Antidepressant-like activity of Tagetes lucida Cav. is mediated by 5-HT1A and 5-HT2A receptors

Bonilla-Jaime, Herlinda; Guadarrama-Cruz, G.; Alarcón-Aguilar, Francisco Javier; Limón-Morales, Ofelia; Vázquez-Palacios, Gonzalo

doi:10.1007/s11418-015-0909-5

Cited by 35 publications

(26 citation statements)

References 44 publications

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“…Naringenin also revealed an antidepressant property by elevation of serotonin and norepinephrine concentration [ 34 ]. Recent studies demonstrated that quercetin, an extract of Tagetes lucida which has the similar structure with myricetin, may modulate the release and re-uptake of serotonin [ 35 ]. Another study also reported that myricetin may directly inhibit the activity of serotonin N -acetyltransferase, which catalyzes the conversion of serotonin to N -acetylserotonin [ 36 ].…”

Section: Discussionmentioning

confidence: 99%

Myricetin Attenuates Depressant-Like Behavior in Mice Subjected to Repeated Restraint Stress

Wang

Cui

et al. 2015

IJMS

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Increasing evidence has shown that oxidative stress may be implicated in chronic stress-induced depression. Several flavonoids with anti-oxidative effects have been proved to be anti-depressive. Myricetin is a well-defined flavonoid with the anti-oxidative, anti-inflammatory, anti-apoptotic, and neuroprotective properties. The aim of the present study is to investigate the possible effects of chronic administration of myricetin on depressant-like behaviors in mice subjected to repeated restraint (4 h/day) for 21 days. Our results showed that myricetin administration specifically reduced the immobility time in mice exposed to chronic stress, as tested in both forced swimming test and tail suspension test. Myricetin treatment improved activities of glutathione peroxidase (GSH-PX) in the hippocampus of stressed mice. In addition, myricetin treatment decreased plasma corticosterone levels of those mice subjected to repeated restraint stress. The effects of myricetin on the brain-derived neurotrophic factor (BDNF) levels in hippocampus were also investigated. The results revealed that myricetin normalized the decreased BDNF levels in mice subjected to repeated restraint stress. These findings provided more evidence that chronic administration of myricetin improves helpless behaviors. The protective effects of myricetin might be partially mediated by an influence on BDNF levels and might be attributed to myricetin-mediated anti-oxidative stress in the hippocampus.

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Section: Discussionmentioning

confidence: 99%

Myricetin Attenuates Depressant-Like Behavior in Mice Subjected to Repeated Restraint Stress

Wang

Cui

et al. 2015

IJMS

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“…[ 13 14 15 16 ] TL Cav., which is known in Mexico as pericón, is used as an ornamental plant and has antifungal, antibacterial, larvicidal, and antidepressant activities. [ 17 18 ]…”

Section: Discussionmentioning

confidence: 99%

Anti-inflammatory effect of aqueous extracts of spent Pleurotus ostreatus substrates in mouse ears treated with 12-O-tetradecanoylphorbol-13-acetate

et al. 2016

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Aims:To evaluate the application of spent Pleurotus ostreatus substrates, enriched or not with medicinal herbs, as a source of anti-inflammatory compounds.Subjects and Methods:P. ostreatus was cultivated on five different substrates: Barley straw (BS) and BS combined 80:20 with medicinal herbs (Chenopodium ambrosioides L. [BS/CA], Rosmarinus officinalis L. [BS/RO], Litsea glaucescens Kunth [BS/LG], and Tagetes lucida Cav. [BS/TL]). The anti-inflammatory activity of aqueous extracts of spent mushroom substrates (SMSs) (4 mg/ear) was studied using an acute inflammation model in the mouse ear induced with 2.5 μg/ear 12-O-tetradecanoylphorbol13-acetate (TPA).Results:Groups treated with BS/CA, BS/RO, and BS/LG aqueous extracts exhibited the best anti-inflammatory activity (94.0% ± 5.5%, 92.9% ± 0.6%, and 90.4% ± 5.0% inhibition of auricular edema [IAO], respectively), and these effects were significantly different (P < 0.05) from that of the positive control indomethacin (0.5 mg/ear). BS/TL and BS were also able to reduce TPA-induced inflammation but to a lesser extent (70.0% ± 6.7% and 43.5% ± 6.6% IAO, respectively).Conclusions:Spent P. ostreatus substrate of BS possesses a slight anti-inflammatory effect. The addition of CA L. to mushroom substrate showed a slightly synergistic effect while RO L. had an additive effect. In addition, LG Kunth and TL Cav. enhanced the anti-inflammatory effect of SMS. However, to determine whether there is a synergistic or additive effect, it is necessary to determine the anti-inflammatory effect of each medicinal herb.

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“…Antiinflammatory: induced nitric oxide and prostaglandin E2 production as well as the expression of COX-2 in macrophages was significantly inhibited by the essential oil (0.05-0.2 mg/ml) (Sepuĺveda-Arias et al, 2013). Antidepressant and anxiolytic: aqueous and organic extracts (10-300 mg/kg IP or 5-200 mg/kg PO for 14 days) showed significant effects in various rodent models; the antidepressantlike effects were shown to be mediated via a serotonergic mechanism (Guadarrama- Cruz et al, 2008;Gabriela et al, 2012;Guadarrama-Cruz et al, 2012;Bonilla-Jaime et al, 2015;Peŕez-Ortega et al, 2016).…”

Section: Likely Effective and Possibly Safe D9mentioning

confidence: 99%

Traditional Herbal Medicine in Mesoamerica: Toward Its Evidence Base for Improving Universal Health Coverage

et al. 2020

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The quality of health care in Mesoamerica is influenced by its rich cultural diversity and characterized by social inequalities. Especially indigenous and rural communities confront diverse barriers to accessing formal health services, leading to often conflicting plurimedical systems. Fostering integrative medicine is a fundamental pillar for achieving universal health coverage (UHC) for marginalized populations. Recent developments toward health sovereignty in the region are concerned with assessing the role of traditional medicines, and particularly herbal medicines, to foster accessible and culturally pertinent healthcare provision models. In Mesoamerica, as in most regions of the world, a wealth of information on traditional and complementary medicine has been recorded. Yet these data are often scattered, making it difficult for policy makers to regulate and integrate traditionally used botanical products into primary health care. This critical review is based on a quantitative analysis of 28 survey papers focusing on the traditional use of botanical drugs in Mesoamerica used for the compilation of the "Mesoamerican Medicinal Plant Database" (MAMPDB), which includes a total of 12,537 use-records for 2188 plant taxa. Our approach presents a fundamental step toward UHC by presenting a pharmacological and toxicological review of the cross-culturally salient plant taxa and associated botanical drugs used in traditional medicine in Mesoamerica. Especially for native herbal drugs, data about safety and effectiveness are limited. Commonly used cross-culturally salient botanical drugs, which are considered safe but for which data on effectiveness is lacking constitute ideal candidates for treatment outcome studies.

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Antidepressant-like activity of Tagetes lucida Cav. is mediated by 5-HT1A and 5-HT2A receptors

Cited by 35 publications

References 44 publications

Myricetin Attenuates Depressant-Like Behavior in Mice Subjected to Repeated Restraint Stress

Myricetin Attenuates Depressant-Like Behavior in Mice Subjected to Repeated Restraint Stress

Anti-inflammatory effect of aqueous extracts of spent Pleurotus ostreatus substrates in mouse ears treated with 12-O-tetradecanoylphorbol-13-acetate

Traditional Herbal Medicine in Mesoamerica: Toward Its Evidence Base for Improving Universal Health Coverage

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