26 , 27 ]. Although some conflicting data exist, most works suggest that decreased nitric oxide production leads to anticonvulsant effects, while increased NO levels produce proconvulsant effects in PTZ-induced seizures [ 2 , 19 , 27 ]. These effects were further corroborated by works done by Akula and colleagues [ 28 ], where the authors observed potentiating effects of anticonvulsant activity of subeffective doses of adenosine after pretreatment with l -NAME (a nonselective nitric oxide synthase inhibitor) and a reversal of effect after pretreatment with L-arginine (a precursor of nitric oxide) or sildenafil (a phosphodiesterase V enzyme inhibitor).…”

Section: Discussionmentioning

confidence: 99%

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Maerua angolensis DC. (Capparaceae) Stem Bark Extract Protects against Pentylenetetrazole‐Induced Oxidative Stress and Seizures in Rats

Benneh

Biney

Tandoh

et al. 2018

Evidence-Based Complementary and Alternative Medicine

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Introduction The stem bark of Maerua angolensis DC. (Capparaceae) is traditionally used for management of epilepsy. Our aim was to evaluate the antiseizure potential and identify possible mechanisms by which the effects are registered. Methods The petroleum ether/ethyl acetate extract (100–1000 mg kg−1) was administered per os to male Sprague-Dawley rats after pretreatment with flumazenil (0.3 mg kg−1) or L-arginine (150 mg kg−1) or sildenafil (5 mg kg−1) and they subsequently received a subcutaneous injection of pentylenetetrazole (65 mg kg−1). Rats were observed for latency to and duration of myoclonic seizures and additionally the level of protection against oxidant markers and products was assessed in vitro and in vivo. Results The extract (300 and 1000 mg kg−1, p.o.) significantly delayed the onset and decreased the duration and frequency of PTZ-induced convulsions. The anticonvulsant effect of MAE (300 mg kg−1, p.o.) was reversed by pretreatment with flumazenil, L-arginine, or sildenafil. Also, MAE (300 mg kg−1) treatment reversed significantly PTZ-induced oxidative stress in rat brain tissue. Conclusion The petroleum ether/ethyl acetate fraction exhibits antiseizure activity by affecting GABAergic and nitric oxide-cGMP pathways. In addition, the extract protects against the generation of free radicals and the oxidative products of the PTZ-induced seizures.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Maerua angolensis DC. (Capparaceae) Stem Bark Extract Protects against Pentylenetetrazole‐Induced Oxidative Stress and Seizures in Rats

Benneh

Biney

Tandoh

et al. 2018

Evidence-Based Complementary and Alternative Medicine

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“…[55,56] Different plant extracts were reported to possess CNS-depressant activity with interesting safety profile. [57][58][59][60] According to the literature, S. foetida at 50, 100 and 200 mg/kg exhibited a potent antidepressant activity. The results showed that pentobarbitone sleeping time was significantly potentiated in normal and chronically treated mice upon pretreatment with the ethanolic extract of S. foetida leaves in addition to significant potentiation in barbital sodium sleeping time comparable to chlorpromazine HCl.…”

Section: Anticonvulsant and Cns-depressant Activitymentioning

confidence: 99%

Sterculia and Brachychiton: a comprehensive overview on their ethnopharmacology, biological activities, phytochemistry and the role of their gummy exudates in drug delivery

Thabet

Youssef

El-Shazly

et al. 2018

Journal of Pharmacy and Pharmacology

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Objectives Sterculia and Brachychiton are two related genera (Malvaceae) containing more than 300 species. Most of these species are ornamental trees that are native to Australia and widely cultivated in many countries. Different members of the two genera were used by various cultures for medicinal and economical purposes. This review sheds light on the medicinal values and chemical composition of various species of these two genera. Key findings Sterculia and Brachychiton species were used traditionally for the treatment of gastrointestinal disorders, microbial infection, skin diseases, inflammation and many other conditions. The seeds of various species were roasted and eaten by many traditional tribes. Plants from the two genera revealed their anti-inflammatory, antioxidant, antimicrobial, antidiabetic, antiulcer, insecticidal and analgesic activity. These activities may be attributed to the presence of a wide range of secondary metabolites as flavonoids, phenolic acids, coumarins, terpenoids particularly sesquiterpenes and triterpenes in addition to sterols and fatty acids. Moreover, the gummy exudates obtained from some members of these genera played an important role in different pharmaceutical dosage forms and drug-delivery systems. Conclusions More research is recommended on other species of Sterculia and Brachychiton to discover new molecular entities with potential biological and economic values.

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“…Pseudospondias microcarpa is one of such plants used for treating various diseases including central nervous system (CNS) disorders, arthritis, rheumatism, eye problems, kidney disorders, nasopharyngeal infections, stomach complaints, malaria, and jaundice [ 4 ]. Various studies have also shown the plant to possess antioxidant [ 5 ], antimicrobial [ 6 ], anticonvulsant [ 7 ], antidepressant [ 8 , 9 ], anxiolytic [ 10 ], sedative, analgesic [ 11 ] and cytotoxic and antiplasmodial effects [ 12 ]. As demonstrated by Yondo et al [ 5 ], we have shown in a previous study that the leaves of the plant contain some phytochemical constituents which may be responsible for its biologic activity [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

Toxicological Assessment of Pseudospondias microcarpa (A. Rich.) Engl. Hydroethanolic Leaf Extract in Rats: Haematological, Biochemical, and Histopathological Studies

Adongo

Mante

Kukuia

et al. 2018

The Scientific World Journal

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Pseudospondias microcarpa is used traditionally for treating various diseases. However, although parts of the plant are extensively used in African traditional medicine, no scientific study has been reported on its toxicity. Therefore, this study evaluated the acute and subacute toxicity studies of the ethanolic extract of P. microcarpa in rats. Male Sprague-Dawley rats (120–150 g) were treated orally with the extract (30, 100, 300, 1000, and 3000 mg kg−1) or distilled water (10 ml kg−1) for 2 weeks and observed daily for general appearance and signs of toxicity. In addition, blood was collected for both biochemical and haematological assays. Sections of tissues from liver, kidney, spleen, brain, and stomach were also used for histopathological examination. Administration of the extract for 14 consecutive days caused no deaths, with an LD50 above 3000 mg kg−1. Except for lymphocytes (%) that showed a significant decrease (F5,23 = 3.93, P = 0.013), all other haematological parameters remained unaffected by the extract. The extract at 100 mg kg−1 showed a significant decrease in the levels of triglyceride and very-low-density lipoproteins (both at P < 0.05). Weight change as well as histological evaluation of the organs indicated no toxicity. The study demonstrates that an ethanolic extract of P. microcarpa given orally to rats is safe.

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Anticonvulsant activity of Pseudospondias microcarpa (A. Rich) Engl. hydroethanolic leaf extract in mice: The role of excitatory/inhibitory neurotransmission and nitric oxide pathway

Cited by 14 publications

References 58 publications

Maerua angolensis DC. (Capparaceae) Stem Bark Extract Protects against Pentylenetetrazole‐Induced Oxidative Stress and Seizures in Rats

Maerua angolensis DC. (Capparaceae) Stem Bark Extract Protects against Pentylenetetrazole‐Induced Oxidative Stress and Seizures in Rats

Sterculia and Brachychiton: a comprehensive overview on their ethnopharmacology, biological activities, phytochemistry and the role of their gummy exudates in drug delivery

Toxicological Assessment of Pseudospondias microcarpa (A. Rich.) Engl. Hydroethanolic Leaf Extract in Rats: Haematological, Biochemical, and Histopathological Studies

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