Antidepressant-like effect of lamotrigine in the mouse forced swimming test: Evidence for the involvement of the noradrenergic system

Kaster, Manuella P.; Raupp, Inara; Binfaré, Ricardo W.; Andreatini, Roberto; Rodrigues, Ana Lúcia S.

doi:10.1016/j.ejphar.2007.03.003

Cited by 67 publications

(44 citation statements)

References 38 publications

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“…These results suggest that the effect of HEA in the TST is dependent on the availability of noradrenaline and/or dopamine in the nerve terminal. The effect of AMPT in preventing the antiimmobility activity of antidepressants is well reported in the literature (Cunha et al, 2013;Kaster et al, 2007). Moreover, these effects have also been shown in clinical experiments (Bremner et al, 2003;Delgado et al, 2002).…”

Section: Discussionmentioning

confidence: 56%

Involvement of the catecholaminergic system on the antidepressant-like effects ofAlpinia zerumbetin mice

Bevilaqua

Mocelin

Grimm

et al. 2015

Pharmaceutical Biology

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Section: Discussionmentioning

confidence: 56%

Involvement of the catecholaminergic system on the antidepressant-like effects ofAlpinia zerumbetin mice

Bevilaqua

Mocelin

Grimm

et al. 2015

Pharmaceutical Biology

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“…Effective and sub-effective doses of lamotrigine was determined by its injection in different doses of 5, 10, and 30 mg/kg 30 min before the behavioral experiments. These doses and times of administration were chosen based on previous study [44]. Fluoxetine (20 mg/kg), a selective serotonin reuptake inhibitor, was injected as a standard antidepressant drug.…”

Section: Treatmentsmentioning

confidence: 99%

Pharmacological evidence for the involvement of the NMDA receptor and nitric oxide pathway in the antidepressant-like effect of lamotrigine in the mouse forced swimming test

Ostadhadi

Ahangari

Nikoui

et al. 2016

Biomedicine & Pharmacotherapy

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“…Both epidemiological and animal studies have shown obesity to be a risk factor for mood disorders including depression. [24][25][26][27][28][29][30][31][32][33][34][35][36][37][38][39] Diabetic rats have also been shown to develop signs of depression. 40,41 However, how obesity or diabetes may lead to depression is not very well characterized.…”

Section: Discussionmentioning

confidence: 99%

Effect of Metabolic Syndrome on Depression in Mice

Mukherjee¹,

Sen²,

Banerjee³

2017

IJPER

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Metabolic syndrome (MetS) is associated with high blood glucose, insulin resistance, dyslipidemia, central obesity, and hypertension. There is clinical evidence of the coexistence of depression and MetS, however, pathways associating these diseases are far from clear. In the present study, we evaluate and determine the pathogenesis of depression in MetS animals. Methods: Diet induced (High-fat diet long with 20% fructose water; HFHC diet for 4 weeks) MetS was developed in swiss albino mice. Fasting blood glucose levels, Lipids and blood pressure (BP) was measured in these animals. Development of depression in these animals was determined using forced swim and tail suspension tests. This was followed by measurement of GABA, dopamine, serotonin and norepinephrine levels in these animals. We also evaluated the effect of various antidepressants, on MetS associated depression. Results: MetS was induced using high fat and high carbohydrate (HFHC) diet in Swiss albino mice with high fasting blood glucose levels (>250 mg/dl), significantly increased LDL (p<0.001) and triglyceride (p<0.01) and reduced HDL levels (p<0.05) and significant increase in systolic BP; p<0.001) compared to normal controls. MetS animals showed signs of depression with significantly higher (p<0.001) immobility time in forced swim and tail suspension tests. These animals showed significantly lower corticohippocampal norepinephrine (NE) levels (p<0.01) compared to controls. Nortryptaline, showed a dose dependent decrease in immobility time in MetS animals (p<0.001) in both forced swim and tail suspension tests thus reversing MetS induced depression. Conclusion: The above results suggest that MetS may lead to depression in mice which is primarily mediated by NE system.

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Antidepressant-like effect of lamotrigine in the mouse forced swimming test: Evidence for the involvement of the noradrenergic system

Cited by 67 publications

References 38 publications

Involvement of the catecholaminergic system on the antidepressant-like effects ofAlpinia zerumbetin mice

Involvement of the catecholaminergic system on the antidepressant-like effects ofAlpinia zerumbetin mice

Pharmacological evidence for the involvement of the NMDA receptor and nitric oxide pathway in the antidepressant-like effect of lamotrigine in the mouse forced swimming test

Effect of Metabolic Syndrome on Depression in Mice

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